Simultaneous determination of Dopamine, Uric acid and Folic acid with Electrochemical Techniques based on Co3O4/rGO/CTAB Modified Carbon Paste Electrode

Abstract

The electrochemical has been constructed based on Co 3 O 4 /rGO nanocomposite in presence of CTAB modified carbon paste electrode (CPE) and was developed for the simultaneous determination of dopamine, uric acid and folic acid at physiological pH 7.0 (PBS, 0.1 M). The physico-chemical analysis of nanocomposite was characterized by FT-IT, PXRD, SEM, TEM and EDX. The modified sensor showed well defined and stable reversible peak couple in both alkaline and aqueous solution. From the differential pulse voltammetry (DPV), the electrochemical sensor showed excellent electrocatalytic activity for the oxidation of dopamine, limit of detection (LOD) and limit of quantification (LOQ) of DA are calculated to be 2.8 µM and 10 µM, respectively. The Co 3 O 4 /rGO/CTAB MCPE showed an efficient electron mediating behavior with well defined oxidation peak potentials between DA to UA and UA to FA were 0.12 V and 0.39 V, respectively. From the cyclic voltammetry the results obtained for the linear calibration plots and the limit of detection of DA, UA and FA were calculated to be 7 µM, 94 µM and 19 µM, respectively. The developed sensor was successfully employed to sensing of DA in real samples.

Silky Co3O4 nanostructures for the selective and sensitive enzyme free sensing of uric acid

“… 38 Moreover, Co 3 O 4 is composed of mixed Co 2+ and Co 3+ ions located on tetrahedral and octahedral site respectively which play a significant role in the electrochemical activity of Co 3 O 4 . 39 Furtherer more, Co 3 O 4 material has been hybridized with different materials such as graphene, graphene oxide, quantum dots, carbon nanotube to improve the electron transfer tendency of Co 3 O 4 modified electrode. 40–42 Also, Co 3 O 4 -based nanocomposites have been reported in the literature for the electrochemical determination of UA.…”

“… 40–42 Also, Co 3 O 4 -based nanocomposites have been reported in the literature for the electrochemical determination of UA. 39,43 Despite the superior performance of composite materials, however they involve complicated steps during their synthesis and require highly sensitive analytical techniques to characterize them. Therefore, both high cost during the synthesis and characterization again allow the researchers to think and design new pristine materials with outperform functionalities.…”

“…Among them, cobalt oxide (Co 3 O 4 ) is best choice because of its special properties such as low cost, non-toxic, and excellent chemical durability etc 38. Moreover, Co 3 O 4 is composed of mixed Co 2+ and Co 3+ ions located on tetrahedral and octahedral site respectively which play a signicant role in the electrochemical activity of Co 3 O 4 39.…”

Sensitive and Stable Electrochemical Sensor for Folic Acid Determination Using a ZIF-67/AgNWs Nanocomposite

“…For example, Venu et al synthesized Co 3 O 4 /reduced graphene oxide (rGO) nanocomposites for the construction of electrochemical sensors for the determination of FA, which exhibited effective electron-mediated behavior with a determination limit of 19 μM. However, the material was synthesized under high pressure and high temperature [ 27 ]. Abdelwahab et al synthesized gold nanoclusters (AuNCs)/activated graphene (AGR)/MWCNT nanocomposite, which could be obtained by electrochemical reduction with an enhanced current response to FA oxidation with a determination limit as low as 0.09 μM.…”

Highly Sensitive Electrochemical Detection of Folic Acid by Using a Hollow Carbon Nanospheres@molybdenum Disulfide Modified Electrode

“…As an indispensable nutrient for the body functions, folic acid (FA), called also vitamin B9, is very vital in the periods of rapid cell growth and division, 1,2 and it is also crucial to produce red blood cell, improve brain health and hearing loss, synthesize and repair DNA/RNA. The lack of FA can arouse various numerous diseases such as megaloblastic anemia, cancer, metabolic syndromes, Finally, the prepared CHN@MoS2 were annealed in N2 atmosphere at high temperature.…”