Highly Sensitive Electrochemical Detection of Folic Acid by Using a Hollow Carbon Nanospheres@molybdenum Disulfide Modified Electrode

Abstract

As a nutrient in body functions, folic acid (FA) plays a very important role for human health, thus developing highly sensitive method for its determination is of great significance. In the present work, hollow carbon nanospheres decorated with molybdenum disulfide nanosheets (CHN@MoS2) nanomaterials were produced through a simple method and adopted to modify glassy carbon electrode for assembling a highly sensitive electrochemical sensor of FA. After characterizing the prepared nanomaterials using scanning-/transmission-electron microscopy and Raman spectra as well as optimizing various testing conditions including pH value of buffer solution, accumulation time and amount of nanomaterials on electrode surface, the electrochemical determination of FA was carried out using CHN@MoS2 electrode. Owing to the coordinative advantages from CHN and MoS2, the results show that CHN@MoS2 exhibits excellent sensing responses for FA, and it has wide linear range from 0.08 to 11.0 μM coupled with a low detection limit of 0.02 μM. Finally, the proposed method for FA detection was applied successfully in human serum analysis and the obtained results are satisfactory, revealing the developed method based on CHN@MoS2 nanomaterials has important applications for FA determination.

Electrochemical Cytosensor Based on a Gold Nanostar-Decorated Graphene Oxide Platform for Gastric Cancer Cell Detection

“…FA is a water-soluble vitamin essential for cellular division and prenatal development [ 31 , 32 , 33 ]. It can bind to folate receptors (FRs) with a high affinity and then enter the cell by FR-mediated endocytosis [ 34 ].…”

Highly sensitive determination of anesthetic drug benzocaine based on hydroxypropyl-β-cyclodextrin–carbon black nanohybrids

“…On the other hand, various carbon-based materials (particularly carbon nanotubes and graphene) have received a great deal of attention in the past decades in electroanalysis owing to their large specic surface area, excellent conductivity and high chemical stability. [15][16][17][18][19] Nevertheless, their preparation procedures are very tough. Another carbonaceous material consisting of amorphous/quasi-graphitic primary particles, carbon black (CB), has gained increasing attention and emphasis by researchers recently, 20,21 and it boasts numerous interesting chemical/physical superiorities, such as large supercial area, excellent conductivity and chemical stability.…”