Simultaneous determination of cytosine arabinoside, daunorubicin and etoposide in human plasma

Krogh-Madsen, Mikkel; Hansen, Steen Honoré; Honoré, Per Hartvig

doi:10.1016/j.jchromb.2010.05.031

Cited by 26 publications

(19 citation statements)

References 27 publications

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“…From the 35 publications included in this overview, 12 quantify only one main compound [26,[42][43][44][45][46][47][48][49][50][51][52]. Others determine a main compound and its reduced metabolite [27,[53][54][55][56][57][58][59], sometimes together with additional 8 metabolites [24,[60][61][62][63][64][65][66][67].…”

Section: Analytes and Concentrations Of Interestmentioning

confidence: 99%

“…Besides silica based reversedphase C18 [46,47,56,60,66,67,70], C8 [72] and C2 [44,65] sorbents, also polymeric Oasis HLB [48,49,57,71] and MCX [50] sorbents have been employed. A Biotrap 500 MS online SPE column has also been used [69].…”

Section: Solid Phase Extractionmentioning

confidence: 99%

“…To avoid losses due to protein binding, samples have sometimes been diluted [50,65,66,71,72] or have been subjected to a protein precipitation step [57] prior to loading on the sorbent.…”

Section: Solid Phase Extractionmentioning

confidence: 99%

“…Mild washing conditions, usually consisting of water, a neutral or slightly acidic buffer, sometimes in the presence of a small percentage of organic solvent (up to 10% methanol or acetonitrile), have been applied [44,[46][47][48][49][50]56,57,60,65,67,[69][70][71][72]. Occasionally, a stronger (additional) wash-step was included: 25 or 30% methanol at neutral pH [50,56,66], 40% methanol at alkaline conditions [48,49] or hexane [46].…”

Section: Solid Phase Extractionmentioning

confidence: 99%

“…Occasionally, a stronger (additional) wash-step was included: 25 or 30% methanol at neutral pH [50,56,66], 40% methanol at alkaline conditions [48,49] or hexane [46]. Mild washing conditions improve recoveries, especially if the reduced metabolites or glucuronic acid conjugates have to be included in the assay.…”

Section: Solid Phase Extractionmentioning

confidence: 99%

See 4 more Smart Citations

Quantitative liquid chromatographic analysis of anthracyclines in biological fluids

Maudens

Stove

Lambert

2011

Journal of Chromatography B

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Section: Analytes and Concentrations Of Interestmentioning

confidence: 99%

Section: Solid Phase Extractionmentioning

confidence: 99%

“…To avoid losses due to protein binding, samples have sometimes been diluted [50,65,66,71,72] or have been subjected to a protein precipitation step [57] prior to loading on the sorbent.…”

Section: Solid Phase Extractionmentioning

confidence: 99%

Section: Solid Phase Extractionmentioning

confidence: 99%

Section: Solid Phase Extractionmentioning

confidence: 99%

See 3 more Smart Citations

Quantitative liquid chromatographic analysis of anthracyclines in biological fluids

Maudens

Stove

Lambert

2011

Journal of Chromatography B

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Simultaneous determination of cytosine arabinoside and its metabolite, uracil arabinoside, in human plasma using hydrophilic interaction liquid chromatography with UV detection

Uchiyama

Takamatsu

Ogata

et al. 2013

Biomedical Chromatography

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A practical high-performance liquid chromatography using a Cosmosil HILIC column and UV detection was developed for determining the concentrations of cytosine arabinoside (Ara-C) and uracil arabinoside (Ara-U), which is a major metabolite of Ara-C, in human plasma. This method was used to determine the plasma concentrations of Ara-C and Ara-U in a patient treated with high-dose Ara-C therapy for end-stage renal failure.

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HPLC‐UV method for quantifying etoposide in plasma and tumor interstitial fluid by microdialysis: application to pharmacokinetic studies

Pigatto

Mossmann

Costa

2014

Biomedical Chromatography

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A simple and sensitive bioanalytical method was developed and validated for determination of etoposide in plasma and microdialysis samples of Walker-256 tumor-bearing rats. A microdialysis probe was implanted in the center of a subcutaneous tumor and Ringer's solution was used as perfusion medium. Chromatographic separation was conducted on a Shimadzu CLC-C8 column using a mobile phase consisting of water-acetonitrile (70:30; v/v) adjusted to pH 4.0 ± 0.1 with formic acid at a gradient flow rate of 1.0-0.6 mL/min, an injection volume of 30 μL and UV detection at 210 nm. Microdialysate samples were analyzed without processing and plasma samples (100 μL) were spiked with phenytoin as internal standard (IS) (1 µg/mL) followed by extraction with tert-butyl methyl ether. The organic layer was evaporated and reconstituted with 100 μL of mobile phase before injection. The methods for plasma and microdialysate were linear in the ranges of 25-10,000 ng/mL and of 10-1500 ng/mL, respectively. All the validation parameters such as intra- and inter-day precision and accuracy and stability were within the limits established by international guidelines. The present method was successfully applied in the investigation of etoposide pharmacokinetics in rat plasma and microdialysate tumor samples following a single 15 mg/kg intravenous dose.

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Simultaneous determination of cytosine arabinoside, daunorubicin and etoposide in human plasma

Cited by 26 publications

References 27 publications

Quantitative liquid chromatographic analysis of anthracyclines in biological fluids

Quantitative liquid chromatographic analysis of anthracyclines in biological fluids

Simultaneous determination of cytosine arabinoside and its metabolite, uracil arabinoside, in human plasma using hydrophilic interaction liquid chromatography with UV detection

HPLC‐UV method for quantifying etoposide in plasma and tumor interstitial fluid by microdialysis: application to pharmacokinetic studies

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