Simultaneous Determination of Aceclofenac, Paracetamol and Chlorzoxazone by HPLC in Tablet Dose Form

Pawar, Uttam D.; Naik, Abhijit V.; Sulebhavikar, Aruna V.; Datar, Tirumal A.; Mangaonkar, Kiran V.

doi:10.1155/2009/139484

Cited by 23 publications

(18 citation statements)

References 2 publications

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“…Paracetamol is also used in the management of more severe pain ͑such as postoperative pain͒. 9 Carbon paste ͑CP͒ electrode, which is made up of carbon particles and organic liquid, has been widely applied in the electroanalytical community due to its low cost, ease of fabrication, high sensitivity for detection, and renewable surface. [10][11][12][13][14] Electrodeposition of gold nanoparticles onto the surface of the CP electrode was another strategy to enhance the sensitivity of the immunosensor.…”

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confidence: 99%

Carbon Paste Gold Nanoparticles Sensor for the Selective Determination of Dopamine in Buffered Solutions

Atta

Galal

Abu-Attia

et al. 2010

J. Electrochem. Soc.

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An effective electrochemical sensor for the selective determination of dopamine (DA) in the presence of ascorbic acid (AA) and uric acid (UA) in 0.04molnormalL−1 universal buffer solution (pH 7.4) is introduced. The sensor is based on a carbon paste (CP) electrode modified with gold nanoparticles. In a mixture of DA, AA, and UA, the sensor shows high selective response toward DA and no response for AA or UA. The effect of various experimental parameters including time of deposition of gold nanoparticles on the CP electrode, pH, and scan rate on the voltammetric response of DA was investigated. At the optimum conditions, the concentration of DA was determined using differential pulse voltammetry in a linear range of 1.0×10−7 to 5.0×10−6molnormalL−1 and 5.0×10−6 to 1.3×10−4molnormalL−1 with correlation coefficients of 0.9995 and 0.9988 and a detection limit of 5.9×10−9 and 8.2×10−8molnormalL−1 , respectively. The modified electrode can be used for the determination of DA spiked into human serum samples, and excellent recovery results were obtained over a wide concentration range of DA. Moreover, validation parameters, such as reproducibility, sensitivity, and recovery were evaluated successfully in the determination of DA in diluted human urine.

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confidence: 99%

Carbon Paste Gold Nanoparticles Sensor for the Selective Determination of Dopamine in Buffered Solutions

Atta

Galal

Abu-Attia

et al. 2010

J. Electrochem. Soc.

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“…As was reported in the literature, several methods like liquid chromatography [1, 4, 5, 21], high performance liquid chromatography [3, 8, 10, 12, 17, 18], reversed-phase sequential injection chromatography (SIC) [20], spectrophotometric [7, 9, 13, 16], spectrophotometric with spectrodensitometric [22], spectrofluorimetric [15], capillary electrophoresis [11, 19], colorimetric [2, 6], chronoamperometric [14], thin layer chromatography with spectrophotometric [23], and thin layer chromatography with a fluorescence plate reader [24], and thin layer chromatography (HPTLC) with a densitometry were successfully applied in qualitative and quantitative acetaminophen analysis [25–30]. Generally, HPLC and UV-spectrophotometric methods have been reported in the United States and Polish Pharmacopeias for the analysis of acetaminophen in pharmaceutical preparations [31, 32].…”

Section: Introductionmentioning

confidence: 99%

Validation Thin Layer Chromatography for the Determination of Acetaminophen in Tablets and Comparison with a Pharmacopeial Method

Pyka

Budzisz

Dołowy

2013

BioMed Research International

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Adsorption thin layer chromatography (NP-TLC) with densitometry has been established for the identification and the quantification of acetaminophen in three leading commercial products of pharmaceutical tablets coded as brand: P1 (Product no. 1), P2 (Product no. 2), and P3 (Product no. 3). Applied chromatographic conditions have separated acetaminophen from its related substances, namely, 4-aminophenol and and 4′-chloroacetanilide. UV densitometry was performed in absorbance mode at 248 nm. The presented method was validated by specificity, range, linearity, accuracy, precision, detection limit, quantitative limit, and robustness. The TLC-densitometric method was also compared with a pharmacopeial UV-spectrophotometric method for the assay of acetaminophen, and the results confirmed statistically that the NP-TLC-densitometric method can be used as a substitute method. It could be said that the validated NP-TLC-densitometric method is suitable for the routine analysis of acetaminophen in quantity control laboratories.

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“…The literature survey reveals that PCM is estimated individually or in combination with other drugs by UV [9][10][11][12], HPLC [13][14][15][16][17][18][19][20][21][22], and in plasma [23,24] by RP-HPLC. In addition, LC-MS [25,26], HPTLC [27][28][29][30][31][32][33], and stabilityindicating GC/MS method [34] have been reported.…”

Section: Introductionmentioning

confidence: 99%

Application of HPLC for the Simultaneous Determination of Paracetamol, Chlorzoxazone, and Nimesulide in Pharmaceutical Dosage Form

Tandulwadkar

Nikam

et al. 2012

ISRN Chromatography

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A simple, precise, and accurate reversed-phase liquid chromatographic method has been developed for the simultaneous determination of paracetamol (PCM), chlorzoxazone (CHZ), and nimesulide (NIM) in pharmaceutical dosage form. The chromatographic separation was achieved on a Thermo Hypersil GOLD C18column (250 × 4.6 mm i.d., 5 μm particle size). The mobile phase consisted of water : acetonitrile (55 : 45 v/v). The flow rate was set to 1.2 mL min−1and UV detection was carried out at 275 nm. The retention time () for PCM, CHZ, and NIM was found to be 2.69 ± 0.02, 4.61 ± 0.01, and 9.55 ± 0.02 min, respectively. The validation of the proposed method was carried out for linearity, precision, robustness, limit of detection, limit of quantitation, specificity, and accuracy. The linear dynamic ranges were 32.5–65.0 μg mL−1for PCM, 37.5–75.0 μg mL−1for CHZ, and 10.0–20.0 μg mL−1for NIM. The developed method can be used for routine quality control analysis of titled drugs in pharmaceutical dosage form.

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Simultaneous Determination of Aceclofenac, Paracetamol and Chlorzoxazone by HPLC in Tablet Dose Form

Cited by 23 publications

References 2 publications

Carbon Paste Gold Nanoparticles Sensor for the Selective Determination of Dopamine in Buffered Solutions

Carbon Paste Gold Nanoparticles Sensor for the Selective Determination of Dopamine in Buffered Solutions

Validation Thin Layer Chromatography for the Determination of Acetaminophen in Tablets and Comparison with a Pharmacopeial Method

Application of HPLC for the Simultaneous Determination of Paracetamol, Chlorzoxazone, and Nimesulide in Pharmaceutical Dosage Form

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