Simultaneous detection of antibacterial sulfonamides in a microfluidic device with amperometry

Voltammetric/amperometric screening of compounds of pharmacological interest

“…Glassy carbon (Palomeque andOrtíz 2007, Pfaffen et al 2013), paraffinated graphite (Perantoni et al 2011), carbon paste (Dejmkova et al 2013), boron-doped diamond (Wangfuengkanagul et al 2004) and, particularly, gold (Palaharm et al 2003, Charoenraks et al 2004, Codognoto et al 2010) and screen-printed gold (Masawat and Slater 2007) were reported electrode materials. Electrode modification with metalloporphyrin (Gong et al 2003), cyclodextrin (Lomillo et al 2005), carbon nanotubes ), among others (Won et al 2013), have been reported. Electrode modification strategies are becoming increasingly complicated, thus Lian et al (2012) have reported a molecularly imprinted polymer film at chitosan-platinum nanoparticles/graphene-gold nanoparticles double nanocomposites for sensing erythromycin in real samples.…”

Microfluidic devices for drug discovery and analysis

“…developed a microfl uidic device on glass slides for simultaneous detection of fi ve sulphonamide drugs (Won et al ., 2012). The device was provided with modules for pre-concentration and electrokinetic separation of drugs using the fi eld amplifi ed sample stacking (FASS) and fi eld amplifi ed sample injection (FASI) techniques in two parallel channels (Shiddiky and Shim, 2007).…”

Applications of Conductive Polymers to Electrochemical Sensors and Energy Conversion Electrodes

“…A highly sensitive and robust method for simultaneous detection of five sulfonamide drugs is developed by integrating the preconcentration and separation steps in a microfluidic device. 85) An amperometry is performed for the selective detection of sulfonamides using an Al 2 O 3 -AuNPs modified carbon paste electrode at the end of separation channel. The applicability of the method to the direct analysis of sulfonamides in real meat samples is successfully demonstrated.…”