Voltammetric/amperometric screening of compounds of pharmacological interest

Doménech‐Carbó, Antonio; Carvalho, Leandro Machado de; Martini, Mariele; Cebrián‐Torrejón, Gerardo

doi:10.1515/revac-2013-0027

Cited by 18 publications

(11 citation statements)

References 296 publications

(190 reference statements)

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“…Method [18][19][20][21][22] Linearity: Linearity of the method was determined by constructing calibration curves. Standard solutions of atorvastatin and Fenofibrate of different concentrations level were used for this purpose.…”

Section: Validation Of Developed Analyticalmentioning

confidence: 99%

Rp-HPLC Method Development and Validation for Simultaneous Estimation of Atorvestatin Calcium and Fenofibrate in Bulk and Formulation

Deshmukh¹,

Patil²

2021

JPRI

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A reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of atorvastatin and Fenofibrate in bulk and pharmaceutical dosage forms. The determination was performed by using Waters Symmetry C18 (250×4.6mm×5µ) as column stationary phase and Methanol: Acetonitrile: Water in the ratio of (70:10:20 %v/v) as mobile phase. The flow rate of mobile phase was optimized as 1mL/min and effluents were monitored at 274 nm. The retention time of atorvastatin and Fenofibrate were found as 4.15 min and 8.10 min respectively. The method shows linearity concentration ranges between 4-30 μg/mL and 80-400 μg/mL respectively. The developed method was validated for specificity, precision, linearity, accuracy, robustness, Ruggedness, LOD and LOQ. Recovery of atorvastatin and Fenofibrate in formulations was found to be 100.52% and 99.92% respectively which conforms the non-interferences of the excipients in the formulation. the proposed RP- HPLC method can be used for the simultaneous determination of these two drugs in bulk and formulation.

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Section: Validation Of Developed Analyticalmentioning

confidence: 99%

Rp-HPLC Method Development and Validation for Simultaneous Estimation of Atorvestatin Calcium and Fenofibrate in Bulk and Formulation

Deshmukh¹,

Patil²

2021

JPRI

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“…Electrochemical methods have emerged as an answer to overcome these disadvantages, since they are an attractive option for pharmaceutical analysis, because electroanalytical techniques are characterized by their moderate cost, simplicity and portability . In addition, the study of the redox properties of the drugs can give an idea of their metabolism, in vivo or their pharmacological activity .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO₂Electrode. Application in Pharmaceutical Preparations

et al. 2017

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An electroanalytical method using square wave voltammetry (SWV) is proposed for the quantification of Guanine (G), 6‐Thioguanine (TG), Acyclovir (Acy) and Ganciclovir (Gan) in different types of pharmacological samples. In addition, for the first time, a study of the electrochemical behavior (using cyclic voltammetry, CV) of guanine and its pharmacological derivatives on fluoride doped oxide (FTO) electrodes was carried out. The study of CV potential scanning demonstrated the charge transfer process was diffusion controlled and the diffusion coefficient was determined for all the studied products. Besides, electrochemical parameters, such as transfer coefficient, heterogeneous charge transfer constant and the number of electrons transferred (e) were determined namely, 4e for TG and 2e for G, Acy and Gan. SWV studies at pH 4 for G and 2 for TG, Acy and Gan showed linear ranges between 4.0×10−6 and 40.0×10−6 mol L−1, with detection limits of 0.91×10−6 for G, and 1.50×10−6 for TG, 1.25×10−6 for Acy and 0.45×10−6 mol L−1 for Gan. The method presents sensitivity and stability appropriate to be employed in quality control and routine quantification of drugs in pharmaceutical formulations.

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“…Electrochemical methods are powerful and versatile tools that offer high sensitivity, accuracy, precision and a linear dynamic range on a low cost of instrumentation [15], [16] that can be successfully applied to detect pharmaceuticals residues from water.…”

Section: Introductionmentioning

confidence: 99%

Fast Simultaneous Electrochemical Detection of Tetracycline and Fluoxetine in Water

Ardelean

Pode

Schoonman

et al. 2017

WIT Transactions on Ecology and the Environment

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The electrochemical methods-based protocol for simultaneous detection of tetracycline (TC) from antibiotics class and fluoxetine (FXT) from anti-depressive pharmaceuticals class, which belongs to emerging pollutants from water, was developed in this study using carbon nanofiber-epoxy composite electrode (CNF). The electrochemical behaviour of each pharmaceutical on CNF was considered the basis for simultaneous detection of both pharmaceuticals from water. TC electrooxidation on CNF occurred in two steps and, consequently, two detection potentials are considered. FXT electrooxidation occurred in one step that is overlaid to the first step of TC detection, this step being considered as cumulative for both pharmaceuticals. Each electrochemical method of cyclic voltammetry (CV) and differential-pulsed voltammetry (DPV) allowed detecting cumulative presence of TC and FXT at the detection potential ranged between 0.65 and 0.815 V vs. SCE and the selective detection of TC at the detection potential ranged between 0.956 and 1.14 V vs. SCE. The electroanalytical parameters related to the lowest limit of detection and sensitivity recommended this electrode to exhibit the potential for practical applications in the electrochemical detection of certain pharmaceuticals as emerging pollutants from water.

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Voltammetric/amperometric screening of compounds of pharmacological interest

Cited by 18 publications

References 296 publications

Rp-HPLC Method Development and Validation for Simultaneous Estimation of Atorvestatin Calcium and Fenofibrate in Bulk and Formulation

Rp-HPLC Method Development and Validation for Simultaneous Estimation of Atorvestatin Calcium and Fenofibrate in Bulk and Formulation

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO₂Electrode. Application in Pharmaceutical Preparations

Fast Simultaneous Electrochemical Detection of Tetracycline and Fluoxetine in Water

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Voltammetric/amperometric screening of compounds of pharmacological interest

Cited by 18 publications

References 296 publications

Rp-HPLC Method Development and Validation for Simultaneous Estimation of Atorvestatin Calcium and Fenofibrate in Bulk and Formulation

Rp-HPLC Method Development and Validation for Simultaneous Estimation of Atorvestatin Calcium and Fenofibrate in Bulk and Formulation

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO2Electrode. Application in Pharmaceutical Preparations

Fast Simultaneous Electrochemical Detection of Tetracycline and Fluoxetine in Water

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Product

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Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO₂Electrode. Application in Pharmaceutical Preparations