Microfluidic devices for drug discovery and analysis

Kochhar, Jaspreet Singh; Chan, Sui Yung; Ong, Pei Shi; Lee, Won Gu; Kang, Lifeng

doi:10.1533/9780857097040.2.231

Cited by 6 publications

(3 citation statements)

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of these topics is no doubt OOC systems. 1 An organ-onchip is a miniature micro-engineering system that combines biomaterials technology, cell biology and engineering to reproduce the structural and functional attributes of human tissue on a small-scale platform. [2][3][4] Microtechnologies permit the fabrication of cell culture chambers and provision and removal of nutrients and gases with micrometer precision, driving to the simulation of controlled biological environments where biological fluid continuously enters slowly but steadily, thus simulating the physiology of organs and tissues.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tuneable hydrogel patterns in pillarless microfluidic devices

Olaizola-Rodrigo,

Palma-Florez,

Ranđelović

et al. 2024

Lab Chip

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…One of these topics is no doubt OOC systems. 1 An organ-on-chip is a miniature micro-engineering system that combines biomaterials technology, cell biology and engineering to reproduce the structural and functional attributes of human tissue on a small-scale platform. 2–4…”

Section: Introductionmentioning

confidence: 99%

Tuneable hydrogel patterns in pillarless microfluidic devices

Olaizola-Rodrigo,

Palma-Florez,

Ranđelović

et al. 2024

Lab Chip

View full text Add to dashboard Cite

show abstract

“…In addition, using microfluidic devices to generate MTNs at microscale level allows using minimal volume of ingredients with minimal losses, contamination, or waste generation [28,29]. Finally, the recent advances in microfluidic technologies and low cost materials allow developing efficient and inexpensive devices for drug release applications [30,31]. The concept of magnetically triggered drug release is presented in Figure 1: after being fabricated in a microfluidic system, the MTNs are collected and washed before they are loaded with a hydrophilic dye (used as a liquid drug model).…”

Section: Introductionmentioning

confidence: 99%

Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery

Yassine

Alfadhel

et al. 2016

International Journal of Polymer Science

View full text Add to dashboard Cite

Responsive microgel poly(N-isopropylacrylamide) or PNIPAM is a gel that can swell or shrink in response to external stimuli (temperature, pH, etc.). In this work, a nanocomposite gel is developed consisting of PNIPAM and magnetic iron oxide nanobeads for controlled release of liquids (like drugs) upon exposure to an alternating magnetic field. Microparticles of the nanocomposite are fabricated efficiently with a monodisperse size distribution and a diameter ranging from 20 to 500 µm at a rate of up to 1 kHz using a simple and inexpensive microfluidic system. The nanocomposite is heated through magnetic losses, which is exploited for a remotely stimulated liquid release. The efficiency of the microparticles for controlled drug release applications is tested with a solution of Rhodamine B as a liquid drug model. In continuous and pulsatile mode, a release of 7% and 80% was achieved, respectively. Compared to external thermal actuation that heats the entire surrounding or embedded heaters that need complex fabrication steps, the magnetic actuation provides localized heating and is easy to implement with our microfluidic fabrication method.

show abstract

Lipid Microfluidic Biomimetic Models for Drug Screening: A Comprehensive Review

Fernandes,

Cardoso,

Lanceros‐Méndez

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Developing new drugs is a complex, time‐consuming, and expensive process, essential to identify potential pharmacokinetic issues in the early stages to avoid investment in nonpromising candidates. Nearly half of all drug targets and key drug‐metabolizing enzymes are found in intracellular environments, compartmentalized by semipermeable barriers, the cell membranes. Inspired by their lipidic bilayer structure, lipid‐based biomimetic platforms are being developed to understand the biochemical and biophysical processes at the cellular membrane level. Considering the pharmaceutical industry's demands for efficient in vitro high throughput screening tools, microfluidic technology emerges as a promising solution to address challenges in lipid biomimetic models for screening applications. This involves the transformation of commonly used lipid‐based biomimetic models, like supported lipid bilayers and lipid vesicles, to miniaturized approachs and their evolution into a new generation of bilayer models. These include pore‐suspended and free‐standing lipid bilayers, black lipid membranes, and droplet interface bilayers. This review provides an overview of both generations of lipid biomimetic models used in drug‐membrane screening applications. Moreover, it delves into the intricacies of their production through microfluidic approaches and examines their screening applications in drug‐membrane interaction. The review concludes with a critical analysis of potential future directions in this rapidly evolving field.

show abstract

Microfluidic devices for drug discovery and analysis

Cited by 6 publications

References 172 publications

Tuneable hydrogel patterns in pillarless microfluidic devices

Tuneable hydrogel patterns in pillarless microfluidic devices

Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery

Lipid Microfluidic Biomimetic Models for Drug Screening: A Comprehensive Review

Contact Info

Product

Resources

About