Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery

Yassine, Omar; Li, Erqiang; Alfadhel, Ahmed; Zaher, Amir; Kavaldzhiev, Mincho; Thoroddsen, Sigurður T.; Kosel, Jürgen

doi:10.1155/2016/1219469

Cited by 7 publications

(5 citation statements)

References 52 publications

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“…Switching Functionality of Magnetic Supraparticles. Magnetic supraparticles and composites can be “switched” through external fields through several approaches covered in excellent reviews. − An AC magnetic field can inductively heat the magnetic nanoscale building blocks within the supraparticle, for example to release drugs or treat tumors via hyperthermia. − Thomas et al reported on a system where magnetic nanoparticles acted as “plugs” for a porous particle system that could be magnetically removed, thus releasing the drugs (Figure d) …”

Section: Discussionmentioning

confidence: 99%

Supraparticles: Functionality from Uniform Structural Motifs

et al. 2018

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Under the right process conditions, nanoparticles can cluster together to form defined, dispersed structures, which can be termed supraparticles. Controlling the size, shape, and morphology of such entities is a central step in various fields of science and technology, ranging from colloid chemistry and soft matter physics to powder technology and pharmaceutical and food sciences. These diverse scientific communities have been investigating formation processes and structure/property relations of such supraparticles under completely different boundary conditions. On the fundamental side, the field is driven by the desire to gain maximum control of the assembly structures using very defined and tailored colloidal building blocks, whereas more applied disciplines focus on optimizing the functional properties from rather ill-defined starting materials. With this review article, we aim to provide a connecting perspective by outlining fundamental principles that govern the formation and functionality of supraparticles. We discuss the formation of supraparticles as a result of colloidal properties interplaying with external process parameters. We then outline how the structure of the supraparticles gives rise to diverse functional properties. They can be a result of the structure itself (emergent properties), of the colocalization of different, functional building blocks, or of coupling between individual particles in close proximity. Taken together, we aim to establish structure-property and process-structure relationships that provide unifying guidelines for the rational design of functional supraparticles with optimized properties. Finally, we aspire to connect the different disciplines by providing a categorized overview of the existing, diverging nomenclature of seemingly similar supraparticle structures.

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Section: Discussionmentioning

confidence: 99%

Supraparticles: Functionality from Uniform Structural Motifs

et al. 2018

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“…The magnetoresponsive nanocomposites were triggered with a frequency of 600 kHz and an AMF strength of 72 mT, and 80% release efficiency was obtained within 100 min. [ 89 ] Superparamagnetic iron oxide nanocarriers (SPIONS) have been used as nanodrug carriers and delivered using a magnetically controlled microfluidic platform. [ 90 ] On‐demand release of docetaxel (DTX), an antiproliferative drug, under the actuation of a magnetic field, has been demonstrated inside the PDMS MEMS device.…”

Section: In Vitro And/or In Vivo Applications Of Different Strategic ...mentioning

confidence: 99%

Nanocarrier‐Based Drug Delivery Systems using Microfluidic‐Assisted Techniques

Alam

2023

Advanced NanoBiomed Research

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Nanocarrier‐mediated drug delivery in life science and patient care is now highly recognized and has gained significant traction in pharmaceuticals for clinical applications. Besides, the incorporation of microfluidic technology for the synthesizing and delivery of nanocarriers facilitates preclinical drug testing under biomimicking physiological conditions, which further increases the prospect of nanocarrier drug delivery systems in clinical use. Indeed, an inherent amenability of microfluidics shows fine‐tuned manipulation and controlled release of nanocarrier drugs in a spatiotemporal manner. The progress of microfluidic‐assisted potential drug delivery platforms is reviewed and summarized with a focus on factors determining the design of novel nanodrug delivery microfluidic systems, on‐chip functionalization and synthesis mechanisms of nanodrugs, and stimulation‐responsive and organ‐specific drug delivery platforms, including different challenges associated with developing platforms in benchtop research that hinder platforms’ clinical translation. Moreover, the commercial scenario and prospects of the microfluidic nanodrug delivery platforms are evaluated, and further predictive suggestions are provided for developing multitargeting microfluidic/organ‐on‐a‐chip nanodrug delivery platforms and overcoming the challenges associated with commercialization. This review recognizes that although numerous reports have reinforced the promise of microfluidic nanodrug delivery platforms, much remains to be done in lab and benchtop works to realize it in clinical practice through commercialization.

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“…NWs can also serve as remote triggers for other drug-carriers to release the drug. Poly (N-isopropylacrylamide) (PNIPAM) is a micro-gel that swells below a certain temperature and shrinks at a higher temperature, thereby it absorbs and expels a solvent (drug), respectively [160]. When NWs are embedded into PNIPAM, an external magnetic field (kHz frequency range) causes them to vibrate resulting in friction (in addition to possible hysteresis losses) and therefore heating, triggering the release of the solvent.…”

Section: A Drug Deliverymentioning

confidence: 99%

Cylindrical Magnetic Nanowires Applications

et al. 2021

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Cylindrical magnetic nanowires feature unique properties, which make them attractive for fundamental research as well as novel applications. These one-dimensional structures introduce a pronounced shape anisotropy that together with material selection can strongly affect the magnetic properties and can be tuned by incorporating segments of different materials or diameters along the length. They attract a large interest in the scientific community, ranging from physicists to material scientists to bioengineers. Consequently, these nanowires are developed for and employed in very diverse applications in medicine, biology, data and energy storage, catalysis or microwave electronics, among others. In this review we investigate the most active emerging applications of cylindrical nanowires grown in alumina templates by electrochemical deposition. This method has several key features, including low cost and a high level of control over the design. A fundamental property that distinguishes those applications is the operating frequency, which we chose to apply as an underlying structure for this review. With this we attempt to provide a wide and organized view of applications based on cylindrical magnetic nanowires with a focus on tailored physical and chemical properties.

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Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery

Cited by 7 publications

References 52 publications

Supraparticles: Functionality from Uniform Structural Motifs

Supraparticles: Functionality from Uniform Structural Motifs

Nanocarrier‐Based Drug Delivery Systems using Microfluidic‐Assisted Techniques

Cylindrical Magnetic Nanowires Applications

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