Simultaneous BOLD-fMRI and constant infusion FDG-PET data of the resting human brain

Abstract

Simultaneous [18 F]-fluorodeoxyglucose positron emission tomography and functional magnetic resonance imaging (FDG-PET/fMRI) provides the capability to image two sources of energetic dynamics in the brain – cerebral glucose uptake and the cerebrovascular haemodynamic response. Resting-state fMRI connectivity has been enormously useful for characterising interactions between distributed brain regions in humans. Metabolic connectivity has recently emerged as a complementary measure to investigate brain network dynamics. Functional PET (fPET) is a new approach for measuring FDG uptake with high temporal resolution and has recently shown promise for assessing the dynamics of neural metabolism. Simultaneous fMRI/fPET is a relatively new hybrid imaging modality, with only a few biomedical imaging research facilities able to acquire FDG PET and BOLD fMRI data simultaneously. We present data for n = 27 healthy young adults (18–20 yrs) who underwent a 95-min simultaneous fMRI/fPET scan while resting with their eyes open. This dataset provides significant re-use value to understand the neural dynamics of glucose metabolism and the haemodynamic response, the synchrony, and interaction between these measures, and the development of new single- and multi-modality image preparation and analysis procedures.

Virtual Reality for Neurorehabilitation and Cognitive Enhancement

“…Direct evidence for the underlying molecular changes at the level of individual neurons, however, is beyond the reach of current methods for functional brain imaging. Nevertheless, electroencephalography (EEG) [ 35 , 36 ], magnetoencephalography (MEG) [ 37 , 38 ], near-infrared spectroscopy (NIRS) [ 39 , 40 ], positron emission tomography (PET) [ 41 , 42 , 43 ], and magnetic resonance imaging (MRI) [ 44 , 45 , 46 ] can resolve functional brain states with macroscopic resolution (e.g., EEG has a temporal resolution of milliseconds and MRI has a spatial resolution of millimeters) that can detect cumulative changes in brain volume or excitability acquired over several weeks of training or rehabilitation.…”

Monash DaCRA fPET-fMRI: A DAtaset for Comparison of Radiotracer Administration for high temporal resolution functional FDG-PET

“…Using fPET data acquired simultaneously with (non-functional) MRI (i.e., MRI/fPET), Villien et al was able to estimate a general linear model response for blocked stimuli presented 5-10mins apart. Subsequent studies have extended these findings, and achieved fPET temporal resolutions of 1-minute[6,7,9–11] or less (12sec[5]; 16sec[12–14]; 30sec[15]).…”

“…Although very few imaging facilities world-wide currently possess the infrastructure and technical skill to acquire fPET-fMRI data, the rapid increase in publication (e.g. [5][6][7][10][11][12]14,15,21,32,33]) and reuse metrics of publicly available datasets [34,35] attests to the value the international neuroscience community places on this novel data type. The Monash DaCRA fPET-fMRI dataset is the only publicly available dataset that allows comparison of radiotracer administration protocols for fPET-fMRI.…”

Metabolic and functional connectivity provide unique and complementary insights into cognition-connectome relationships

“…These negative cognition-connectivity associations can reflect either reduced positive associations or anti-correlations (Hearne et al, 2016). There is also the possibility that these scattered negative loadings (Figure S2) might be a pre-processing epiphenomenon (Jamadar et al, 2020). Future research is needed to investigate whether the small fraction of negative associations in the metabolic connectome are behaviourally meaningful.…”