Monash DaCRA fPET-fMRI: A DAtaset for Comparison of Radiotracer Administration for high temporal resolution functional FDG-PET

Abstract

Background: Functional [18F]-fluorodeoxyglucose positron emission tomography (FDG-fPET) is a new approach for measuring glucose uptake in the human brain. The goal of FDG-fPET is to maintain a constant plasma supply of radioactive FDG in order to track, with high temporal resolution, the dynamic uptake of glucose during neuronal activity that occurs in response to a task or at rest. FDG-fPET has most often been applied in simultaneous BOLD-fMRI/FDG-fPET (blood oxygenation level dependent functional MRI fluorodeoxyglucose functional positron emission tomography) imaging. BOLD-fMRI/FDG-fPET provides the capability to image the two primary sources of energetic dynamics in the brain, the cerebrovascular haemodynamic response and cerebral glucose uptake. Findings: In this Data Note, we describe an open access dataset, Monash DaCRA fPET-fMRI, which contrasts three radiotracer administration protocols for FDG-fPET: bolus, constant infusion, and hybrid bolus/infusion. Participants (n=5 in each group) were randomly assigned to each radiotracer administration protocol and underwent simultaneous BOLD-fMRI/FDG-fPET scanning while viewing a flickering checkerboard. The Bolus group received the full FDG dose in a standard bolus administration; the Infusion group received the full FDG dose as a slow infusion over the duration of the scan, and the Bolus-Infusion group received 50% of the FDG dose as bolus and 50% as constant infusion. We validate the dataset by contrasting plasma radioactivity, grey matter mean uptake, and task-related activity in the visual cortex. Conclusions: The Monash DaCRA fPET-fMRI dataset provides significant re-use value for researchers interested in the comparison of signal dynamics in fPET, and its relationship with fMRI task-evoked activity.

Monash DaCRA fPET-fMRI: A dataset for comparison of radiotracer administration for high temporal resolution functional FDG-PET

“…Detailed information about the data records available for the Monash DaCRA fPET-fMRI dataset (OpenNeuro ds003397) [ 17 ] is reported in Table 1 . Table 2 reports the software used in this article.…”

“…Simultaneous MR-PET is a nascent technique, opening up many opportunities for scientific discovery, methods development, and signal optimization of dual-modality data. Although few imaging facilities worldwide currently possess the infrastructure and technical skill to acquire fPET-fMRI data, the rapid increase in publication (e.g., [ 5–7 , 10–12 , 15 , 28 , 40 ]) and reuse metrics of publicly available datasets [ 41 , 42 ] attests to the value that the international neuroscience community places on this novel data type. The Monash DaCRA fPET-fMRI dataset is the only publicly available dataset that allows comparison of radiotracer administration protocols for fPET-fMRI.…”

“…Open source fPET-fMRI datasets provide many opportunities for progress in methods development: in the acquisition of the images, image reconstruction, data preparation, and analysis. The present dataset provides the opportunity to explore radiotracer dynamics of the constant-infusion administration approach; the Monash rsfPET-fMRI dataset [ 41 ] provides the opportunity to explore resting-state dynamics in healthy controls; and the Monash visfPET-fMRI dataset [ 42 ] provides the opportunity to explore responses to visual checkerboard stimulation with low-dose constant-infusion administration. The complementary nature of haemodynamic and “glucodynamic” responses to brain activity also presents an excellent opportunity for neuroscientific discovery.…”

“…All data supporting this work are openly available in the OpenNeuro database as dataset No. ds003397, under a CC0 public domain license [ 17 ].…”

“…The aim in acquiring the Monash Dataset for Comparison of Radiotracer Administration fPET-fMRI (“Monash DaCRA fPET-fMRI”) [ 17 ] was to contrast different radiotracer administration protocols for fPET data acquisition. The majority of fPET studies have used a constant-infusion delivery protocol [ 6 , 7 , 9–11 , 14 ], where the entire dose of radiation is provided as an infusion over the course of the scan.…”