Simultaneous biplane high speed 1000 fps x-ray angiography (HSAngio)

Nagesh, Swetadri Vasan Setlur; Shields, Allison; Wu, Xinlin; Ionita, Ciprian N.; Bednarek, Daniel R.; Rudin, Stephen

doi:10.1117/12.2611554

Cited by 6 publications

(9 citation statements)

References 4 publications

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“…However, the relative assessment of BAT within difference regions of the same model provide valuable information about the contrast transport through the ROI. Improved methods of projecting the 3D volumetric data, along with advancements in biplane HSA methods can help mitigate this effect and improve accuracy of API and TDC analysis 24 . The use of CFD and SA such as the current work provides the ability to create detailed, high-resolution synthetic data in a controlled and systematic approach.…”

Section: Discussionmentioning

confidence: 99%

Investigating angiographic injection parameters for cerebral aneurysm hemodynamic characterization using patient-specific simulated angiograms

White

Shields

Nagesh

et al. 2023

Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging

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Cerebral aneurysm (CA) rupture is one of the major causes of hemorrhagic stroke. During endovascular therapy (ET), neurointerventionalists rely on qualitative image sequences and do not have access to crucial quantitative hemodynamic information. Quantifying angiographic image sequences can provide vital information, but it is not possible to perform this in a controlled manner in vivo. Computational fluid dynamics (CFD) is a valuable tool capable of providing high fidelity quantitative data by replicating the blood flow physics within the cerebrovasculature. In this work, we use simulated angiograms (SA) to quantify the hemodynamic interaction with a clinically utilized contrast agent. SA enables extraction of time density curves (TDC) within the desired region of interest to analyze hemodynamic parameters such as time to peak (TTP) and mean transit time (MTT) within the aneurysm. We present on the quantification of several hemodynamic parameters of interest for multiple, clinically-relevant scenarios such as variable contrast injection duration and bolus volumes for 7 patient-specific CA geometries. Results indicate that utilizing these analyses provides valuable hemodynamic information relating vascular and aneurysm morphology, contrast flow conditions and injection variability. The injected contrast circulates for multiple cardiac cycles within the aneurysmal region, especially for larger aneurysms and tortuous vasculature. The SA approach enables determination of angiographic parameters for each scenario. Together, these have the potential to overcome the existing barriers in quantifying angiographic procedures in vitro or in vivo, and can provide clinically valuable hemodynamic insights for CA treatment.

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Section: Discussionmentioning

confidence: 99%

Investigating angiographic injection parameters for cerebral aneurysm hemodynamic characterization using patient-specific simulated angiograms

White

Shields

Nagesh

et al. 2023

Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging

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“…Current research efforts include the development of a biplane HSA system, where depth-dependent flow information could be better recovered by combining velocity distributions from two planes. 38 Additionally, the fluid-tracer used in this experiment is not safe for in-patient diagnostic use. Ethiodol was chosen in this instance due to its nonsoluble droplet properties, which is useful in calibrating the OFM with another in-vitro method, like X-PIV, when high velocities and erratic flow patterns are expected.…”

Section: Study Limitationsmentioning

confidence: 99%

Section: Study Limitationsmentioning

confidence: 99%

Application of 1,000 fps High-Speed Angiography to In-Vitro Hemodynamic Evaluation of Left Ventricular Assist Device Outflow Graft Configurations

et al. 2023

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Left ventricular assist device (LVAD)-induced hemodynamics are characterized by fast-moving flow with large variations in velocity, making quantitative assessments difficult with existing imaging methods. This study demonstrates the ability of 1,000 fps high-speed angiography (HSA) to quantify the effect of the surgical implantation angle of a LVAD outflow graft on the hemodynamics within the ascending aorta in vitro. High-speed angiography was performed on patientderived, three-dimensional-printed optically opaque aortic models using a nonsoluble contrast media, ethiodol, as a flow tracer. Outflow graft configuration angles of 45° and 90° with respect to the central aortic axis were considered. Projected velocity distributions were calculated from the high-speed experimental sequences using two methods: a physics-based optical flow algorithm and tracking of radio-opaque particles. Particle trajectories were also used to evaluate accumulated shear stress. Results were then compared with computational fluid dynamics (CFD) simulations to confirm the results of the high-speed imaging method. Flow patterns derived from HSA coincided with the impingement regions and recirculation zones formed in the aortic root as seen in the CFD for both graft configurations. Compared with the 45° graft, the 90° configuration resulted in 81% higher two-dimensionalprojected velocities (over 100 cm/s) along the contralateral wall of the aorta. Both graft configurations suggest elevated accumulated shear stresses along individual trajectories. Compared with CFD simulations, HSA successfully characterized the fast-moving flow and hemodynamics in each LVAD graft configuration in vitro, demonstrating the potential utility of this technology as a quantitative imaging modality. ASAIO

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“…Previous studies have shown that additional flow information can be obtained by introducing simultaneous (frame-correlated) biplane image sequences. 3 Standard biplane x-ray imaging is used to visualize the static 3-dimensional vascular structure; the proposed high-speed method enables visualization of flow detail in two views, where each detector acquisition is synchronized to the other. Compared to previous work, which highlighted the beginning of dual simultaneous biplane acquisitions, this work highlights the improvement of non-orthogonal acquisitions for vessel visualization and improved visualization of flow dynamics.…”

Section: Introductionmentioning

confidence: 99%

Multi-angled simultaneous biplane High-Speed Angiography (HSA) of patient-specific 3D-printed aneurysm phantoms using 1000 fps CdTe Photon-Counting Detectors (PCD’s )

Vanderbilt

Shields

et al. 2023

Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging

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1000 fps HSA enables visualization of flow details, which may be important in accurately guiding interventional procedures; however, single-plane imaging may lack clear visualization of vessel geometry and flow detail. The previously presented high-speed orthogonal biplane imaging may overcome these limitations but may still result in foreshortening of vessel morphology. In certain morphologies, acquiring two non-orthogonal biplane projections at multiple angles can provide better flow detail rather than a standard orthogonal biplane acquisition. Flow studies of aneurysm models were performed, where simultaneous biplane acquisitions at various angles separating the two detector views allowed for better evaluation of morphology and flow. 3D-printed, patient-specific internal carotid artery aneurysm models were imaged with various non-orthogonal angles between the two high-speed photon-counting detectors (7.5 cm x 5 cm FOV) to provide frame-correlated simultaneous 1000-fps image sequences. Fluid dynamics were visualized in multi-angled planes of each model using automated injections of iodine contrast media. The resulting dual simultaneous frame-correlated 1000-fps acquisitions from multiple planes of each aneurysm model provided improved visualization of complex aneurysm geometries and flow streamlines. Multi-angled biplane acquisitions with frame correlation allows for further understanding of aneurysm morphology and flow details: additionally, the ability to recover fluid dynamics at depth enables accurate analysis of 3D flow streamlines, and it is expected that multiple-planar views will enable better volumetric flow visualization and quantification. Such better visualization has the potential to improve interventional procedures.

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Simultaneous biplane high speed 1000 fps x-ray angiography (HSAngio)

Cited by 6 publications

References 4 publications

Investigating angiographic injection parameters for cerebral aneurysm hemodynamic characterization using patient-specific simulated angiograms

Investigating angiographic injection parameters for cerebral aneurysm hemodynamic characterization using patient-specific simulated angiograms

Application of 1,000 fps High-Speed Angiography to In-Vitro Hemodynamic Evaluation of Left Ventricular Assist Device Outflow Graft Configurations

Multi-angled simultaneous biplane High-Speed Angiography (HSA) of patient-specific 3D-printed aneurysm phantoms using 1000 fps CdTe Photon-Counting Detectors (PCD’s )

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