Simulation Analysis of the Influence of Nozzle Structure Parameters on Material Controllability

Liu, Huanbao; Zheng, Guangming; Cheng, Xiang; Yang, Xianhai; Guo, Zhao

doi:10.3390/mi11090826

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Coaxial focused wrapping technology has also been applied in the 3D printing of extrusion molding for the forming and manufacturing of vascular structures. The extrusion molding 3D printing methods all adopt coaxial focusing printing methods, such as "dual-material synchronous extrusion" [16,17] and "micro-channel extrusion" [18,19], to realize the printing and molding of the vessel structure. However, because the density and uniformity of cells in the vessel-like structure are mainly determined by the density and uniformity of cells in the biological materials, it is not easy to meet the requirements of cell microsphere shaping and printing-on-demand.…”

Section: Introductionmentioning

confidence: 99%

Theoretical and Experimental Research on Multi-Layer Vessel-like Structure Printing Based on 3D Bio-Printing Technology

et al. 2021

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Cardiovascular disease is the leading cause of death worldwide. Traditional autologous transplantation has become a severe issue due to insufficient donors. Artificial blood vessel is an effective method for the treatment of major vascular diseases, such as heart and peripheral blood vessel diseases. However, the traditional single-material printing technology has been unable to meet the users’ demand for product functional complexity, which is not only reflected in the field of industrial manufacturing, but also in the field of functional vessel-like structure regeneration. In order to achieve the printing and forming of multi-layer vessel-like structures, this paper carries out theoretical and experimental research on the printing and forming of a multi-layer vessel-like structure based on multi-material 3D bioprinting technology. Firstly, theoretical analysis has been explored to research the relationship among the different parameters in the process of vessel forming, and further confirm the synchronous relationship among the extrusion rate of material, the tangential speed of the rotating rod, and the movement speed of the platform. Secondly, sodium alginate and gelatin have been used as the experimental materials to manufacture the vessel-like structure, and the corrected parameter of the theoretical analysis is further verified. Finally, the cell-loaded materials have been printed and analyzed, and cell viability is more than 90%, which provides support for the research of multi-layer vessel-like structure printing.

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Section: Introductionmentioning

confidence: 99%

Theoretical and Experimental Research on Multi-Layer Vessel-like Structure Printing Based on 3D Bio-Printing Technology

et al. 2021

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Design and Fabrication of In-House Nozzle System to Extrude Multi-Hydrogels for 3D Bioprinting Process

Habib,

Quigley,

Sarah

et al. 2023

Journal of Manufacturing Science and Engineering

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The field of 3D bio-printing is rapidly expanding as researchers strive to create functional tissues for medical and pharmaceutical purposes. The ability to print multiple materials, each containing various living cells, brings us closer to achieving tissue regeneration. In a previous study, we designed a Y-shaped nozzle connector system that allowed for continuous deposition of multiple materials. This system was made of plastic and had a fixed switching angle, rendering it suitable for a single use. In this paper, we present the updated version of our nozzle system, which includes a range of angles (30°, 45°, 60°, and 90° degrees) between the two materials. We used stainless steel as the fabrication material and recorded the overall material switching time, comparing the effects of the various angles. Our previously developed hybrid hydrogel, which comprised 4% Alginate and 4% Carboxymethyl Cellulose (CMC), was used as a test material to flow through the nozzle system. The in-house fabricated nozzle connectors are reusable, sterile, and easy to clean, ensuring a smooth material transition and flow.

show abstract

Simulation Analysis of the Influence of Nozzle Structure Parameters on Material Controllability

Cited by 2 publications

References 28 publications

Theoretical and Experimental Research on Multi-Layer Vessel-like Structure Printing Based on 3D Bio-Printing Technology

Theoretical and Experimental Research on Multi-Layer Vessel-like Structure Printing Based on 3D Bio-Printing Technology

Design and Fabrication of In-House Nozzle System to Extrude Multi-Hydrogels for 3D Bioprinting Process

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