Simplifying likelihood ratios

McGee, Steven

doi:10.1046/j.1525-1497.2002.10750.x

Cited by 771 publications

(671 citation statements)

References 9 publications

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“…These values suggest that negative results of FDG-PET could not be used alone as a justification (McGee, 2002). False-negative and the unsatisfactory sensitivity may be given in following conditions.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of 18F-FDG-PET in Patients with Testicular Cancer: a Meta-analysis

Zhao

Ma²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of 18F-FDG-PET in Patients with Testicular Cancer: a Meta-analysis

Zhao

Ma²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Although this analysis is rarely used, it has more important benefits than sensitivity and specificity measurements alone and is the best way of measuring and expressing diagnostic accuracy. LR analysis can also be used for mental health screening instruments (Akobeng, 2006;Attia, 2003;McGee, 2002;Schmitz, Kruse & Tress, 2002;Sonis, 1999).…”

Section: The Data Analysismentioning

confidence: 99%

Screening for the hyperkinetic disorder by using strength and difficulties questionnaire teacher-report (SDQ-TR) in Indonesia school-aged children

Siregar¹,

Wimbarti²

2018

GJPR

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The aim of the research was to examine the validity of strength and difficulties questionnaire teacher-report (SDQ-TR) to screen hyperkinetic disorder in Indonesia school-aged children. The SDQ-TR was administrated to the teacher of representative samples of 222 elementary school children (7-14 years old). The SDQ-TR hyperactivity-inattention subscale scores were compared with the clinical diagnostic classification from clinical psychologists. The validity of the screening result was analysed using receiver operating characteristic (ROC), likelihood ratio (LR) and Chi-Square. Based on the analysis of ROC and LR by using cutoff point ≥ 7, obtained prevalence of hyperkinetic disorder was equal to 34.23% with sensitivity 72.4% and specificity 73.3%. Positive and Negative LR were 2.71 and 0.38. The Chi-Square analysis showed that there was a positive correlation between clinical psychologists' diagnosis and the SDQ-TR screening result. The study showed that SDQ-TR was a valid instrument for screen hyperkinetic disorder in Indonesia school-aged children.

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“…This finding raises the possibility that an embryo with a low probability of implantation does not influence or minimally influences the chemical profile of the medium. Likelihood ratios were calculated for assessing the value of performing a diagnostic test, by measuring sensitivity, specificity, predictive values, and receiver operating characteristic area under the curve of 0.94 (95% CI 0.92-0.96) (McGee 2002, Kentsis et al 2012. The calibration likelihood ratios for positive and negative were zero.…”

Section: Data Analysis Of Mass Spectramentioning

confidence: 99%

“…Four samples of equilibrated culture medium without embryos were used as controls and were analyzed by the previously developed multivariate method as a check test, besides the calibration or validation set. Likelihood ratios were calculated for assessing the value of performing a diagnostic test, by measuring sensitivity, specificity, and predictive values (McGee 2002, Kentsis et al 2012.…”

Section: Multivariate Statistical Analysismentioning

confidence: 99%

Prediction of embryo implantation potential by mass spectrometry fingerprinting of the culture medium

Cortezzi¹,

Cabral²,

Trevisan³

et al. 2013

Reproduction

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This study has evaluated the performance of a multivariate statistical model to predict embryo implantation potential by processing data from the chemical fingerprinting of culture medium samples used for human embryo culture. The culture medium for 113 embryos from 55 patients undergoing ICSI was collected after embryo transfer. The samples were split into positive (nZ29) and negative (nZ84) implantation groups according their implantation outcomes (100% or 0% implantation). The samples were individually diluted and analyzed by electrospray ionization mass spectrometry (ESI-MS). The m/z ratios and relative abundances of the major ions in each spectrum were considered for partial least square discriminant analysis. Data were divided into two subsets (calibration and validation), and the models were evaluated and applied to the validation set. A total of 5987 ions were observed in the groups. The multivariate statistical model described more than 82% of the data variability. Samples of the positive group were correctly identified with 100% probability and negative samples with 70%. The culture media used for embryos that were positive or negative for successful implantation showed specific biochemical signatures that could be detected in a fast, simple, and noninvasive way by ESI-MS. To our knowledge, this is the first report that uses MS fingerprinting to predict human embryo implantation potential. This biochemical profile could help the selection of the most viable embryo, improving single-embryo transfer and thus eliminating the risk and undesirable outcomes of multiple pregnancies.

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Simplifying likelihood ratios

Cited by 771 publications

References 9 publications

Diagnostic Accuracy of 18F-FDG-PET in Patients with Testicular Cancer: a Meta-analysis

Diagnostic Accuracy of 18F-FDG-PET in Patients with Testicular Cancer: a Meta-analysis

Screening for the hyperkinetic disorder by using strength and difficulties questionnaire teacher-report (SDQ-TR) in Indonesia school-aged children

Prediction of embryo implantation potential by mass spectrometry fingerprinting of the culture medium

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