Diagnostic Accuracy of 18F-FDG-PET in Patients with Testicular Cancer: a Meta-analysis

Zhao, Jingyi; Ma, Xuelei; Li, Yanyan; Zhang, Binglan; Li, Minmin; Liu, Lei

doi:10.7314/apjcp.2014.15.8.3525

Cited by 19 publications

(9 citation statements)

References 46 publications

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“…It is well documented that CT alone cannot differentiate necrosis / fibrosis from viable tumor in residual disease post chemotherapy especially in lesions <3cm whereas its accuracy is 100% for masses >3 cm and 95% for masses <3 cm (Zhao et al, 2014). Other pitfalls include Large gonadal veins, duplication of the inferior vena cava, left-sided inferior vena cava, retro-aortic and circumaortic renal vessels and left ascending lumbar communicating veins.…”

Section: Introductionmentioning

confidence: 99%

Significance of 18F-FDG PET/CT in Characterization of Equivocal Lesions in High-Risk Testicular Carcinoma in Restaging Setting

Rasheed

Al-Kandari

Ghanem

et al. 2020

Asian Pac J Cancer Prev

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Positron emission tomography (PET)/computed tomography (CT) with 18 F fluorodeoxyglucose (18 F-FDG) has become pervasive as a tool for staging, restaging and follow-up of testicular cancer patients, especially in characterization of equivocal lesions on ultrasound (US), CT and MRI (Els et al., 2010). Testicular cancer represents between 1% and 1.5% of male cancers and 5% of urologic tumors, with 3 to 10 new cases occurring per 100,000 males per year (Albers et al., 2012). High risk factors include young age, prior family history, HIV, undescended testes, carcinoma In-situ and being white man. Over the last 30 years, the incidence of testicular cancer has increased (Manecksha et al., 2009). Bilateral presentation is low i.e.1% to 2% at diagnosis. There is a clear predominance (90%-95%) of germ cell tumors (GCT) despite of overall variation in presentation. Testicular cancers are classified

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Section: Introductionmentioning

confidence: 99%

Significance of 18F-FDG PET/CT in Characterization of Equivocal Lesions in High-Risk Testicular Carcinoma in Restaging Setting

Rasheed

Al-Kandari

Ghanem

et al. 2020

Asian Pac J Cancer Prev

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“…While the usage of 18 F-FDG PET-CT is controversial in testicular cancer diagnosis according to the guidelines of the European Association of Urology, there are many studies in the literature favoring its usage. A meta-analysis done by Zhao et al [ 8 ] examined a total of 16 studies, with a total number of patients up to 807 and 957 18 F-FDG PET exams. The meta-analysis showed sensitivity of 87% and specificity of 75%.…”

Section: Discussionmentioning

confidence: 99%

Review of the Literature: Organ of Giraldes Epididymal Appendage Presenting as a Painless Scrotal Mass in a 19-Year-Old Male—A Rare Urologic Entity

Dalati

Oliveira-e-Silva

Entezari

2015

Case Reports in Urology

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An incidental finding of a testicular mass in young male population is always a case of great concern for the patient and controversy for the physician. Differential diagnosis ranges from acute scrotum (notably testicular torsion), to acute inflammation and infection, all the way to testicular tumors. We present a case of an incidental finding of a painless testicular solid mass in a 19-year-old male patient, with an end pathological result of paradidymis (organ of Giraldes) following orchiectomy. To the best of our knowledge, this is the first case of its kind to be reported in the literature.

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“…A recent meta-analysis study by Zhao et al concluded that PET-CT may be an accurate noninvasive and useful diagnostic tool for patients with testicular cancer ( Figure 6). 38 A negative PET-CT result eliminates viability in large lesions and helps to avoid unnecessary surgery. In addition, PET-CT demonstrates good specificity, being a potentially useful tool if combined with other imaging methods.…”

Section: Lymph-node Metastases (N Stage)mentioning

confidence: 99%

“…67 PET-CT may also demonstrate false-positive (nonmalignant) hypermetabolic activity as a result of posttreatment inflammation. 38,68 For this reason, it might be prudent to perform PET-CT before chemotherapy or have an interval of no sooner than 4 weeks after chemotherapy. 69…”

Section: Restaging and Surveillancementioning

confidence: 99%

<p>Multimodality Radiological Pictorial Review of Testicular Carcinoma: From Initial Staging to Restaging</p>

Revels¹,

Wang²,

Gangadhar³

et al. 2020

RRU

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With an overall 5-year survival rate >95%, patients with testicular cancer have a great prognosis. Although initial diagnosis is based on clinical examination, imaging does play a significant role in the diagnosis and prognosis of testicular cancer, which are dependent on tumor burden and staging. Successful treatment requires appropriate disease assessment throughout a patient's treatment: evaluating treatment response, restaging, and monitoring for disease recurrence after treatment completion. Ultrasound is usually the initial screening modality for painless testicular masses, and computedtomography (CT) the most commonly used for staging and restaging. However, with regard to seminomas, positronemission tomography (PET) combined with CT is slowly taking priority. With regard to nonseminomatous germ-cell tumors, PET-CT has not proven to be completely effective, due to a high number of false-negative results. The purpose of this paper is to provide radiologists with a pictorial review of testicular carcinoma from initial staging through posttreatment follow-up.

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Diagnostic Accuracy of 18F-FDG-PET in Patients with Testicular Cancer: a Meta-analysis

Cited by 19 publications

References 46 publications

Significance of 18F-FDG PET/CT in Characterization of Equivocal Lesions in High-Risk Testicular Carcinoma in Restaging Setting

Significance of 18F-FDG PET/CT in Characterization of Equivocal Lesions in High-Risk Testicular Carcinoma in Restaging Setting

Review of the Literature: Organ of Giraldes Epididymal Appendage Presenting as a Painless Scrotal Mass in a 19-Year-Old Male—A Rare Urologic Entity

<p>Multimodality Radiological Pictorial Review of Testicular Carcinoma: From Initial Staging to Restaging</p>

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