Simplification of local therapy of psoriasis with 8-methoxypsoralen.

Abstract

Local 8-methoxypsoralen black-light treatment was carried out on sixty-two patients. For the first time, oil was employed as a preparation base in order to increase the transparency and so the effectiveness of irradiation. Also the need for a descaling pretreatment was avoided. In investigations still being carried out, 27.5% patients showed very good improvement, 48-4% good and 24-2% unsatisfactory results of treatment. In many cases, less than fifteen irradiation sessions were necessary for clinical healing. However, to obtain a uniform pigmentation, additional irradiation proved necessary.

Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis

“…Trioxsalen, on the other hand, is topically more effective than methoxsalen (Fischer & Alsins, 1976). Both of these psoralens have been used as alcoholic solutions and in creams with fairly good effect on psoriasis but vdth uneven tanning (Hofmann, Plewig & Braun-Falco, 1976;Schaefer et al, 1976;Tronnier & Heidbiichel, 1976;Fischer, 1977). Fischer and Alsins (1976) used trioxsalen baths and dysprosium lamps, giving both UVB and UVA, with good results and no apparent systemic side-effects.…”

Photochemotherapy (PUVA) of psoriasis using 3-carbethoxypsoralen, a non-carcinogenic compound in mice

“…This preliminary study on ten psoriatic patients clearly demonstrates that in some patients (four out often) good therapeutic results were obtained using the monofunctional furocoumarin, 3-CPs. It is interesting to compare the therapeutic efficacy of 3-CPs after local treatment with that obtained after local treatment with 8-MOP, as reported by four different teams (Walter & Voorhees, 1973;Weber, 1974;Schaefer et al, 1976;Petrozzi & Kligman, 1977) (see Table 3).…”

Variations of PUVA: Practical and Effective?

“…Topical PUVA therapy has been less popular in the treatment of psoriasis and other disorders because it can produce intense, long-lasting hyperpigmentation. 21,22 Few patients will thank you for replacing their red patches of psoriasis with dark brown patches that can persist for more than a year. An alternative to using methoxsalen lotion for topical therapy is to compound it into an ointment or cream base.…”