Variations of PUVA: Practical and Effective?

Morison, Warwick L.

doi:10.1001/archderm.134.10.1286

Cited by 8 publications

(2 citation statements)

References 24 publications

(19 reference statements)

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“…Previous studies have shown that TMP bath PUVA had no increased risk of squamous cell carcinoma or cutaneous malignant melanoma (6,13). However, the potential for severe phototoxicity has limited the use of TMP bath PUVA (14). In our latitudes (61aeN), sunlight is not a risk factor in winter for the use of TMP bath PUVA, but in summer we avoid using it.…”

mentioning

confidence: 91%

Cumulative UV radiation dose and outcome in clinical practice: effectiveness of trioxsalen bath PUVA with minimal UVA exposure

Snellman

Rantanen

Sundell

2000

Photoderm Photoimm Photomed

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mentioning

confidence: 91%

Cumulative UV radiation dose and outcome in clinical practice: effectiveness of trioxsalen bath PUVA with minimal UVA exposure

Snellman

Rantanen

Sundell

2000

Photoderm Photoimm Photomed

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“…199 Similar experiment performed with only a single light flash (10 or 20 J/cm 2 ) and 10 μmol of TMPyP was able to kill more than 4 log of B. atrophaeus. 200 These studies reinforce the application of PDI in military and national security for decontamination of anthrax spores. 198…”

Section: Photodynamic Inactivation (Pdi) Of Biological Warfare Agentsmentioning

confidence: 53%

Can biowarfare agents be defeated with light?

et al. 2013

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Biological warfare and bioterrorism is an unpleasant fact of 21st century life. Highly infectious and profoundly virulent diseases may be caused in combat personnel or in civilian populations by the appropriate dissemination of viruses, bacteria, spores, fungi, or toxins. Dissemination may be airborne, waterborne, or by contamination of food or surfaces. Countermeasures may be directed toward destroying or neutralizing the agents outside the body before infection has taken place, by destroying the agents once they have entered the body before the disease has fully developed, or by immunizing susceptible populations against the effects. A range of light-based technologies may have a role to play in biodefense countermeasures. Germicidal UV (UVC) is exceptionally active in destroying a wide range of viruses and microbial cells, and recent data suggests that UVC has high selectivity over host mammalian cells and tissues. Two UVA mediated approaches may also have roles to play; one where UVA is combined with titanium dioxide nanoparticles in a process called photocatalysis, and a second where UVA is combined with psoralens (PUVA) to produce “killed but metabolically active” microbial cells that may be particularly suitable for vaccines. Many microbial cells are surprisingly sensitive to blue light alone, and blue light can effectively destroy bacteria, fungi, and Bacillus spores and can treat wound infections. The combination of photosensitizing dyes such as porphyrins or phenothiaziniums and red light is called photodynamic therapy (PDT) or photoinactivation, and this approach cannot only kill bacteria, spores, and fungi, but also inactivate viruses and toxins. Many reports have highlighted the ability of PDT to treat infections and stimulate the host immune system. Finally pulsed (femtosecond) high power lasers have been used to inactivate pathogens with some degree of selectivity. We have pointed to some of the ways light-based technology may be used to defeat biological warfare in the future.

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Anti-microbial photodynamic therapy: useful in the future?

2006

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Previous chapters in this volume have focused on fundamental principles and clinical applications of PDT. This chapter will attempt to outline emerging areas of research to identify some new applications that may become useful in the future in clinical practise. The worldwide rise in antibiotic resistance has driven research to the development of novel anti-microbial strategies. Cutaneous diseases caused by MRSA are ideally suited to treatment by anti-microbial photodynamic therapy for eradicating localized infections and for modulating wound healing due to the ability to deliver photosensitizer and light with topical application. The use of photosensitizer and light as an anti-microbial agent against periodontal microbial biofilms should also represent an attractive method of eliminating oral bacteria. Suitable light sources, laser light and non-coherent light will be briefly covered. This chapter will focus on some aspects of anti-microbial photodynamic therapy that appear to be promising for dermatological indications and inactivation of pathogenic bacteria within the oral cavity.

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Variations of PUVA: Practical and Effective?

Cited by 8 publications

References 24 publications

Cumulative UV radiation dose and outcome in clinical practice: effectiveness of trioxsalen bath PUVA with minimal UVA exposure

Cumulative UV radiation dose and outcome in clinical practice: effectiveness of trioxsalen bath PUVA with minimal UVA exposure

Can biowarfare agents be defeated with light?

Anti-microbial photodynamic therapy: useful in the future?

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