Simple synthesis of novel copper metal–organic framework nanoparticles: biosensing and biological applications

Abstract

Novel copper metal organic framework nanoparticles Cu-MOF-NPs (C1) were prepared via two simple alternative methods and confirmed by analytical characterization using mass, IR, Raman, XRD spectrum, HR-TEM and TGA-DSC. Mass spectroscopy revealed the molecular ion peak at 647 m/z for the monomeric unit structure n[Cu(AIP)2(PIY)(H2O)2]·4H2O, the presence of which was further supported by mass fragmentation. The Raman spectrum revealed two separate peaks corresponding to D and G bands of carbon in the structure of C1. Moreover, TGA-DSC showed the presence of CuO. XRD data were typically consistent with Raman and TGA-DSC data. In addition, HR-TEM revealed that the morphology of the C1 nanoparticles is uniform with well-distributed elliptical/spherical particles with a size range from 7 to 19 nm. The spectrophotometric and biological activity studies based on Cu-MOF-NPs were analyzed. The results indicated that Cu-MOF-NPs (C1) were successfully used as biosensors for the assessment of the triiodothyronine hormone (T3). The calibration plot was achieved over the concentration range of 40.0-100.0 ng dl-1 T3 with limits of detection (LOD) and quantitation (LOQ) of 1.46 and 4.85 ng dl-1, respectively, and a correlation coefficient (r) of 0.973. Moreover, the Cu-MOF-NPs (C1) show more enhanced biological activity against various pathogens (five strains of bacteria: Gram positive and Gram negative) when compared to an antibacterial agent and the effectiveness of Cu-MOF-NPs increases with increasing particle dose. The interactions of MOF-NPs (C1) with the biological targets were studied.

A novel nano‐size lanthanum metal–organic framework based on 5‐amino‐isophthalic acid and phenylenediamine: Photoluminescence study and sensing applications

“…FT‐IR spectroscopy one of the important techniques which used in the characterization of the structures of the compounds . The most significant frequencies of La‐MOF which prepared via M1 and M2 in the IR spectra are shown in (Figure S1; supplementary material) and summarized in (Table ) both spectra were in adequate agreement.…”

“…The main objective of XRD is to determine the suggested structure of the metal complex and considered a further evidence about the structure. Previous reports mentioned that the transition metal complexes commonly are crystalline in nature and/or amorphous in nature with tetrahedral, octahedral or square planar geometry . (Figure S5; supplementary material) shows the XRD patterns of La‐MOF ( M1 and M2) which recorded between 2θ ranging from 3‐80 o .…”

“…The band observed at ~1470 cm −1 is due to ν(C–N) group. The absorption bands at ~668 and 603 cm −1 correspond to ν (La–O) covalent bonding and ν (La ← O) coordinate bonding, whereas the band observed at ~434 cm −1 is assigned to ν (La ← N) vibrations of the La‐MOF …”

“…(S6, Table I, and S7, Table II; supplementary material) introduce the summary of XRD data, the value of lattice parameter, Millar indices and inter‐planar distances and calculated crystallites size of La‐MOF. The crystallite size was found to be average 85 nm for the MOF …”

Promising photoluminescence optical approach for triiodothyronine hormone determination based on smart copper metal–organic framework nanoparticles

“…A variety of analytical methods, such as enzyme immunoassay (EIA), radioimmunological assays, rapid radioimmunoassay, colorimetric method, have been reported to detection of T3 hormone. Development and establish new methodologies and techniques concerning the screening and quantification of the hormones related to disrupting the endocrine system of humans and other biological targets recently has been a worldwide interest.…”