Simple fabrication of gelatin–polyvinyl alcohol bilayer hydrogel with wound dressing and nonadhesive duality

Barba, Bin Jeremiah D.; Oyama, Tomoko Gowa; Taguchi, Mitsumasa

doi:10.1002/pat.5442

Cited by 15 publications

(8 citation statements)

References 47 publications

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“…31 There have been interesting reports on the use of these materials for the preparation of wound dressings, too. [32][33][34] Due to their high hydrophilicity, these materials can maintain a moist wound environment, increase the rate of healing, and allow for easy removal after heating, as opposed to traditional gauze and cotton wool dressings. However, in their hydrated (swollen) state, they exhibit very low mechanical properties, which is undesirable for use as wound dressing membranes.…”

Section: Resultsmentioning

confidence: 99%

Polyhexamethylene guanidine hydrochloride‐functionalized wound dressings: Physical, mechanical and biological evaluations

Babaahmadi

Yeganeh

2023

Polymers for Advanced Techs

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The objective of the present study is fabrication of wound dressing membranes with effective antibacterial activity, good biocompatibility with fibroblast cells, appropriate mechanical properties in both dry and wet states to potentially provide physical protection to wounds at different stages of healing, and the ability to maintain an optimum moist environment over the wounded area. To achieve this, a new silane functional polyhexamethylene guanidine hydrochloride was synthesized and utilized as a crosslinker for a polymeric matrix consisting of poly(vinyl alcohol) and gelatin. Thin monolayer films of the resulting polymeric networks were characterized and subjected to different physical and biological assays. The tensile test results indicated that the prepared dressing membranes exhibit good tensile strength in both dry (44 MPa) and hydrated (700 KPa) states. The fluid handling capacity of the dressings was found to be in the range of 2.23 to 2.29 g 10−1 m−2 day−1, which is appropriate for treating wounds with “light” to “moderate” exudate levels. The MTT assay showed excellent biocompatibility, evidenced by high fibroblast cells viability cultured directly over dressings (over 70%) or cultured in media containing the leachates extracted from the dressings (over 90%). Moreover, the dressings exhibited potent antibacterial activity against Staphylococcus aureus (87% killing) and Escherichia coli (99% killing) bacterial strains.

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Section: Resultsmentioning

confidence: 99%

Polyhexamethylene guanidine hydrochloride‐functionalized wound dressings: Physical, mechanical and biological evaluations

Babaahmadi

Yeganeh

2023

Polymers for Advanced Techs

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“…Protein hydrogels have been prepared as scaffolding materials for the three-dimensional culture of cells [14] and contrast agents for magnetic resonance imaging diagnostics [15]. These hydrogels have also been used to produce cell sheets on which cells form three-dimensional structures by themselves [16] and materials for preventing organ adhesion after abdominal surgery [17].…”

Section: Methodsmentioning

confidence: 99%

Development of Environmentally Friendly Cellulose Derivative-Based Hydrogels for Contact Lenses Using a Radiation Crosslinking Technique

Hiroki

Taguchi

2021

Applied Sciences

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Although they have potential environmental pollution issues, soft contact lenses are value-added biodevices for medical use. Thus, it is important to reconsider starting materials and production methods to achieve sustainable development. In this study, hydrogels composed of hydroxypropyl cellulose (HPC) as an environmentally friendly material were produced by radiation and investigated for use in disposable soft contact lenses. HPC-based hydrogels with good mechanical properties and transparency were prepared by irradiation of electron beams on highly concentrated aqueous solutions containing HPC, polyethylene glycol #1000 dimethacrylate (23G), and 2-hydroxyethyl methacrylate (HEMA). The addition of 23G to HPC aqueous solutions resulted in an increase in the gel fraction as well as improved mechanical properties, such as tensile strength and elongation at break. The tensile strength and the elongation at break of HPC/HEMA/23G hydrogel obtained by the further addition of HEMA with HPC/23G aqueous solutions exhibited 0.2 MPa and 124%, which were approximately 2.0 and 1.8 times larger than these of the pure HPC hydrogel, respectively. The evaluation of the properties of the HPC/HEMA/23G hydrogel demonstrated its potential as a soft contact material with improved mechanical properties.

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“…Skin lesions of a diverse nature of origin increase the risk of consequences for the body, even after years. In order to avoid the appearance of adhesions after surgery, a bilayer hydrogel dressing was developed consisting of gelatin and polyvinyl alcohol (PVA) with simultaneous non-reagent radiation-induced crosslinking by γ-rays and having both dressing and anti-adhesion properties [ 91 ].…”

Section: Biomedical Application Of Bilayer Hydrogelsmentioning

confidence: 99%

Bilayer Hydrogels for Wound Dressing and Tissue Engineering

2022

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A large number of different skin diseases such as hits, acute, and chronic wounds dictate the search for alternative and effective treatment options. The wound healing process requires a complex approach, the key step of which is the choice of a dressing with controlled properties. Hydrogel-based scaffolds can serve as a unique class of wound dressings. Presented on the commercial market, hydrogel wound dressings are not found among proposals for specific cases and have a number of disadvantages—toxicity, allergenicity, and mechanical instability. Bilayer dressings are attracting great attention, which can be combined with multifunctional properties, high criteria for an ideal wound dressing (antimicrobial properties, adhesion and hemostasis, anti-inflammatory and antioxidant effects), drug delivery, self-healing, stimulus manifestation, and conductivity, depending on the preparation and purpose. In addition, advances in stem cell biology and biomaterials have enabled the design of hydrogel materials for skin tissue engineering. To improve the heterogeneity of the cell environment, it is possible to use two-layer functional gradient hydrogels. This review summarizes the methods and application advantages of bilayer dressings in wound treatment and skin tissue regeneration. Bilayered hydrogels based on natural as well as synthetic polymers are presented. The results of the in vitro and in vivo experiments and drug release are also discussed.

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Simple fabrication of gelatin–polyvinyl alcohol bilayer hydrogel with wound dressing and nonadhesive duality

Cited by 15 publications

References 47 publications

Polyhexamethylene guanidine hydrochloride‐functionalized wound dressings: Physical, mechanical and biological evaluations

Polyhexamethylene guanidine hydrochloride‐functionalized wound dressings: Physical, mechanical and biological evaluations

Development of Environmentally Friendly Cellulose Derivative-Based Hydrogels for Contact Lenses Using a Radiation Crosslinking Technique

Bilayer Hydrogels for Wound Dressing and Tissue Engineering

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