In this paper, a compact, highly integrated multiplexing filtering antenna operating at 4.7/5.2/6.0/6.6 GHz is proposed for the first time. Different from traditional antennas, the proposed antenna has one shared radiator but four ports working in different frequency bands and thus, it can simultaneously support four different transmission channels. The proposed multiplexing antenna is composed of a patch with a U-shaped slot, two substrate integrated waveguide (SIW) cavities, and four resonator-based frequency-selective paths. The resonator-based paths can not only enhance the inter-channel isolations but also improve the impedance bandwidth. The design principles and the methods of controlling the four operating bands are studied. Measurement results agree reasonably well with the simulations, showing four channels from 4.5 to 4.8 GHz, 5.1 to 5.3 GHz, 5.85 to 6.3 GHz, and 6.4 to 6.6 GHz, respectively. The antenna also exhibits a high isolation of over 25 dB between the channels. In addition, the proposed antenna has a consistent broadside radiation pattern and polarization in the four bands, manifesting the proposed multiplexing filtering antenna can be a promising candidate for multi-service wireless communication systems.