Simple and Sensitive Paper-Based Device Coupling Electrochemical Sample Pretreatment and Colorimetric Detection

Silva, Thalita G.; Araújo, Wanderley Pereira de; Muñoz, Rodrigo A.A.; Richter, Eduardo M.; Santana, Mário H.P.; Coltro, Wendell K. T.; Paixão, Thiago R.L.C.

doi:10.1021/acs.analchem.6b00072

Cited by 71 publications

(51 citation statements)

References 28 publications

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“…(2018) solved this problem by applying a cathodic pretreatment (−0.8 V for 360 s before each SWV scan) on unmodified graphite disposable electrodes, resulting in a separation of the peaks for the determination of cocaine in the presence of LEV . A similar approach was demonstrated to eliminate the interference of the most common cutting agents on the colorimetric detection of cocaine . Florea et al .…”

Section: Introductionmentioning

confidence: 99%

Simple Strategy for Selective Determination of Levamisole in Seized Cocaine and Pharmaceutical Samples Using Disposable Screen‐printed Electrodes

et al. 2018

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Levamisole is the most common adulterant found in cocaine samples and its electrochemical determination in cocaine seized samples is a challenge due to peak overlapping with cocaine. Herein, we propose a deconvolution procedure for levamisole determination in seized cocaine samples using screen‐printed carbon electrodes (SPE). Square‐wave voltammetry in 0.04 mol L−1 Britton Robinson buffered solution (pH 8.0) was selected in combination with optimized SWV parameters (f=8 s−1, a=10 mV and ΔEs=1 mV) to result in the best peak resolution to apply the deconvolution procedure. Deconvoluted responses of levamisole in the presence of cocaine were similar to untreated signals of standard levamisole solutions in absence of cocaine. A linear response was obtained in the range of 20–100 μmol L−1 (r=0.995). The results obtained for the analysis of a seized cocaine sample was statistically similar to that obtained by gas chromatography. Other adulterants found in cocaine street samples (paracetamol, glucose, phenacetin, caffeine, boric acid and lidocaine) did not affect the treated of voltammetric responses of levamisole. A pharmaceutical sample containing levamisole was also analyzed on SPEs and a recovery of 93±2 % was obtained (no deconvolution required for this sample), showing great applicability of SPEs for forensic and pharmaceutical analyses.

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Section: Introductionmentioning

confidence: 99%

Simple Strategy for Selective Determination of Levamisole in Seized Cocaine and Pharmaceutical Samples Using Disposable Screen‐printed Electrodes

et al. 2018

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“…Zuschriften microfluidic PA Ds [6,9] for in-field analysis.The low fabrication cost makes this method ag ood replacement to commercial screen-printed carbon electrodes,w hich incur a3 00-fold higher cost.…”

Section: Angewandte Chemiementioning

confidence: 99%

“…Other fabrication methods involve the use of graphite leads or direct pencil drawing, wire or fiber attachment, [8] or combining commercial electrodes on paper. [9] However,these procedures are usually performed manually and lack reproducibility or result in sluggish heterogeneous electron transfer to some electroactive compounds.Sputtering of electrodes is an alternative,b ut this process is expensive and limited to laboratory settings. [10] Thep yrolysis of organic compounds generates carbon materials that vary from completely amorphous to wellordered graphite-like structures depending on the temperature.…”

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confidence: 99%

Single‐Step Reagentless Laser Scribing Fabrication of Electrochemical Paper‐Based Analytical Devices

et al. 2017

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Asingle-step laser scribing process is used to pattern nanostructured electrodes on paper-based devices.T he facile and low-cost technique eliminates the need for chemical reagents or controlled conditions.T his process involves the use of aC O 2 laser to pyrolyze the surface of the paperboard, producing ac onductive porous non-graphitizing carbon material composed of graphene sheets and composites with aluminosilicate nanoparticles.The new electrode material was extensively characterized,and it exhibits high conductivity and an enhanced active/geometric area ratio;i ti st hus well-suited for electrochemical purposes.A saproof-of-concept, the devices were successfully employed for different analytical applications in the clinical, pharmaceutical, food, and forensic fields.T he scalable and green fabrication method associated with the features of the new material is highly promising for the development of portable electrochemical devices.

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“…It is widely used in the injectable form as an injection with antibiotics and can relieve pain associated with medical procedures used in gynaecology, dentistry, surgery, and anaesthesia block therapy. It can however, also be used as a stimulating drug (Guan et al, 2016;Silva et al, 2016). PRC is less toxic and less expensive than both cocaine and tetracaine.…”

Section: Introductionmentioning

confidence: 99%

Development of an immunochromatographic test strip for the detection of procaine in milk

Hao

Suryoprabowo

Song

et al. 2018

Food and Agricultural Immunology

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Procaine (PRC) is a local anaesthetic used in the treatment of several disease related to ageing, asthma, and arthritis. In this study, we describe a rapid, sensitive, simple, and accurate method for the determination of PRC in milk, using an immunochromatographic test strip. For the immunochromatographic test, antigen (PRCbovine serum albumin) and goat anti-mouse IgG were drawn onto a nitrocellulose membrane representing the control line and test line. The test was developed with a sensitive monoclonal antibody specific for PRC, generated by immunizing BALB/c mice with a well-characterized PRC-Keyhole limpet hemocyanin conjugate, produced in our laboratory. Under optimized conditions, the semiquantitative test strip was able to detect PRC at concentrations down to 1 ng/mL in both 0.01 M phosphate buffer saline (pH 7.4) and milk samples. All results were obtained within 5 min. Our data indicate that the immunochromatographic assay is capable of sensitive, rapid, and specific on-site screening of PRC.

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Simple and Sensitive Paper-Based Device Coupling Electrochemical Sample Pretreatment and Colorimetric Detection

Cited by 71 publications

References 28 publications

Simple Strategy for Selective Determination of Levamisole in Seized Cocaine and Pharmaceutical Samples Using Disposable Screen‐printed Electrodes

Simple Strategy for Selective Determination of Levamisole in Seized Cocaine and Pharmaceutical Samples Using Disposable Screen‐printed Electrodes

Single‐Step Reagentless Laser Scribing Fabrication of Electrochemical Paper‐Based Analytical Devices

Development of an immunochromatographic test strip for the detection of procaine in milk

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