Simple and cost-effective polycondensation routes to antimicrobial consumer products

Zhang, Musan; Teo, Jye Jyn; Liu, Shaoqiong; Liang, Zhen; Ding, Xin; Ono, Robert J.; Breyta, Gregory; Engler, Amanda C.; Coady, Daniel J.; Garcia, Jeanette; Nelson, Alshakim; Yang, Yi Yan; Hedrick, James L.

doi:10.1039/c6py00592f

Cited by 12 publications

(10 citation statements)

References 40 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymers containing bile acids in the main chain have been prepared using step-growth polymerization via incorporating a variety of linkers, such as esters, anhydrides, triazoles, β-amino esters and sulfide [ [34] , [35] , [36] , [37] , [38] ]. Polycondensations are useful to prepare highly efficacious and inexpensive antimicrobial polymers for numerous applications [ 39 ]. A unique class of polyelectrolytes known as ammonium polyionenes can be prepared by step-growth polymerizations to have cations in the main chain at regular and specific sites [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

Ganewatta

Rahman

Mercado

et al. 2018

Bioactive Materials

View full text Add to dashboard Cite

Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interestingly, by choosing appropriate monomers, these cationic polymers can form core-shell micelles. These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species. It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities. Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.

show abstract

Section: Introductionmentioning

confidence: 99%

Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

Ganewatta

Rahman

Mercado

et al. 2018

Bioactive Materials

View full text Add to dashboard Cite

show abstract

“…In comparison with guanidine units, primary amines showed higher antimicrobial potency after being linked with poly(methacrylamide), however the guanidine units showed higher antimicrobial activity after being conjugated to poly(norobornene) and polyacrylate; and quaternary amines and guanidine showed similar antimicrobial activity after being linked to some condensation polymers . New antimicrobial units were also reported.…”

Section: Introductionmentioning

confidence: 92%

Developments in antimicrobial polymers

Ren

Cheng

Wang

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

View full text Add to dashboard Cite

Effective antimicrobial polymers have been attracting more interests because of the low propensity to cause drug‐resistant microorganisms. The recent progresses in antimicrobial polymers are updated according to the action approaches, that is, antimicrobial polymers with free mobility or fixed on surfaces, respectively. Free antimicrobial polymers kill pathogens majorly via electrostatic interaction followed by disruption of the cell membranes; strong antimicrobial activity of primary/secondary amines, new chemical units, and peptides without facial amphiphilicity are highlighted; and the dependences on amphiphilicity, topology, and self‐assembly profiles are summarized. Antimicrobial polymers fixed on surfaces kill pathogens via interaction with the cell membranes of pathogens via electrostatic or hydrophobic interaction; approaches to antimicrobial surfaces based on covalently grafting, anchoring, and bulk‐mixing of polymers are summarized; and new designs of sustainable antimicrobial surfaces and hydrogels are highlighted. Deep biology understanding and development strategies of materials are suggested for the future. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 632–639

show abstract

“…2,[25][26][27] In this study, reactive quaternary ammonium monomer were incorporated into the foam formulation to be able to endow the material with antimicrobial properties. The antimicrobial tests were performed with E. coli and S. aureus to have representatives from Gram-negative and Gram-positive bacteria.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

Antimicrobial polyurethane foams having cationic ammonium groups

Udabe

Işık

Sardón

et al. 2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

Polyurethane foams were prepared by using functional quaternary ammonium monomers to endow the porous materials with antimicrobial properties. For this purpose, tri‐ and tetra‐hydroxyl functional quaternary ammonium compounds were synthesized and used as a triol and tetraol monomer in a polyurethane foam formulation. By this method, the cationic ammonium group is chemically incorporated into the polyurethane backbone. Polyurethane foams containing different amounts of the quaternary ammonium functional group were prepared and characterized by means of Fourier transform infrared spectroscopy, carbon solid‐state nuclear magnetic resonance, and scanning electron microscopy. The antimicrobial properties of the cationic polyurethane foams were evaluated toward Escherichia coli and Staphylococcus aureus Gram‐negative and Gram‐positive bacteria, respectively. Polyurethane foams containing more than 20% of quaternary ammonium component display high antimicrobial activity and can be used for several applications requiring antimicrobial properties. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45473.

show abstract

Simple and cost-effective polycondensation routes to antimicrobial consumer products

Abstract: Cost-effective macromolecular antimicrobials were synthesized to explore a variety of chemical functional groups that target antimicrobial performance and reduce cytotoxicity.

Cited by 12 publications

References 40 publications

Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

Developments in antimicrobial polymers

Antimicrobial polyurethane foams having cationic ammonium groups

Contact Info

Product

Resources

About