Similarity between Some Biological Systems, Organotropism and Metastatic Process: Active Role Played By Secondary Organ?

Abstract

According to literature, about 90% of death from cancer is related to metastasis. Metastatic process present many similarity to some other biological processes. Once we have examined some relevant biomedical literature, by understanding the real causes of metastasis, it would become much more possible to introduce new therapeutic strategies to delay or in some cases even to stop this kind of killer process. Breast cancer, as an example, produces metastasis to different organs, which seems to be related to the subtype. We believe that a deep understanding of the roles of breast cancer cells and their interactions with the liver microenvironment in early breast cancer metastasis could be a crucial factor for the design and development of effective BCLM breast cancer liver metastases therapeutic strategies and to better understand the general process. Let's suppose the secondary organ or organs can be considered as incubator/s for the primary metastatic cells. What kind of consequences we can have in therapy fi eld if there is an active regulating role in determining the location of secondary cancers?Let's observe the role played by liver, bone marrow, CNS central nervous system, lungs, lymphocytes and other secondary locations/organs a little bit closer or maybe from a different angle let's suppose we try to come up with just a hypothesis. Just let's take this as a possibility, and we take the thread to see where it takes us.

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“…Luisetto, et al [19] write: "According all this scientific literature is possible to conclude that: In those biologic systems we have given as models, many of biological processes go through a first phase to a final phase which in some cases transitions to a more advantageous, or a sort of parasitism-simbiontic process with advantages to all or what we call it win -win mutual benefits situation (organism and parassites). Once we examine all these models, who would extrapolate a similar model for metastasis which we call it the "seed and soil" hypothesis: we have different role played by dissemination process of metastatic cells and the secondary organ role.…”

Endogenus Toxicology: Modern Physio- Pathological Aspects and Relationship with New Therapeutic Strategies. An Integrative Discipline Incorporating Concepts from Different Research Discipline Like Biochemistry, Pharmacology and Toxicology

“…Luisetto, et al [19] write: "According all this scientific literature is possible to conclude that: In those biologic Luisetto systems we have given as models, many of biological processes go through a first phase to a final phase which in some cases transitions to a more advantageous, or a sort of parasitism-simbiontic process with advantages to all or what we call it win -win mutual benefits situation (organism and parassites). Once we examine all these models, who would extrapolate a similar model for metastasis which we call it the "seed and soil" hypothesis: we have different role played by dissemination process of metastatic cells and the secondary organ role.…”