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Abstract

Many pathologic diseases can be considered as related to an Endogenous toxicological movens and in time dependent way. In this work starting from the analisys of relevant literature involved with different disease and related to the endogenous local micro-environment some global conclusion useful as new tools for innovative pharmacological strategies will be submitted to the researcher. Physiology, pathology concept linked to the endogenous toxicological local micro-environment as new research instruments. The same carcinogenesis process can be related also to endogenous agents that may have a major contribution in spontaneously process. (reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins).