Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore

Morciano, Giampaolo; Pedriali, Gaia; Mikus, Elisa; Cimaglia, Paolo; Calvi, Simone; Pavasini, Rita; Albertini, Alberto; Ferrari, Roberto; Wieckowski, Mariusz R.; Giorgi, Carlotta; Campo, Gianluca; Pinton, Paolo

doi:10.1111/eci.13764

Cited by 3 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, in STEMI patients a mutation that aggravates mPTP-mediated IRI when expressed in human cardiomyocytes has been found ( Morciano et al, 2021b ). Besides mutations, a significative and positive correlation between the mPTP opening measured in fibroblasts from patients and IRI degree, evaluated by the cardiac magnetic resonance imaging, was found ( Morciano et al, 2022 ).…”

Section: Mitochondrial Remodeling and State Of Health In I/r Conditionmentioning

confidence: 99%

Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury

Pedriali

Ramaccini

Bouhamida

et al. 2022

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

Cardiovascular disease is the most common cause of death worldwide and in particular, ischemic heart disease holds the most considerable position. Even if it has been deeply studied, myocardial ischemia-reperfusion injury (IRI) is still a side-effect of the clinical treatment for several heart diseases: ischemia process itself leads to temporary damage to heart tissue and obviously the recovery of blood flow is promptly required even if it worsens the ischemic injury. There is no doubt that mitochondria play a key role in pathogenesis of IRI: dysfunctions of these important organelles alter cell homeostasis and survival. It has been demonstrated that during IRI the system of mitochondrial quality control undergoes alterations with the disruption of the complex balance between the processes of mitochondrial fusion, fission, biogenesis and mitophagy. The fundamental role of mitochondria is carried out thanks to the finely regulated connection to other organelles such as plasma membrane, endoplasmic reticulum and nucleus, therefore impairments of these inter-organelle communications exacerbate IRI. This review pointed to enhance the importance of the mitochondrial network in the pathogenesis of IRI with the aim to focus on potential mitochondria-targeting therapies as new approach to control heart tissue damage after ischemia and reperfusion process.

show abstract

Section: Mitochondrial Remodeling and State Of Health In I/r Conditionmentioning

confidence: 99%

Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury

Pedriali

Ramaccini

Bouhamida

et al. 2022

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

show abstract

Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore

Morciano

Pedriali

Mikus

et al. 2022

Eur J Clin Investigation

Self Cite

View full text Add to dashboard Cite

Modulation of mitochondrial permeability transition pores in reperfusion injury: Mechanisms and therapeutic approaches

Morciano,

Pinton

2024

Eur J Clin Investigation

View full text Add to dashboard Cite

Ischemia/reperfusion injury is attracting continuous interest in science for two reasons: because it affects several clinical conditions and because it has been identified, albeit in broad terms, the molecular entity becoming activated by the reperfusion damage paradoxes. Indeed, calcium, oxygen‐dependent oxidative stress and pH would activate conformational changes in the mitochondrial cristae embedded F1/FO ATP synthase, allowing the formation of pores in the inner mitochondrial membrane thus increasing its permeability. This is a key determinant for mitochondrial stress, cell death and tissue dysfunction. Targeting each of these factors has never contributed to improved clinical outcome of the patients affected by reperfusion damage; now, the focus on the PTP opening could represent the closest target to solve this pathway made by extensive cell death when the tissues become revascularized. In this review, we summarized last knowledge about the structure, the modulation and the therapeutic targeting of the PTP, focusing on ATP synthase and cardiac ischemia/reperfusion.

show abstract

Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore

Cited by 3 publications

References 18 publications

Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury

Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury

Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore

Modulation of mitochondrial permeability transition pores in reperfusion injury: Mechanisms and therapeutic approaches

Contact Info

Product

Resources

About