Modulation of mitochondrial permeability transition pores in reperfusion injury: Mechanisms and therapeutic approaches
Giampaolo Morciano,
Paolo Pinton
Abstract:Ischemia/reperfusion injury is attracting continuous interest in science for two reasons: because it affects several clinical conditions and because it has been identified, albeit in broad terms, the molecular entity becoming activated by the reperfusion damage paradoxes. Indeed, calcium, oxygen‐dependent oxidative stress and pH would activate conformational changes in the mitochondrial cristae embedded F1/FO ATP synthase, allowing the formation of pores in the inner mitochondrial membrane thus increasing its … Show more
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