Silymarin Protects Against Acute Ethanol‐Induced Hepatotoxicity in Mice

Abstract

Background-Accumulated evidence has demonstrated that both oxidative stress and abnormal cytokine production, especially tumor necrosis factor-α (TNF), play important etiological roles in the pathogenesis of alcoholic liver disease (ALD). Agents that have both antioxidant and antiinflammation properties, particularly anti-TNF production, represent promising therapeutic interventions for ALD. We investigated the effects and the possible mechanism(s) of silymarin on liver injury induced by acute ethanol (EtOH) administration.

Protective Effects of Moringa oleifera extract on Isoniazid and Rifampicin Induced Hepatotoxicity in Rats: Involvment of Adiponectin and Tumor Necrosis Factor-α

“…The hepatoprotective effect of Moringa oleifera against liver inflammation is attained by its reduction of the liver content of TNF-α and this was agreed with Mahajan et al [58]. The same action also happened with administration of silymarin that decreased TNF-α liver content, these results agree with Song et al [59].…”

Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat

“…The anti-inflammatory effects of silymarin are also based on multiple activities including mast cell stabilization, inhibition of neutrophil migration, Kupffer cell inhibition, inhibition of leukotrienes, and prostaglandin formation (Song et al 2006). In addition, it is likely that the hepatoprotective effect of silymarin is related to prevention of hypoxia in hepatic fibrogenesis (Song et al 2006).…”

“…In addition, it is likely that the hepatoprotective effect of silymarin is related to prevention of hypoxia in hepatic fibrogenesis (Song et al 2006). Recent study supported the use of silymarin as hepatoprotective remedy; it has been used for the treatment of numerous liver disorders characterized by functional impairment or degenerative necrosis.…”

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

“…Numerous other antioxidants show efficacy in treating fatty liver diseases and include Nacetylcysteine [166], zinc [167,168], silymarin [169], and ursodeoxycholic acid [170], just to name a few. Please refer to the following excellent review articles for additional information on antioxidant therapy for treatment of fatty liver diseases from multiple causes [144,[171][172][173][174].…”