Silymarin and Nigella sativa extract ameliorate paracetamol induced oxidative stress and renal dysfunction in male mice

Hamza, Reham Z.; AL-Harbi, Mohammad S.

doi:10.1016/s2222-1808(15)60882-9

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…In our results APAP caused significant decreases in catalase and reduced glutathione activities while caused significant increase in MDA activity, that clear manifestation of excessive formation of free radicals and activation of lipid peroxidation system resulting in tissue damage. These results in harmony with those of [33] who reported that administration of APAP induced a significant decrease in CAT activity and elicited a significant increase in MDA level. Also [34] demonstrated that there were decreases in levels of GSH and catalase activities, and increases in serum marker enzymes and lipid peroxidation level in APAP treated rats which may be due to hepatocellular damage.…”

Section: Anti-oxidantssupporting

confidence: 91%

Moringa Oleifera Seed Oil Modulates Effects of Acetaminophen on Some Biochemical Parameters in Male Rats

El-Shafey

Seliem

El-Daly

et al. 2018

Benha Journal of Applied Sciences

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Moringa oleifera (MO) is a common herbal plant used as human food and for medicinal purposes worldwide. Acetaminophen (APAP) is used as antipyretic and analgesic drug, while causing hepatotoxicity at over dose.The present study is aimed to evaluate the hepatoprotective effect of MO seed oil extract against the biochemical changes induced by APAP in male adult albino rats. Thirty five male albino rats were used in this study, divided randomly into five groups (7 rats in each). The 1 st control group; untreated animals, the 2 nd saline group received single dose of normal physiological saline, the 3 rd group treated with single dose of APAP (500 mg / kg b.wt) for hepatotoxicity induction, the 4 th group treated with MO seed oil extract (0.3 ml/rat) daily for 30 days and the 5 th group treated with a single dose of APAP and with MO seed oil extract daily for 30 days to evaluate its protective effects. Blood samples were collected for serum preparation and biochemical analysis. Results showed that APAP induced a significant increase in blood glucose level which is against to the effect produced by the treatment with MO seed oil. All measured kidney function parameters increased significantly after treatment with APAP. Oppositely, animals treated with MO seed oil after APAP showed depression in kidney function parameters. APAP treated group showed significant decreases in catalase (CAT) activity and reduced glutathione (GSH) level while showed a significant increase in malondialdehyde (MDA) activity. Rats treated with MO seed oil showed significant increases in catalase and GSH activities while caused a significant decrease in MDA concentration. Treatment with MO seed oil after APAP induced significant decrease and increase in GSH and MDA levels respectively compared to those of control group. The present study concluded that the MO seed oil extract has ameliorative effects against some biochemical disturbances induced by acetaminophen possibly through its anti-oxidative properties.

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Section: Anti-oxidantssupporting

confidence: 91%

Moringa Oleifera Seed Oil Modulates Effects of Acetaminophen on Some Biochemical Parameters in Male Rats

El-Shafey

Seliem

El-Daly

et al. 2018

Benha Journal of Applied Sciences

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“…No necrotic changes could be seen. Similar damage for liver tissues by APAP has been recorded [25][26][27][28]. SeNPs showed also ameliorative effect, histologically, on hepatotoxicity induced by drugs or parasites in several investigations [14,29].…”

Section: Resultssupporting

confidence: 56%

Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice

AL-Harbi¹,

Amer²

2017

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Selenium nanoparticles (SeNPs) have been widely used as anti-inflammatory and anti-toxic agent. The present study used Bacillus tequilensis for biosynthesizing SeNPs from sodium selenite (Na 2 SeO 3 ) and investigated its ameliorative effects on acetaminophen (APAP) hepatotoxicity in male mice. The results indicated that Alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) significantly elevated in mice treated with APAP, while other liver markers (total proteins and albumin) did not change. SeNPs either alone or in combination with APAP showed ameliorative effects on liver enzymes to some extents where their activities decreased to be insignificant with those of normal group. A slight variation was shown in total antioxidant capacity (TAC). Histopathologically, the hepatocytes of the mice treated with APAP showed cloudy swelling and vacuolar degeneration, while those treated with SeNPs or both SeNPs and APAP appeared more or less histologically normal. In conclusion, SeNPs can be used to improve or replace today's therapies of APAP hepatotoxicity.

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“…It has been confirmed that superoxide anion and hydrogen peroxide (H 2 O 2 ) are formed during metabolic paracetamol activation in the CYP 450 system and from the mitochondria during toxicity with paracetamol (Hamza and AL-Harbi, 2015).…”

Section: Discussionmentioning

confidence: 98%

Experimental Study of the Possible Protective Effect of Alpha-Lipoic Acid on Paracetamol induced Oxidative Stress and Hepatic Toxicity in albino rats

Allam

Kasem

Mahmoud

et al. 2021

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background: Paracetamol, is the most widely used over-the-counter analgesic and antipyretic medication in the world, which has minimal adverse effects at therapeutic dosages. But in high doses causes hepatic damage and oxidative stress. Objectives: The current study was designed to investigate paracetamol toxic effects upon the liver and oxidative stress after repeated oral dose and evaluate possible protective effect of alpha lipoic acid when co-administered with and after paracetamol. Methods: forty eight white albino rats were divided equally into four groups. Each group was subdivided into two sub groups A & B. Group I received gum acacia suspension. Group II received Alpha lipoic acid (50mg/kg) orally. Group III received paracetamol (1 gm/ kg orally) for 4 weeks. Group IV received paracetamol and alpha lipoic acid at the same doses. Sub groups A were euthanized after 4 weeks, while sub groups B were euthanized after 8 weeks. Blood was collected for evaluation of liver functions and oxidative stress marker. The livers were preserved for histopathological examinations. Results: The study proved that repeated administration of paracetamol induced disturbed liver functions and oxidative stress. But this toxic effects decline markedly when alpha lipoic acid (ALA) was coadministered with paracetamol. And more improvement occurs when ALA was administered for another 4 weeks after stoppage of paracetamol. Conclusions: The present study concluded that repeated paracetamol administration has hepatotoxic and oxidative stress effect and alpha lipoic acid has a protective effect against such harmful effects especially when ALA was administered for another 4 weeks after stoppage of paracetamol.

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Silymarin and Nigella sativa extract ameliorate paracetamol induced oxidative stress and renal dysfunction in male mice

Cited by 7 publications

References 26 publications

Moringa Oleifera Seed Oil Modulates Effects of Acetaminophen on Some Biochemical Parameters in Male Rats

Moringa Oleifera Seed Oil Modulates Effects of Acetaminophen on Some Biochemical Parameters in Male Rats

Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice

Experimental Study of the Possible Protective Effect of Alpha-Lipoic Acid on Paracetamol induced Oxidative Stress and Hepatic Toxicity in albino rats

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