2015
DOI: 10.1016/s2222-1808(15)60882-9
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Silymarin and Nigella sativa extract ameliorate paracetamol induced oxidative stress and renal dysfunction in male mice

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Cited by 7 publications
(6 citation statements)
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“…In our results APAP caused significant decreases in catalase and reduced glutathione activities while caused significant increase in MDA activity, that clear manifestation of excessive formation of free radicals and activation of lipid peroxidation system resulting in tissue damage. These results in harmony with those of [33] who reported that administration of APAP induced a significant decrease in CAT activity and elicited a significant increase in MDA level. Also [34] demonstrated that there were decreases in levels of GSH and catalase activities, and increases in serum marker enzymes and lipid peroxidation level in APAP treated rats which may be due to hepatocellular damage.…”
Section: Anti-oxidantssupporting
confidence: 91%
“…In our results APAP caused significant decreases in catalase and reduced glutathione activities while caused significant increase in MDA activity, that clear manifestation of excessive formation of free radicals and activation of lipid peroxidation system resulting in tissue damage. These results in harmony with those of [33] who reported that administration of APAP induced a significant decrease in CAT activity and elicited a significant increase in MDA level. Also [34] demonstrated that there were decreases in levels of GSH and catalase activities, and increases in serum marker enzymes and lipid peroxidation level in APAP treated rats which may be due to hepatocellular damage.…”
Section: Anti-oxidantssupporting
confidence: 91%
“…No necrotic changes could be seen. Similar damage for liver tissues by APAP has been recorded [25][26][27][28]. SeNPs showed also ameliorative effect, histologically, on hepatotoxicity induced by drugs or parasites in several investigations [14,29].…”
Section: Resultssupporting
confidence: 56%
“…It has been confirmed that superoxide anion and hydrogen peroxide (H 2 O 2 ) are formed during metabolic paracetamol activation in the CYP 450 system and from the mitochondria during toxicity with paracetamol (Hamza and AL-Harbi, 2015).…”
Section: Discussionmentioning
confidence: 98%