Silver nanoparticles biosynthesized by Anabaena flos-aquae enhance the apoptosis in breast cancer cell line

Ebrahimzadeh, Z; Salehzadeh, Ali; Naeemi, Akram Sadat; Jalali, Amir

doi:10.1007/s12034-020-2064-1

Cited by 29 publications

(8 citation statements)

References 26 publications

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“…The early and late apoptosis were almost similar while the necrosis rate was significantly lower than the results of Ebrahimzadeh. This indicates the lower side effect of nanoparticles synthesized with Juniperus chinensis than Anabaena flos-aquae (Ebrahimzadeh et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

Noorbazargan¹,

amintehrani²,

Dolatabadi³

et al. 2021

AMB Expr

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The current study evaluated the anti-cancer properties of bio-functionalized silver nanoparticles fabricated by Juniperus chinensis leaf extracts. The nanoparticles were characterized by scanning electron microscopy, transmission electron microscopy, UV–visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, dynamic light scattering, Zeta potential and X-ray spectroscopy. Further, this study elucidated the cellular and molecular mechanisms of nanoparticles for anti-proliferative and apoptotic effects on human lung cancer cells (A549) and compared them with commercial drug cisplatin. The size of the spherical nanoparticle was 12.96 nm with negative zeta potential. Up-regulation of caspase 3,9 and p53, Annexin V-FITC/PI, DAPI staining, and ROS production indicated the remarkable apoptotic effect of AgNPs compared to cisplatin. Moreover, down-regulation of MMP2/MMP9 scratch and matrigel assays revealed anti-metastatic properties of AgNPs. Cell cycle analysis and downregulation of cyclin D1 indicated cancer cell cessation in the G0/G1 phase. Overall, the results revealed that the green-synthetized AgNPs had anti-metastasis and anti-proliferation effects on lung cancer cells in comparison to cisplatin with lower side effects on the normal cell line.

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Section: Discussionmentioning

confidence: 99%

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

Noorbazargan¹,

amintehrani²,

Dolatabadi³

et al. 2021

AMB Expr

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“…Silver nanoparticles (AgNPs) have attracted wide attention due to their multiple applications in antibacterial [1][2][3][4], photocatalytic [5], medical [6], optical [7][8][9], and electrical felds [10][11][12], leading to commercialized and industrial applications. AgNPs have been synthesized by various chemical methods, which are expensive and use toxic chemical reagents [13].…”

Section: Introductionmentioning

confidence: 99%

Phytotoxicity and Antimicrobial Activity of Green Synthesized Silver Nanoparticles Using Nigella sativa Seeds on Wheat Seedlings

Elshazly

Mohamed

Aboelmagd

et al. 2022

Journal of Chemistry

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Recently, the green synthesis of nanomaterials has grown in popularity and has become one of the most used approaches. Plant extracts are safe for the environment and could be cost-effective for nanoparticle preparation. Silver nanoparticles (AgNPs) have been synthesized using aqueous extracts of Nigella sativa (N. sativa) seeds. The formation of AgNPs was confirmed by using an X-ray diffractometer, a UV-visible spectrometer, and a transmission electron microscope. The phytotoxicity and genotoxicity of different AgNP concentrations (12.5, 25, 50, 75, and 100 μg·L−1) were evaluated by wheat (Triticum aestivum L.) seed germination. The results showed that AgNPs did not significantly affect germination, while root and coleoptile lengths decreased considerably. On the contrary, the biomass of seedlings markedly increased in response to AgNP treatments. Moreover, genotoxicity was detected, especially at high concentrations of AgNPs. DNA, RNA, and total soluble proteins of wheat seedlings significantly decreased. In addition, antimicrobial activities of biosynthesized AgNPs were detected.

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“…The described Ag NPs mechanisms of action are visually represented in Figure 3; similar paths have also been proposed for other noble metal-based nanoparticles, including Au NPs [13,46], platinum NPs [47], and palladium NPs [48]. Significant results concerning Ag NPs antitumor activity were reported against several human cancer cell lines [43] (Table 1), including hepatocellular carcinoma [51][52][53], breast cancer [54][55][56][57], ovarian cancer [58,59], prostate cancer [60][61][62], colon cancer [30,[63][64][65][66], lung cancer [58,60,67,68], and osteosarcoma [69,70].…”

Section: Silver Npsmentioning

confidence: 52%

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

et al. 2022

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Cancer continues to represent a global health concern, imposing an ongoing need to research for better treatment alternatives. In this context, nanomedicine seems to be the solution to existing problems, bringing unprecedented results in various biomedical applications, including cancer therapy, diagnosing, and imaging. As numerous studies have uncovered the advantageous properties of various nanoscale metals, this review aims to present metal-based nanoparticles that are most frequently employed for cancer applications. This paper follows the description of relevant nanoparticles made of metals, metal derivatives, hybrids, and alloys, further discussing in more detail their potential applications in cancer management, ranging from the delivery of chemotherapeutics, vaccines, and genes to ablative hyperthermia therapies and theranostic platforms.

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Silver nanoparticles biosynthesized by Anabaena flos-aquae enhance the apoptosis in breast cancer cell line

Cited by 29 publications

References 26 publications

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

Phytotoxicity and Antimicrobial Activity of Green Synthesized Silver Nanoparticles Using Nigella sativa Seeds on Wheat Seedlings

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

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