Silver-embedded starch-based nanofibrous mats for soft tissue engineering

Wadke, Pallavi Ravindra; Chhabra, Rohan; Jain, Ratnesh; Dandekar, Prajakta

doi:10.1016/j.surfin.2017.05.008

Cited by 33 publications

(18 citation statements)

References 25 publications

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“…The in vitro antibacterial efficacy of the nanofibrous mats loaded with Ag nanoparticles was higher in E. coli than S. aureus . The biodegradation experiments in vitro demonstrated that PVA-starch-based nanofibrous mats incubated in PBS solution containing lysozyme showed the highest weight loss of approximately 19.24 ± 0.57% in the first week compared with plain PBS at pH 7.4, indicating that the mats are biodegradable and can significantly accelerate skin regeneration [ 93 ].…”

Section: Nanofibrous Materials For Wound Managementmentioning

confidence: 99%

Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

et al. 2021

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The treatment of wounds is expensive and challenging. Most of the available wound dressings are not effective and suffer from limitations such as poor antimicrobial activity, toxicity, inability to provide suitable moisture to the wound and poor mechanical performance. The use of inappropriate wound dressings can result in a delayed wound healing process. Nanosize range scaffolds have triggered great attention because of their attractive properties, which include their capability to deliver bioactive agents, high surface area, improved mechanical properties, mimic the extracellular matrix (ECM), and high porosity. Nanofibrous materials can be further encapsulated/loaded with metal-based nanoparticles to enhance their therapeutic outcomes in wound healing applications. The widely studied metal-based nanoparticles, silver nanoparticles exhibit good properties such as outstanding antibacterial activity, display antioxidant, and anti-inflammatory properties, support cell growth, making it an essential bioactive agent in wound dressings. This review article reports the biological (in vivo and in vitro) and mechanical outcomes of nanofibrous scaffolds loaded with silver nanoparticles on wound healing.

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Section: Nanofibrous Materials For Wound Managementmentioning

confidence: 99%

Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

et al. 2021

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“…The nanofibers were cut into 1 × 1 cm 2 pieces, and an electronic balance measured their dry weight (W d ). After that, the samples were placed in PBS for 24 h. At determined intervals of time (0.5, 1, 2, 4, 8, 12, 16, 20, and 24 h), the samples were taken, and their wet weight (W w ) was measured by placing them on filter paper for about 10 min to entrap moisture present in the nanofibers’ pores, then they were weighed [ 22 ]. The average swelling index was calculated by using the following equation:

where W w = weight of the wet nanofiber scaffold and W d = dried weight.…”

Section: Methodsmentioning

confidence: 99%

Electrospun Biomimetic Multifunctional Nanofibers Loaded with Ferulic Acid for Enhanced Antimicrobial and Wound-Healing Activities in STZ-Induced Diabetic Rats

et al. 2022

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Diabetic foot ulceration is the most distressing complication of diabetes having no standard therapy. Nanofibers are an emerging and versatile nanotechnology-based drug-delivery system with unique wound-healing properties. This study aimed to prepare and evaluate silk-sericin based hybrid nanofibrous mats for diabetic foot ulcer. The nanofibrous mats were prepared by electrospinning using silk sericin mixed with different proportions of polycaprolactone (PCL) and cellulose acetate (CA) loaded with ferulic acid (FA). The in vitro characterizations, such as surface morphology, mechanical properties, swelling behavior, biodegradability, scanning electron microscopy, and drug release were carried out. The SEM images indicated that nanofibers formed with varied diameters, ranging from 100 to 250 nm, and their tensile strength was found to range from 7 to 15 MPa. In vitro release demonstrated that the nanofibers sustained FA release over an extended time of period. In vitro cytotoxicity showed that the nanofibers possessed a lower cytotoxicity in HaCaT cells. The in vivo wound-healing studies demonstrated an excellent wound-healing efficiency of the nanofibers in diabetic rats. Furthermore, the histopathological studies showed the nanofibers’ ability to restore the skin’s normal structure. Therefore, it was concluded that the prepared silk-sericin-based hybrid nanofibers loaded with FA could be a promising drug-delivery platform for the effective treatment of diabetic foot ulcers.

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“…Potato starch was kindly gifted by Signet Chemical Corporation Pvt. Ltd., Mumbai, India [14] . Absolute ethanol and glutaraldehyde were received from SD fine Chem.…”

Section: Methodsmentioning

confidence: 99%

Starch based nanofibrous scaffolds for wound healing applications

Waghmare

Wadke

Dyawanapelly

et al. 2018

Bioactive Materials

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127

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Starch is an attractive polymer for wound healing applications because of its wide availability, low cost, biocompatibility, biodegradability and wound-healing property. Here, we have fabricated starch-based nanofibrous scaffolds by electrospinning for wound healing applications. The diameter of the optimized nanofibers was determined by field emission scanning electron microscopy (FE-SEM) and was found to be in the range of 110–300 nm. The mechanical strength (0.5–0.8 MPa) of the nanofibrous scaffolds was attuned using polyvinyl alcohol (plasticizer) and glutaraldehyde (crosslinking agent), to impart them with sufficient durability for skin tissue engineering. Absence of negative interactions between the polymers was confirmed by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), differential scanning microscopy (DSC) and thermal gravimetric analysis (TGA). Cellular assays with L929 mouse fibroblast cells indicated the ability of the scaffolds to promote cellular proliferation, without exhibiting any toxic effect to the cells. Thus, the nanofibrous scaffolds demonstrated potential for wound healing applications.

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Silver-embedded starch-based nanofibrous mats for soft tissue engineering

Cited by 33 publications

References 25 publications

Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

Electrospun Biomimetic Multifunctional Nanofibers Loaded with Ferulic Acid for Enhanced Antimicrobial and Wound-Healing Activities in STZ-Induced Diabetic Rats

Starch based nanofibrous scaffolds for wound healing applications

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