Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials

Abstract

The treatment of wounds is expensive and challenging. Most of the available wound dressings are not effective and suffer from limitations such as poor antimicrobial activity, toxicity, inability to provide suitable moisture to the wound and poor mechanical performance. The use of inappropriate wound dressings can result in a delayed wound healing process. Nanosize range scaffolds have triggered great attention because of their attractive properties, which include their capability to deliver bioactive agents, high surface area, improved mechanical properties, mimic the extracellular matrix (ECM), and high porosity. Nanofibrous materials can be further encapsulated/loaded with metal-based nanoparticles to enhance their therapeutic outcomes in wound healing applications. The widely studied metal-based nanoparticles, silver nanoparticles exhibit good properties such as outstanding antibacterial activity, display antioxidant, and anti-inflammatory properties, support cell growth, making it an essential bioactive agent in wound dressings. This review article reports the biological (in vivo and in vitro) and mechanical outcomes of nanofibrous scaffolds loaded with silver nanoparticles on wound healing.

Mechanic-Driven Biodegradable Polyglycolic Acid/Silk Fibroin Nanofibrous Scaffolds Containing Deferoxamine Accelerate Diabetic Wound Healing

“…Thus, electrospun nanofibrous scaffolds are considered one of the most promising biomaterials for diabetic wound healing. However, conventional nanofibrous scaffolds still have some disadvantages and limit their applications, such as poor mechanical properties [ 19 ], high immunogenicity [ 20 ], poor stability [ 21 ], and slow rate of degradation [ 22 ]. Among them, one of the most important shortcomings is that some wound dressings need to be removed [ 15 , 23 ], which easily causes secondary damage before the wound is completely healed.…”

Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances

“…Ideally, fiber diameters at the nanometric scale make their structure suitable to bio-mimic the natural extracellular matrix (ECM) of tissue, thus providing a friendly environment for the regeneration of the target site and facilitating repair mechanisms [ 33 , 34 , 35 ]. In addition to topographical fibers resembling native ECM architecture, they can also influence cell migration, adhesion, differentiation, and regeneration [ 36 , 37 , 38 , 39 , 40 , 41 ].…”

Study of parameter affecting morphology of electrospun poly (lactic acid) (PLA) fibers loaded with Ag/CaCO3 filler

“…Silver nanoparticles (AgNPs) are widely used as antimicrobial agent in health care, food and commercial products like textiles. AgNPs have now been established as an effective biocidal agent and act on a wide range of both gram-negative and gram-positive bacteria [1]. AgNPs incorporated into polymer matrix are currently a popular type of nanocomposite that can provide excellent antimicrobial properties.…”