Silicon photonic biosensors

Ciminelli, Caterina; Dell’Olio, Francesco; Conteduca, Donato; Armenise, Mario Nicola

doi:10.1049/iet-opt.2018.5082

Cited by 17 publications

(17 citation statements)

References 55 publications

(49 reference statements)

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“…This is possible due to the extraordinary attributes of optical biosensors, such as high sensitivity, being label-free, robustness, immunity to electromagnetic interference, having computable optical outputs, being amenable to miniaturization, integration capabilities, portability [ 65 , 66 ], multiplexing capability and providing concurrent detection of various targets ( Figure 5 ). Therefore, optical biosensors are suitable for the point-of-care zone [ 67 , 68 ]. Researchers from Empa and ETH Zurich (Zürich, Switzerland) were successful at developing an optical sensor for SARS-CoV-2 [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Biosensors as Nano-Analytical Tools for COVID-19 Detection

Pradhan

Lahare

Sinha

et al. 2021

Sensors

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Selective, sensitive and affordable techniques to detect disease and underlying health issues have been developed recently. Biosensors as nanoanalytical tools have taken a front seat in this context. Nanotechnology-enabled progress in the health sector has aided in disease and pandemic management at a very early stage efficiently. This report reflects the state-of-the-art of nanobiosensor-based virus detection technology in terms of their detection methods, targets, limits of detection, range, sensitivity, assay time, etc. The article effectively summarizes the challenges with traditional technologies and newly emerging biosensors, including the nanotechnology-based detection kit for COVID-19; optically enhanced technology; and electrochemical, smart and wearable enabled nanobiosensors. The less explored but crucial piezoelectric nanobiosensor and the reverse transcription-loop mediated isothermal amplification (RT-LAMP)-based biosensor are also discussed here. The article could be of significance to researchers and doctors dedicated to developing potent, versatile biosensors for the rapid identification of COVID-19. This kind of report is needed for selecting suitable treatments and to avert epidemics.

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Section: Discussionmentioning

confidence: 99%

Biosensors as Nano-Analytical Tools for COVID-19 Detection

Pradhan

Lahare

Sinha

et al. 2021

Sensors

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“… 37 , 38 Therefore, optical biosensors are excellent candidates to move the analysis from centralized laboratories to the point-of-care. 39 , 40 Optical biosensors measure variations of the optical properties of the propagated light (i.e., absorption, polarization, intensity, wavelength, dispersion, or refractive index) when the interaction between the receptor (antibody, nucleic acid sequences, enzymes, proteins, etc.) and the target analyte takes place.…”

Section: Diagnostic Strategies For Respiratory Virus Infectionmentioning

confidence: 99%

“…The vast knowledge and robustness of silicon-based technologies, including conventional microelectronics fabrication and characterization procedures, together with the low power consumption and the capability to incorporate all the functions (chemical, optical, microfluidics, and electronics) in one single platform, make these systems ideal for lab-on-a-chip implementation and use as point-of-care diagnostics. 40 , 41 …”

Section: Nanophotonic Biosensors: Working Principles and Technologiesmentioning

confidence: 99%

How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections: COVID-19 Case

et al. 2020

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The global sanitary crisis caused by the emergence of the respiratory virus SARS-CoV-2 and the COVID-19 outbreak has revealed the urgent need for rapid, accurate, and affordable diagnostic tests to broadly and massively monitor the population in order to properly manage and control the spread of the pandemic. Current diagnostic techniques essentially rely on polymerase chain reaction (PCR) tests, which provide the required sensitivity and specificity. However, its relatively long time-to-result, including sample transport to a specialized laboratory, delays massive detection. Rapid lateral flow tests (both antigen and serological tests) are a remarkable alternative for rapid point-of-care diagnostics, but they exhibit critical limitations as they do not always achieve the required sensitivity for reliable diagnostics and surveillance. Next-generation diagnostic tools capable of overcoming all the above limitations are in demand, and optical biosensors are an excellent option to surpass such critical issues. Label-free nanophotonic biosensors offer high sensitivity and operational robustness with an enormous potential for integration in compact autonomous devices to be delivered out-of-the-lab at the point-of-care (POC). Taking the current COVID-19 pandemic as a critical case scenario, we provide an overview of the diagnostic techniques for respiratory viruses and analyze how nanophotonic biosensors can contribute to improving such diagnostics. We review the ongoing published work using this biosensor technology for intact virus detection, nucleic acid detection or serological tests, and the key factors for bringing nanophotonic POC biosensors to accurate and effective COVID-19 diagnosis on the short term.

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“…There are many different types of optical sensors. Among them are photonic and plasmonic biosensors, which have high sensitivity and do not require amplification as the RT-LAMP and RT-PCR [113][114][115]. The detection process starts with an evanescent wave forming as light travels in a medium and undergoes internal reflection (TIR).…”

Section: Optical Biosensormentioning

confidence: 99%

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

et al. 2021

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COVID-19, also known as SARS-CoV-2 is a novel, respiratory virus currently plaguing humanity. Genetically, at its core, it is a single-strand positive-sense RNA virus. It is a beta-type Coronavirus and is distinct in its structure and binding mechanism compared to other types of coronaviruses. Testing for the virus remains a challenge due to the small market available for at-home detection. Currently, there are three main types of tests for biomarker detection: viral, antigen and antibody. Reverse Transcription-Polymerase Chain Reaction (RT-PCR) remains the gold standard for viral testing. However, the lack of quantitative detection and turnaround time for results are drawbacks. This manuscript focuses on recent advances in COVID-19 detection that have lower limits of detection and faster response times than RT-PCR testing. The advancements in sensing platforms have amplified the detection levels and provided real-time results for SARS-CoV-2 spike protein detection with limits as low as 1 fg/mL in the Graphene Field Effect Transistor (FET) sensor. Additionally, using multiple biomarkers, detection levels can achieve a specificity and sensitivity level comparable to that of PCR testing. Proper biomarker selection coupled with nano sensing detection platforms are key in the widespread use of Point of Care (POC) diagnosis in COVID-19 detection.

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Silicon photonic biosensors

Cited by 17 publications

References 55 publications

Biosensors as Nano-Analytical Tools for COVID-19 Detection

Biosensors as Nano-Analytical Tools for COVID-19 Detection

How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections: COVID-19 Case

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

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