Silicon in Biological Material. II. Variations in Silicon Contents in Tissues of Rat at Different Ages

Leslie, James G.; Kao, Kung-Ying Tang; McGavack, Thomas H.

doi:10.3181/00379727-110-27470

Cited by 13 publications

(5 citation statements)

References 2 publications

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“…17 found a decline in silicon content with age in rat skin compared with other tissues, such as brain, liver, spleen, lung and femur, where the silicon content increased.…”

Section: Discussionmentioning

confidence: 92%

Colloidal Silicic Acid for Oral and Topical Treatment of Aged Skin, Fragile Hair and Brittle Nails in Females

Lassus¹

1993

J Int Med Res

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In an open study, women with biologically aged skin and fragile or thin hair, or brittle nails were treated orally with 10 ml colloidal silicic acid (Silicol) once daily for 90 days and applied colloidal silicic acid to the face for 10 min twice daily. Of the 50 subjects treated, three withdrew from treatment after 30 days because of excessive drying of the facial skin due to topical application. In the remaining 47 subjects there was statistically significant improvement in the thickness and turgor of the skin, wrinkles and condition of the hair and nails. The number of mottles also declined, but the change was not statistically significant. Ultrasound measurements did not detect any statistically significant change in the thickness of the epidermis or elasticity of the skin, but there was a significant increase in the thickness of the dermis.

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“…17 found a decline in silicon content with age in rat skin compared with other tissues, such as brain, liver, spleen, lung and femur, where the silicon content increased.…”

Section: Discussionmentioning

confidence: 92%

Colloidal Silicic Acid for Oral and Topical Treatment of Aged Skin, Fragile Hair and Brittle Nails in Females

Lassus¹

1993

J Int Med Res

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“…During attempts to identify the binding site of Si we discovered that certain glycosaminoglyeans, * Reported Si amounts vary greatly, depending on the analytical methods used. A large number of results (9, 10) obtained before development of suitable methods (11,12) and the advent of plastic laboratory ware are much higher than those found more recently (8,13 …”

Section: Introductionmentioning

confidence: 90%

A Bound Form of Silicon in Glycosaminoglycans and Polyuronides

Schwarz

1973

Proc. Natl. Acad. Sci. U.S.A.

298

121

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Silicon was found to be a constituent of certain glycosaminoglycans and polyuronides, where it occurs firmly bound to the polysaccharide matrix. 330-554 ppm of bound Si were detected in purified hyaluronic acid from umbilical cord, chondroitin 4-sulfate, dermatan sulfate, and heparan sulfate. These amounts correspond to 1 atom of Si per 50,000-85,000 molecular weight or 130-280 repeating units. 57-191 Silicon (Si) is essential for growth and general development (1). In all-plastic isolators that exclude the element from the environment (2, 3), growth of rats is reduced by 30-35% when Si-deficient aminoacid diets are fed, and bone deformations develop. Dietary supplements of silicate prevent these symptoms. Similar findings have been reported for chicks (4). Si, moreover, is needed in rats for normal pigment formation in the enamel of incisors (5).Even though it has been known for years that Si occurs in small, varying amounts in all animals, very little concrete evidence exists about its functional significance and biochemical behavior (6, 7). In mammals, Si occurs most abundantly in connective tissue and related structures. While amounts in blood and parenchymal organs are relatively low, the Si content of skin, cartilage, ligaments, and other tissues of mainly mesodermal origin frequently exceeds 100 ,g/g dry wt (8)*.In extensive experiments with cartilage and bovine-nasal septum we found Si to be strongly bound -to the organic matrix of these tissues. During attempts to identify the binding site of Si we discovered that certain glycosaminoglyeans, * Reported Si amounts vary greatly, depending on the analytical methods used. A large number of results (9, 10) obtained before development of suitable methods (11,12) and the advent of plastic laboratory ware are much higher than those found more recently (8,13

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“…Loeper et al (1978) reported that the concentration of silicon in the arterial wall of humans decreases with the development of atherosclerosis. Leslie et al (1962) found that, although silicon levels decreased in skin, the silicon concentrations of most organs (e.g., kidney, brain, liver, spleen, and lung) increased with aging.…”

Section: General Information On the Metabolic Fate Of Siliconmentioning

confidence: 98%

Calcium silicate and silicon dioxide/silicic acid gel added for nutritional purposes to food supplements

2009

EFS2

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Silicon in Biological Material. II. Variations in Silicon Contents in Tissues of Rat at Different Ages

Cited by 13 publications

References 2 publications

Colloidal Silicic Acid for Oral and Topical Treatment of Aged Skin, Fragile Hair and Brittle Nails in Females

Colloidal Silicic Acid for Oral and Topical Treatment of Aged Skin, Fragile Hair and Brittle Nails in Females

A Bound Form of Silicon in Glycosaminoglycans and Polyuronides

Calcium silicate and silicon dioxide/silicic acid gel added for nutritional purposes to food supplements

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