Silica nanoparticles with a substrate switchable luminescence

Bochkova, Olga; Mustafina, Asiya R.; Fedorenko, Svetlana V.; Коновалов, А. И.

doi:10.1088/1742-6596/291/1/012038

Cited by 4 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Minocycline-loaded nanoparticles stored at 4 °C were stable and displayed greater uniformity in their particle size measurements during all time periods. For PDI values, nanoparticles stored at both 25 °C and 4 °C conditions exhibited a value of <0.3, in accordance with the acceptable limit of monodispersed nanoparticle distribution [ 72 , 96 , 97 ]. Nonetheless, increased PDI was also observed over the 2-month time period under all conditions except the lyophilized powder stored at 4 °C.…”

Section: Resultssupporting

confidence: 65%

Enhanced Targeted Delivery of Minocycline via Transferrin Conjugated Albumin Nanoparticle Improves Neuroprotection in a Blast Traumatic Brain Injury Model

et al. 2023

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is a major source of death and disability worldwide as a result of motor vehicle accidents, falls, attacks and bomb explosions. Currently, there are no FDA-approved drugs to treat TBI patients predominantly because of a lack of appropriate methods to deliver drugs to the brain for therapeutic effect. Existing clinical and pre-clinical studies have shown that minocycline’s neuroprotective effects either through high plasma protein binding or an increased dosage requirement have resulted in neurotoxicity. In this study, we focus on the formulation, characterization, in vivo biodistribution, behavioral improvements, neuroprotective effect and toxicity of transferrin receptor-targeted (tf) conjugated minocycline loaded albumin nanoparticles in a blast-induced TBI model. A novel tf conjugated minocycline encapsulated albumin nanoparticle was developed, characterized and quantified using a validated HPLC method as well as other various analytical methods. The results of the nanoformulation showed small, narrow hydrodynamic size distributions, with high entrapment, loading efficiencies and sustained release profiles. Furthermore, the nanoparticle administered at minimal doses in a rat model of blast TBI was able to cross the blood–brain barrier, enhanced nanoparticle accumulation in the brain, improved behavioral outcomes, neuroprotection, and reduced toxicity compared to free minocycline. Hence, tf conjugated minocycline loaded nanoparticle elicits a neuroprotective effect and can thus offer a potential therapeutic effect.

show abstract

Section: Resultssupporting

confidence: 65%