Interfacial adsorption and stripping of ions as a reason of stimuli responsive luminescence of Tb-doped silica nanoparticles

Skripacheva, V. V.; Mustafina, Asiya R.; Davydov, Nikolay A.; Burilov, Vladimir; Коновалов, А. И.; Solov’eva, S. E.; Антипин, И. С.

doi:10.1016/j.matchemphys.2011.11.058

Cited by 9 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in general, fluorescence properties of lanthanide complexes [36] undergo a significant deterioration in water due to quenching phenomena. In agreement with reported results [29,30,31,32,36,37,38], in general, a significantly improved photochemical stability can be achieved by taking advantage of the lanthanide complex encapsulation within a protecting silica shell, able to inhibit quenching phenomena due to diffusion of environmental ions or ligands and deterioration of the lanthanide-antenna ligands [32,36,37,38]. In addition, the functionalization of the SNs surface with NH 2 groups allow them to be suitably conjugated to the TSPO ligands, as they expose a derivatizable carboxylic end group.…”

Section: Introductionsupporting

confidence: 94%

“…In particular, the pH-induced deprotonation of the Tb III -TCAS complex in the synthetic conditions of SN22 can be accompanied by its partial degradation due to contribution of Tb III hydrolysis. The UV-Vis absorbance line profile (Figure 1E) shows two faint bands at 245 nm and 316 nm, ascribable to the electronic transition of the Tb III -TCAS complex [29,30,31,32,39,43], superimposed to the low absorption and the high scattering of the silica matrix in the UV region, which is almost transparent in the visible range. Tb III -TCAS complex absorption features are very clearly visible in the absorption spectrum of the SN22, while only slightly perceptible in SN46, probably because in the latter case they are hidden by the large scattering contribution due to the thicker silica matrix.…”

Section: Resultsmentioning

confidence: 99%

“…Activation of the antenna mechanism using TCAS occurs in the excitation range between 300 and 400 nm where the phenolate sulfonate rings of the TCAS can absorb light inducing Tb 3+ sensitization by an energetically favored singlet-triplet intersystem crossing transition (in the TCAS antenna), followed by energy transfer from the TCAS to the terbium centre [51]. Additional advantages are gained by encapsulating the Tb III -TCAS complex inside the silica matrix [29,30,31,32]. The hydrophilicity of the silica shell balances the poor solubility in water of the Tb III -TCAS complex.…”

Section: Discussionmentioning

confidence: 99%

“…Here, two samples of nonporous colloidal SNs, with average size of 22 nm and 46 nm, decorated with amino (NH 2 ) groups and hosting a fluorescent probe, based on lanthanide complex, have been synthesized by means of a microemulsion approach, according to previously reported strategies [29,30,31,32], and further conjugated to a synthetic TSPO ligand based on 2-phenylimidazo[1,2-a]pyridine acetamide structure, containing derivatizable carboxylic end groups. Among the several type of ligands [20,21] used to target the TSPO receptor, the imidazopyridine acetamide based structures have been proved to selectively and specifically target the mitochondrial outer membrane TSPO protein [2,8].…”

Section: Introductionmentioning

confidence: 99%

“…According to the former mechanism, the photophysical properties of the Tb III complex are characterized by narrow emission bands, large Stokes shift, larger than those of organic molecules, long lifetime and, moreover, they facilitate background elimination. The proposed Tb III -TCAS complex is based on a multicentered coordination of metal ions by means of calix[4]arene rims and it is characterized by efficient luminescence and good hydrophilicity both in neutral and weakly alkaline media [29,30,31,32]. However, in general, fluorescence properties of lanthanide complexes [36] undergo a significant deterioration in water due to quenching phenomena.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles for TSPO Targeting

Fanizza

Depalo

Fedorenko

et al. 2019

IJMS

Self Cite

View full text Add to dashboard Cite

The low photostability of conventional organic dyes and the toxicity of cadmium-based luminescent quantum dots have prompted the development of novel probes for in vitro and in vivo labelling. Here, a new fluorescent lanthanide probe based on silica nanoparticles is fabricated and investigated for optically traceable in vitro translocator protein (TSPO) targeting. The targeting and detection of TSPO receptor, overexpressed in several pathological states, including neurodegenerative diseases and cancers, may provide valuable information for the early diagnosis and therapy of human disorders. Green fluorescent terbium(III)-calix[4]arene derivative complexes are encapsulated within silica nanoparticles and surface functionalized amine groups are conjugated with selective TSPO ligands based on a 2-phenylimidazo[1,2-a]pyridine acetamide structure containing derivatizable carboxylic groups. The photophysical properties of the terbium complex, promising for biological labelling, are demonstrated to be successfully conveyed to the realized nanoarchitectures. In addition, the high degree of biocompatibility, assessed by cell viability assay and the selectivity towards TSPO mitochondrial membrane receptors, proven by subcellular fractional studies, highlight targeting potential of this nanostructure for in vitro labelling of mitochondria.

show abstract

Section: Introductionsupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles for TSPO Targeting

Fanizza

Depalo

Fedorenko

et al. 2019

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Complex Formation of d‐Metal Ions at the Interface of Tb^III‐Doped Silica Nanoparticles as a Basis of Substrate‐Responsive Tb^III‐Centered Luminescence

et al. 2012

View full text Add to dashboard Cite

The complex formation of d-metal ions at the interface of Tb(III)-doped silica nanoparticles modified by amino groups is introduced as a route to sensing d-metal ions and some organic molecules. Diverse modes of surface modification (covalent and noncovalent) are used to fix amino groups onto the silica surface. The interfacial binding of d-metal ions and complexes is the reason for the Tb(III)-centered luminescence quenching. The regularities and mechanisms of quenching are estimated for the series of d-metal ions and their complexes with chelating ligands. The obtained results reveal the interfacial binding of Cu(II) ions as the basis of their quantitative determination in the concentration range 0.1-2.5 μM by means of steady-state and time-resolved fluorescence measurements. The variation of chelating ligands results in a significant effect on the quenching regularities due to diverse binding modes (inner or outer sphere) between amino groups at the interface of nanoparticles and Fe(III) ions. The applicability of the steady-state and time-resolved fluorescence measurements to sense both Fe(III) ions and catechols in aqueous solution by means of Tb(III)-doped silica nanoparticles is also introduced.

show abstract

The effect of the core morphology of Eu(III)-doped nanoparticles on the ion exchange versus energy transfer between Eu(III) in the core and Cu(II) ions at the interface

et al. 2012

Self Cite

View full text Add to dashboard Cite

The report represents the comparative analysis of luminescent properties of Eu(III) complex in colloids of silica-coated and layer-by-layer-fabricated nanoparticles. The diverse morphologies of these nanoparticles greatly affect their photophysical properties. The interfacial binding with d-ions exemplified by Cu(II) and the contributions of the ion exchange and energy transfer processes between Eu(III) ions confined within polymeric coating and Cu(II) ions at the interface of nanoparticles also depend on their morphology. The silica coating of Eu(III) complex does not prevent it from the efficient ion displacement by the interfacial Cu(II) ions, which results in the irreversible quenching of Eu(III)-centered luminescence. The lack of the ion exchange and the predominant energy transfer between Eu(III) ions in the core and interfacial Cu(II) ions are revealed in the colloids of Eu(III) complex reprecipitated from organic to aqueous solution and coated by the layerby-layer-fabricated polyelectrolyte multilayer. The obtained results represent the synthetic route of the insertion of Cu(II) ions into the polyelectrolyte multilayer fabricated onto Eu(III) complex.

show abstract

Interfacial adsorption and stripping of ions as a reason of stimuli responsive luminescence of Tb-doped silica nanoparticles

Cited by 9 publications

References 34 publications

Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles for TSPO Targeting

Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles for TSPO Targeting

Complex Formation of d‐Metal Ions at the Interface of Tb^III‐Doped Silica Nanoparticles as a Basis of Substrate‐Responsive Tb^III‐Centered Luminescence

The effect of the core morphology of Eu(III)-doped nanoparticles on the ion exchange versus energy transfer between Eu(III) in the core and Cu(II) ions at the interface

Contact Info

Product

Resources

About

Interfacial adsorption and stripping of ions as a reason of stimuli responsive luminescence of Tb-doped silica nanoparticles

Cited by 9 publications

References 34 publications

Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles for TSPO Targeting

Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles for TSPO Targeting

Complex Formation of d‐Metal Ions at the Interface of TbIII‐Doped Silica Nanoparticles as a Basis of Substrate‐Responsive TbIII‐Centered Luminescence

The effect of the core morphology of Eu(III)-doped nanoparticles on the ion exchange versus energy transfer between Eu(III) in the core and Cu(II) ions at the interface

Contact Info

Product

Resources

About

Complex Formation of d‐Metal Ions at the Interface of Tb^III‐Doped Silica Nanoparticles as a Basis of Substrate‐Responsive Tb^III‐Centered Luminescence