Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment

Lu, Ping; Mamiya, Takayoshi; Lu, Lingling; Mouri, Akihiro; Niwa, Minae; Kim, Hyoung Chun; Zou, Li; Nagai, Taku; Yamada, Kiyofumi; Ikejima, Takashi; Nabeshima, Toshitaka

doi:10.1016/j.bbr.2009.10.024

Cited by 81 publications

(47 citation statements)

References 48 publications

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“…On the other hand, dopamine and serotonin levels gave positive results via S. marianum seeds extract or S. marianum seeds oil fraction treatment for irradiated rats. In the case of pharmacological stress caused by methamphetamine treatment, silibinin attenuated the decreases of dopamine levels in the prefrontal cortex and serotonin levels in the hippocampus [46]. Silymarin showed an antioxidant effect in the central nervous system, being able to cross the blood-brain barrier [47].…”

Section: Discussionmentioning

confidence: 99%

POTENTIAL ROLE OF MILK THISTLE SEED AND ITS OIL EXTRACTS AGAINST HEART AND BRAIN INJURIES INDUCED BY Γ-Radiation EXPOSURE

Sherif

Hawas

Abdallah

et al. 2017

Int J Pharm Pharm Sci

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Objective: This study aimed to investigate the protective effect of Silybum marianum (S. marianum) seeds extract its oil fraction against damage effect of γ-radiation in female albino rats.Methods: Ultrasonic-assisted extraction was used for the extraction of S. marianum seeds. Lipid patterns of S. marianum seeds oil were elucidated using gas chromatography-mass spectrometry (GC-MS). S. marianum seeds extract was analyzed using high-performance liquid chromatography (HPLC). Malondialdehyde (MDA), reduced glutathione (GSH) and metallothionein (MT) were estimated in heart and brain tissues of the examined rats. Lactate dehydrogenase (LDH) and creatine kinase-MB (CKMB) were measured in the serum of the examined rats, and the brain biomarkers; dopamine and serotonin were also measured. Results:The oil was found to be rich in linoleic acid (58.20%) and arachidic acid (23.38%). S. marianum seeds extract revealed the presence of taxifolin and six main active constituents of silymarin, including silydianin, silychristin, silybin A, silybin B, isosilybin A and isosilybin B. Treatment of γ-radiation damage effect using S. marianum seeds extract and its oil fraction led to a significant reduction of MDA levels in heart (139.6 and 165.5 nmol/g, respectively) and brain (158.5 and 135.2 nmol/g, respectively) tissues, however, significant increase of GSH levels in heart (316.4 and 293 mg/g, respectively) and brain (210.4 and 227 mg/g, respectively) tissues was observed, also a significant increase of dopamine levels (85.27 and 65.74 ng/g, respectively) and MT levels of heart tissues (108.5 and 70.52 mg/g, respectively) was observed. Conclusion:S. marianum seeds extract and its oil fraction showed a protective effect against γ-radiation-induced damage in heart and brain.

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Section: Discussionmentioning

confidence: 99%

POTENTIAL ROLE OF MILK THISTLE SEED AND ITS OIL EXTRACTS AGAINST HEART AND BRAIN INJURIES INDUCED BY Γ-Radiation EXPOSURE

Sherif

Hawas

Abdallah

et al. 2017

Int J Pharm Pharm Sci

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“…for 10 days, once per day (09:00). Saline-withdrawn and METH-withdrawn animals were treated with the same administration paradigm and left to spontaneously withdraw in their home-cages for a period of 7 days (unless otherwise stated), as previously described (Lu et al, 2010).…”

Section: Chronic Steady-dose Methamphetamine Administration Paradigmmentioning

confidence: 99%

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

et al. 2016

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Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype, Neuropharmacology (2016), doi: 10.1016/ j.neuropharm.2016.02.012. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…However, chronic, rather than acute, administration of moderate doses (p2 mg/kg daily) can impair cognitive performance, including measures of working memory (Lee et al, 2011;Nagai et al, 2007) and object recognition memory (Arai et al, 2009;Ito et al, 2007;Noda et al, 2010). In fact, administering mice 1 mg/kg of MA daily for 7 days produces reliable deficits in object recognition memory even when assessed at least 1 week after drug cessation (Kamei et al, 2006;Lu et al, 2010;Mizoguchi et al, 2011).…”

Section: Animals Exposed To Ma Will Show Cognitive Decline Particulamentioning

confidence: 99%

“…In animals, in addition to cognitive decline produced by chronic moderate (p2 mg/kg daily) or escalating doses of MA, concomitant alterations have been observed in D2-like dopamine receptor and dopamine transporter binding (DAT) (Groman et al, 2012), tissue levels of dopamine and serotonin (Lu et al, 2010), NMDA receptor binding (Lee et al, 2011), glutamate receptor (mGluR5) expression (Reichel et al, 2011), pyramidal neuron cell firing (Parsegian et al, 2011), and novelty-induced hyperphosphorylation of extracellular signal-related kinase 1/2 (Ito et al, 2007;Kamei et al, 2006;Nagai et al, 2007). In humans, cross-sectional studies likewise show differences in the brain structure and function between MA-dependent and healthy control participants (for reviews, see Berman et al (2008); Chang et al (2007); Salo and Fassbender (2012)).…”

Section: Ma Abuse Will Be Associated With Changes In the Human Brainmentioning

confidence: 99%

An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans

Dean

Groman

Morales

et al. 2012

Neuropsychopharmacol

203

127

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Methamphetamine (MA) is one of the most commonly abused illicit substances worldwide. Among other problems, abuse of the drug has been associated with reduced cognitive function across several domains. However, much of the literature has not attempted to differentiate cognitive difficulties caused by MA abuse from preexisting cognitive difficulties that are likely caused by other factors. Here, we address this question, evaluating evidence for a priori hypotheses pertaining to six lines of research: (a) animal studies; (b) crosssectional human studies; (c) a twin study; (d) studies of changes in cognition with abstinence from MA; (e) studies of changes in brain structure and function with abstinence from MA; and (f) studies of the relationship between the severity of MA abuse and the extent of cognitive deficits observed. Overall the findings were mixed, with some support for a causal relationship between MA abuse and cognitive decline, and other findings suggesting that there is no relationship. The preponderance of the data, however, does support the possibility that MA abuse causes cognitive decline, of unknown duration, in at least some users of the drug. When averaged across individuals, this decline is likely to be mild in early-to-middle adulthood. However, moderator variables are likely to contribute to the presence and/or severity of cognitive decline exhibited by a given individual.

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Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment

Cited by 81 publications

References 48 publications

POTENTIAL ROLE OF MILK THISTLE SEED AND ITS OIL EXTRACTS AGAINST HEART AND BRAIN INJURIES INDUCED BY Γ-Radiation EXPOSURE

POTENTIAL ROLE OF MILK THISTLE SEED AND ITS OIL EXTRACTS AGAINST HEART AND BRAIN INJURIES INDUCED BY Γ-Radiation EXPOSURE

Methamphetamine abstinence induces changes in μ-opioid receptor, oxytocin and CRF systems: Association with an anxiogenic phenotype

An Evaluation of the Evidence that Methamphetamine Abuse Causes Cognitive Decline in Humans

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