Silandiole: eine neue Klasse potenter Protease-Inhibitoren

Stereospecific Synthesis of α-Amino Allylsilane Derivatives through a [3,3]-Allyl Cyanate Rearrangement. Mild Formation of Functionalized Disiloxanes

“…39,40 At this stage, it is difficult to propose a rational mechanism for this catalytic reaction by lack of evidence, even if we cannot exclude that the presence at the α-position of an urea or carbamate carbonyl group could assist the Si−C bond cleavage by a possible internal coordination with the silicon atom. 41,42 To the best of our knowledge, this experimental procedure for the formation of functionalized disiloxane derivatives was not reported in the literature; however, this heterogeneous catalytic method suffers from drawbacks such as reproducibility according to the batch of catalyst used as well as its supplier. by the addition of a nucleophile, allowed the preparation of a small library of novel compounds.…”

Iron‐Catalyzed Intermolecular 1,2‐Difunctionalization of Styrenes and Conjugated Alkenes with Silanes and Nucleophiles

“…Specifically, the recently expanding studies of both silicon analogues of known drugs and entirely new silicon‐containing compounds have become an emerging leading research field in the pharmaceutical industry. For example, 1‐amino‐2‐silylalkanes exhibit fascinating biological activities which exist in many potential pharmaceuticals and drug lead compounds, such as Sila‐venlafaxine ( 1 ),, the compound 2 , and TMS‐alanine ( 3 ,; Figure ). Traditionally, synthesis of such 1‐amino‐2‐silylalkanes and other silicon‐containing amino compounds relies on the introduction of either the amino or silicon functional groups into the corresponding silicon‐based or amino‐based frameworks .…”

Synthesis of angiotensin-converting enzyme (ACE) inhibitors: an important class of antihypertensive drugs

“…Another interesting work performed by Sieburth and colleagues 40 reports the use of the ACE inhibitor model 35 for the design of the silanediol inhibitor 36. The diasteromeric mixture of 36 was tested as ACE inhibitor showing hopeful results.…”