Transition state analogues of the peptide hydrolysis intermediate can take the form of complex silanediols such as 1, which inhibits angiotensin-converting enzyme (ACE) at nanomolar concentrations. In contrast, earlier investigation of enzyme inhibition with simple silanediols and silanetriols showed them to be inactive.
Als Übergangszustandsanaloga für die Hydrolyse von Peptiden dienen komplexe Silandiole wie 1, die das Angiotensin Converting Enzyme (ACE) im nanomalaren Bereich inhibieren können. Einfache Silandiole und Silantriole haben sich hingegen bei früheren Versuchen, Enzyme zu inhibieren, als inaktiv erwiesen.
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