Synthesis of angiotensin-converting enzyme (ACE) inhibitors: an important class of antihypertensive drugs

Abstract

This report outlines the discovery, the design and development of new compounds, and, structure-activity relationships for this drug category. Updated approaches to planned syntheses of new worthy ACE-inhibitors are also exploited

Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus

“…RVVHPALHL in AVP78050.1 and ATYYHPNIRVGVFHD in ADV71747.1, none correspond to or lie near to the trypsin cleavage points in the SARS S glycoprotein. At best they only imaginatively match the S2 0 segment DPSKPSKRSFIEDLL, though the DP (aspartate-proline) in that is suggestive of some features of ACE inhibitors [41]. There is no obvious relation of the S protein cleavage sites with angiotensinogen.…”

COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles’ heel conserved region to minimize probability of escape mutations and drug resistance

“…The earlier methods of peptide synthesis did not achieve high levels of purity. However, this has changed and quite elaborate peptides as well as proteins can be made, facilitated by making peptide synthesizers run fast to avoid the slower side reactions, and by methods that join shorter synthetic peptides into longer chains [43][44][45][46].…”

“…refs [33]) and synthetic techniques (e.g. ref [43]). The Q-UEL language [33][34][35][36][37] used in the preceding work [3] is also a means of gathering relevant information from the World Wide Web efficiently when encountering a new problem such as an epidemic caused by a new virus, or at least a problem new to the researcher [3,4,38].…”

Radical scavenging and angiotensin converting enzyme inhibitory activities of standardized extracts of Ficus racemosa stem bark

“…As a result, ACE inhibitors have been widely developed to prevent angiotensin II production in cardiovascular diseases, and utilized in clinical applications since the discovery of ACE inhibitors in snake venom (Je et al, 2009). Although synthetic ACE inhibitors such as lisinopril, enalapril etc, are remarkably effective, they cause adverse side effects such as cough, angioedema, taste disturbances, skin rashes and allergic reactions (de Lima, 1999). Therefore, the search for natural, safe and effective ACE inhibitors with minimized adverse effects has been the focus of recent times.…”