Significantly high regional morbidity of MPO-ANCA–related angitis and/or nephritis with respiratory tract involvement after the 1995 great earthquake in Kobe (Japan)

Yashiro, Masatomo; Muso, Eri; Itoh-Ihara, Toshiko; Oyama, Atsushi; Hashimoto, Kimio; Kawamura, Tsuneo; Ono, Takahiko; Sasayama, Shígetake

doi:10.1016/s0272-6386(00)70260-5

Cited by 62 publications

(42 citation statements)

References 18 publications

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“…[48][49][50] A higher incidence of MPO-AAV was reported after the Kobe earthquake in Japan, possibly related to increased silica exposure. 51 After closure of the last coal mine in the region of Maastricht, the Netherlands, MPO-AAV diagnoses appeared to decrease compared with the number of PR3-AAV diagnoses. 52 Whether this observation supports the etiologic contribution of silica exposure is, however, speculative.…”

Section: Etiologymentioning

confidence: 94%

Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis

Hilhorst

Paassen

Tervaert

2015

Journal of the American Society of Nephrology

174

137

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In patients with GN or vasculitis, ANCAs are directed against proteinase 3 (PR3) or myeloperoxidase (MPO). The differences between PR3-ANCA-associated vasculitis (AAV) and MPO-AAV described in the past have been supplemented during the last decade. In this review, we discuss the differences between these two small-vessel vasculitides, focusing especially on possible etiologic and pathophysiologic differences. PR3-AAV is more common in northern parts of the world, whereas MPO-AAV is more common in southern regions of Europe, Asia, and the Pacific, with the exception of New Zealand and Australia. A genetic contribution has been extensively studied, and there is a high prevalence of the HLA-DPB1*04:01 allele in patients with PR3-AAV as opposed to patients with MPO-AAV and/or healthy controls. Histologically, MPO-AAV and PR3-AAV are similar but show qualitative differences when analyzed carefully. Clinically, both serotypes are difficult to distinguish, but quantitative differences are present. More organs are affected in PR3-AAV, whereas renal limited vasculitis occurs more often in patients with MPO-AAV. For future clinical trials, we advocate classifying patients by ANCA serotype as opposed to the traditional disease type classification.

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Section: Etiologymentioning

confidence: 94%

Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis

Hilhorst

Paassen

Tervaert

2015

Journal of the American Society of Nephrology

174

137

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“…1b). As a sensitive method of detecting rapid changes in renal dysfunction, we calculated the rate of change in 1/Cre before and after IVIg as shown previously [11]. The rate of change in 1/Cre was –0.041 ± 0.020 dl/mg/day before IVIg and increased to 0.007 ± 0.004 dl/mg/day after IVIg (p < 0.05).…”

Section: Resultsmentioning

confidence: 98%

“…To determine whether rapid progression of renal failure was occurring in these patients, the rate of change in reciprocal Cre (1/Cre) levels (dl/mg/day) was compared before and after IVIg treatment [11]. Briefly, Cre levels (mg/dl) were evaluated at five time pointsas follows: the first visit to the primary care physicianwith initial symptoms (Cre1 at time 1 [T1]), admission to the hospital (Cre2 at time 2 [T2]), transfer to the nephrology unit (Cre3 at time 3 [T3]), just before IVIg treatment (Cre4 at time 4 [T4]), and after IVIg treatment without receiving other immunosuppressive treatment (Cre5 at time 5 [T5]).…”

Section: Methodsmentioning

confidence: 99%

Clinical Efficacy of Intravenous Immunoglobulin for Patients with MPO-ANCA-Associated Rapidly Progressive Glomerulonephritis

Ito‐Ihara

Ono²,

Nogaki³

et al. 2005

Nephron Clin Pract

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Background: To determinewhether intravenous immunoglobulin (IVIg) cancontrol disease activity in patients with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated rapidly progressive glomerulonephritis (RPGN). Methods: Twelve patients with serologically and histologically confirmed MPO-ANCA-associated RPGN (7 men, 5 women; mean age 71 ± 3 years) received IVIg (400 mg/kg/day) alone for 5 days. The effects of IVIg were evaluated by white blood cell counts, serum C-reactive protein levels, Birmingham Vasculitis Activity Score, rate of change in reciprocal creatinine (1/Cre), and plasma tumor necrosis factor-α levels after IVIg administration. Corticosteroids with or without cyclophosphamide were commenced after IVIg. Results:After IVIg treatment, a significant decrease was observed in white blood cell count (p < 0.05), C-reactive protein values (p < 0.001), and Birmingham Vasculitis Activity Score (p < 0.001) concomitant with the amelioration of systemic symptoms. The rate of change in 1/Cre significantly improved (p < 0.05). Plasma tumor necrosis factor-α levels that were significantly elevated in patients before IVIg compared with normal controls (p < 0.0001), rapidly declined after IVIg with a significant reduction(p < 0.05). Three months post-treatment with IVIg, all patients showed improvement of disease without serious infectious complications. Conclusion: IVIg is a potential component of remission induction therapy for patients with MPO-ANCA-associated RPGN.

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“…The investigators hypothesized that substances in the environment might have bound to the cytoplasmic MPO leading to modified self-determinant inducing autoimmunity to MPO. Asbestos particles in the air increased more than 20 times for 30 months after this earthquake, raising speculation of a possible causal role (15). On the other hand, some investigators claimed that the activation of alveolar macrophage by asbestos is the inciting event of asbestosis immunopathogenesis due to the release of lysosomal enzymes, fibrogenic factors, lymphokines and chemotactic factors which could lead to over activity of the B cell system and relaxation of the T cell surveillance (4).…”

Section: Discussionmentioning

confidence: 99%

Asbestos and Probable Microscopic Polyangiitis

Philteos

Coverett

Chibbar

et al. 2004

Canadian Respiratory Journal

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GSR Philteos, K Coverett, R Chibbar, HA Ward, DW Cockcroft. Asbestosis and probable microscopic polyangiitis. Can Respir J 2004;11(5):359-362.Several inorganic dust lung diseases (pneumoconioses) are associated with autoimmune diseases. Although autoimmune serological abnormalities are common in asbestosis, clinical autoimmune/collagen vascular diseases are not commonly reported. A case of pulmonary asbestosis complicated by perinuclear-antineutrophil cytoplasmic antibody (myeloperoxidase) positive probable microscopic polyangiitis (glomerulonephritis, pericarditis, alveolitis, multineuritis multiplex) is described and the possible immunological mechanisms whereby asbestosis fibres might be relevant in induction of antineutrophil cytoplasmic antibodies are reviewed in the present report.Key Words: Primary care; Screening; Spirometry Amiantose et polyangéite microscopique probablePlusieurs pneumopathies (pneumoconioses) liées aux poussières inorganiques sont associées à des maladies auto-immunes. Même si les anomalies sérologiques auto-immunes sont fréquentes dans l'amiantose, la documentation fait rarement état de maladies auto-immunes ou de collagénose avec manifestations cardiovasculaires décelables cliniquement. Voici un cas d'amiantose pulmonaire, compliquée d'une polyangéite (glomérulonéphrite, péricardite, alvéolite, polynévrite) microscopique probable à anticorps cytoplasmiques antineutrophiles périnucléaires (myéloperoxydase). Il sera également question de mécanismes immunitaires possibles mis en cause dans le rôle des fibres d'amiante dans l'induction des anticorps cytoplasmiques antineutrophiles.

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Significantly high regional morbidity of MPO-ANCA–related angitis and/or nephritis with respiratory tract involvement after the 1995 great earthquake in Kobe (Japan)

Cited by 62 publications

References 18 publications

Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis

Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis

Clinical Efficacy of Intravenous Immunoglobulin for Patients with MPO-ANCA-Associated Rapidly Progressive Glomerulonephritis

Asbestos and Probable Microscopic Polyangiitis

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