GSR Philteos, K Coverett, R Chibbar, HA Ward, DW Cockcroft. Asbestosis and probable microscopic polyangiitis. Can Respir J 2004;11(5):359-362.Several inorganic dust lung diseases (pneumoconioses) are associated with autoimmune diseases. Although autoimmune serological abnormalities are common in asbestosis, clinical autoimmune/collagen vascular diseases are not commonly reported. A case of pulmonary asbestosis complicated by perinuclear-antineutrophil cytoplasmic antibody (myeloperoxidase) positive probable microscopic polyangiitis (glomerulonephritis, pericarditis, alveolitis, multineuritis multiplex) is described and the possible immunological mechanisms whereby asbestosis fibres might be relevant in induction of antineutrophil cytoplasmic antibodies are reviewed in the present report.Key Words: Primary care; Screening; Spirometry
Amiantose et polyangéite microscopique probablePlusieurs pneumopathies (pneumoconioses) liées aux poussières inorganiques sont associées à des maladies auto-immunes. Même si les anomalies sérologiques auto-immunes sont fréquentes dans l'amiantose, la documentation fait rarement état de maladies auto-immunes ou de collagénose avec manifestations cardiovasculaires décelables cliniquement. Voici un cas d'amiantose pulmonaire, compliquée d'une polyangéite (glomérulonéphrite, péricardite, alvéolite, polynévrite) microscopique probable à anticorps cytoplasmiques antineutrophiles périnucléaires (myéloperoxydase). Il sera également question de mécanismes immunitaires possibles mis en cause dans le rôle des fibres d'amiante dans l'induction des anticorps cytoplasmiques antineutrophiles.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.