Significantly high levels of estrogen and MDA together induce tumor progression in Oral squamous cell carcinoma

Nath, Anirudh; Anand, Vishal; Anshu, Aseem Kumar; Rashmi, Tuhin; Singh, Jarnail; Jain, Pushpendra Kumar; Sinha, Reena; Kumar, Shailendra

doi:10.9790/2402-081221825

Cited by 2 publications

(3 citation statements)

References 18 publications

(14 reference statements)

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“…Few studies reported an increase in plasma and serum MDA level when histological grades of the disease advance with statistical significance (p < 0.001) [40] and (p < 0.01) [34]. On the contrary, three studies stated that lipid peroxidation level was inversely proportional to the degree of differentiation of OSCC as the grade advances.…”

Section: Discussionmentioning

confidence: 96%

“…The included studies had found a statistically significant increase in plasma or serum MDA levels in OSCC patients compared with controls (p < 0.001) [8,12,[19][20][21][22]24,30,32,[35][36][37]39,40,43,46,47,49,65]. Similarly, other studies also observed a significant rise compared with the control group (p < 0.05) [8,17,25,31,34,44,52,53,67]. Other studies also reported MDA rise in erythrocytes with statistical significance (p < 0.001) [20,26], (p < 0.01) [38] and (p < 0.05) [5,17,27].…”

Section: Discussionmentioning

confidence: 98%

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Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis

Mohideen

Sudhakar

Thayumanavan

et al. 2021

CIMB

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Objective: To qualitative and quantitatively review published literature assessing the oxidative stress marker malondialdehyde (MDA) in oral squamous cell carcinoma (OSCC). Methodology: Pubmed (MeSH), Science Direct, Scopus, Web of Science, Willey Online Library, Cochrane, and Cross Reference were searched for studies assessing MDA levels in OSCC samples. Results: From the 1008 articles identified, 849 were excluded based on title and abstract screening due to duplication and irrelevance to the topic of interest. Full-text assessment of the remaining 159 articles led to the inclusion of only 46 articles that satisfied the selection criteria. Of these, only 26 studies had data compatible for quantitative analysis. The MDA levels in OSCC groups are significantly increased (p < 0.00001) in plasma, serum, and saliva samples in the majority of the studies evaluated. In contrast, MDA levels in OSCC tissue samples are significantly attenuated (p < 0.00001) compared to healthy controls, supported by fewer studies. Conclusions: The augmented MDA levels in plasma, serum, and saliva samples of the OSCC reflect the heightened oxidative stress level accurately. Further studies are required to understand the attenuated MDA levels in the tissue samples of OSCC. Correlation analysis between MDA levels with established clinicopathological prognostic markers could aid in formulating oxidative stress-based prognostication and treatment planning.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis

Mohideen

Sudhakar

Thayumanavan

et al. 2021

CIMB

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“…Hormone associated cancers like those of breast, ovary, testis, thyroid, prostrate pose a quite distinctive mechanism of carcinogenesis [5]. Literature search fetched up few researches and reviews linking the role of hormones and oral cancer [6][7][8][9]. Endogenous and exogenous hormones act by exciting cell proliferation thus increasing the risk of mutations in their normal target cells as well as stimulating the growth of the mutated cells thereby providing chance for random genetic errors [5,10].…”

Section: Introductionmentioning

confidence: 99%

Role of Hormones in Oral Squamous Cell Carcinoma - An Update

Jain

Gupta

et al. 2021

J. Anal. Oncol.

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Background: Hormones have been recognized as regulator of the cell growth, differentiation and maturation. It has become increasingly evident that hormone may play a crucial role in the genesis and progression of several cancers like those of breast, ovary, testis, thyroid, prostrate including oral cancer. Aim: Present overview aims to discuss and provide data on possible role of various hormones including stress hormone, sex hormone, parathyroid and related hormone protein, melatonin and active metabolite of vitamin D3 in causation and progression of Oral squamous cell carcinoma (OSCC). Data Acquisition: A systematic search of existing literature was carried out for the keywords like hormones and cancer, hormones and oral cancer or OSCC utilizing the Google, Google Scholar and PubMed databases for extraction, assortment and compilation of data. Inference: In conclusion, we found that hormones are directly or indirectly involved in the pathogenesis of the OSCC and can be utilized in its management and prevention.

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Significantly high levels of estrogen and MDA together induce tumor progression in Oral squamous cell carcinoma

Abstract: Abstracts: Oral squamous cell carcinoma (OSCC) is believed to possess one of the highest incidences every year in

Cited by 2 publications

References 18 publications

Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis

Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis

Role of Hormones in Oral Squamous Cell Carcinoma - An Update

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