Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis

Abstract

Objective: To qualitative and quantitatively review published literature assessing the oxidative stress marker malondialdehyde (MDA) in oral squamous cell carcinoma (OSCC). Methodology: Pubmed (MeSH), Science Direct, Scopus, Web of Science, Willey Online Library, Cochrane, and Cross Reference were searched for studies assessing MDA levels in OSCC samples. Results: From the 1008 articles identified, 849 were excluded based on title and abstract screening due to duplication and irrelevance to the topic of interest. Full-text assessment of the remaining 159 articles led to the inclusion of only 46 articles that satisfied the selection criteria. Of these, only 26 studies had data compatible for quantitative analysis. The MDA levels in OSCC groups are significantly increased (p < 0.00001) in plasma, serum, and saliva samples in the majority of the studies evaluated. In contrast, MDA levels in OSCC tissue samples are significantly attenuated (p < 0.00001) compared to healthy controls, supported by fewer studies. Conclusions: The augmented MDA levels in plasma, serum, and saliva samples of the OSCC reflect the heightened oxidative stress level accurately. Further studies are required to understand the attenuated MDA levels in the tissue samples of OSCC. Correlation analysis between MDA levels with established clinicopathological prognostic markers could aid in formulating oxidative stress-based prognostication and treatment planning.

Assessment of lipid peroxidation status in the serum of Moroccan patients with nasopharyngeal carcinoma

“…These results are in agreement with previously reported studies showing elevated MDA levels in the tissues and serum of NPC patients [10]. Similar results were reported in other cancers including oropharyngeal cancer [13], ocular carcinoma [14], breast cancer [15], and bladder cancer [16], highlighting the interest to consider MDA status as a potential biomarker of cancer development and progression. In fact, scientific evidence has shown that disrupted tissues undergo peroxidation more quickly than healthy ones [17].…”

Assessment of Oxidative Stress and Inflammatory Markers of Medical Importance in Oral Squamous Cell Carcinoma

“…Hence, serves as a potential biomarker of an oxidative stress or a disease condition (Mohideen et al, 2021). Another oxidative stress biomarker in OSCC is Isoprostane-F2α that is produced by the peroxidation of arachidonic acid, catalyzed by free radicals.…”

Salivary Redox Homeostasis in Human Health and Disease

“…A huge meta-analysis of MDA levels also points to oxidative damage in oral cancer. MDA in saliva and plasma is increased in oral squamous cell carcinoma, but in tissue samples, MDA is attenuated [ 75 ]. Thus, understanding the pro- and antioxidant balance is essential for future therapeutic and detection strategies in cancer treatment.…”

“…Their results showed a significant difference between salivary SOD levels of gingivitis patients and periodontitis patients. They observed higher levels of salivary SOD levels in patients with gingivitis than for patients with periodontitis [ 75 ]. Novakovic et al (2014) investigated the effect of non-surgical periodontal treatment on salivary antioxidants.…”