Significant Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus

Svoren, Britta M.; Volkening, Lisa K.; Wood, Jamie; Laffel, Lori

doi:10.1016/j.jpeds.2008.07.015

Cited by 169 publications

(173 citation statements)

References 19 publications

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“…Our research is in line with previous research conducted in RSSA Malang, 90% of children with T1DM had low levels of 25(OH)D 3 [14]. The same result also obtained in various countries, such as in the United States, Switzerland, and Australia, where in patients with T1DM suffered from vitamin D deficiency and insufficiency [11,12,13].…”

Section: Subject Characteristicssupporting

confidence: 92%

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Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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Type 1 Diabetes Mellitus (T1DM) has become a health problem in many countries. T1DM is the consequence of autoimmune destruction process of β cells. There was relationship between vitamin D deficiency with T1DM. The destruction process was caused by an imbalance of pro-inflammatory and anti-inflammatory cytokines. One of the pro-inflammatory cytokines is IL-2. C-peptide examination to see the function of beta cells due to destruction of pancreatic beta cell. Administration of vitamin D 3 supplementation still cause controversy and give varying results. This randomized clinical trial was conducted to determine the levels of 25(OH)D 3 , IL-2, and C-peptide in people with T1DM who received vitamin D 3 supplementation. The subjects were 26 children with T1DM, divided into K1 group (received vitamin D 3 supplementation) and K2 group (received placebo). The results showed higher levels of 25(OH)D 3 in the K1 group and statistically found a significant difference (p = 0.00). Higher levels of IL-2 and lower C-peptide were obtained in the K1 group and no statistically significant differences were found (p = 0.76 and p= 0.26). The insignificant relationship and the negative correlation were found between 25(OH)D 3 and IL-2 (p = 0.71; r = -0.12), 25(OH)D 3 and C-peptide (p = 0.59; r = -0.16), also levels of IL-2 and C-peptide (p = 0.13; r = -0.44) in children with type 1 diabetes who received vitamin D3 supplementation. From this study can be concluded that administration vitamin D 3 supplementation in patients with T1DM can increase levels 25(OH)D 3 significantly. This increase has not significantly lowered levels of IL-2 and increased levels of C-peptide. However, there was an absolute decrease in the rate of slower C-peptide in the supplemented group than in the placebo group.

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Section: Subject Characteristicssupporting

confidence: 92%

“…Research in various countries, such as in the United States, Switzerland, Australia, and Indonesia mentioned that people with T1DM suffered from vitamin D deficiency and insufficiency [11,12,13,14]. Administration vitamin D3 supplementation can prevent or reduce autoimmune damage and destruction of pancreatic β cells [7].…”

Section: Introductionmentioning

confidence: 99%

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Suryanto

Tjahjono

Widjajanto

2018

J.Trop.Life.Science

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“…Studies by Tahrani, Bucan and Svoren similarly showed deficiency in vitamin D in patients with diabetes (27)(28)(29). Vitamin D deficiency mechanism in children is different (30) and in patients with diabetes type 1 it includes genetic susceptibility factors, accompanying albuminuria or renal excretion of vitamin D and/or its metabolites (28,31).…”

Section: Discussionmentioning

confidence: 99%

Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

et al. 2017

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Background: Type 1 Diabetes mellitus (DM) causes changes in bone mineral density (BMD). Objectives: The aim of this study was to evaluate BMD in children with type 1 DM and predictive factors of BMD loss in these patients. Methods: This cross-sectional study was conducted on 112 children with type 1 DM referrtd to children's medical center in Tehran, Iran during 2015 and 2016. Serum levels of hemoglobin A1c (HbA1c), Insulin-like growth factor 1 (IGF-1), 25-hydroxy vitamin D (25(OH) D), calcium, phosphorus, parathyroid hormone (PTH), alkaline phosphates (ALP), Fasting blood sugar (FBS) was recorded. Lumbar

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“…Prevalence varied from as high as 90.60% with a vitamin D cutoff value of < 30 ng/ mL in Qatar (6), to as low as 15% with a vitamin D cutoff value of < 20 ng/mL at Joslin's diabetes center (9), and intermediate prevalence of 54% with a vitamin D cutoff value of < 32 ng/mL in DIASS study (8). In one north Indian study, 58% children with T1DM aged between 6 and 12 year were vitamin D-deficient as compared with only 32% in the control group (25).…”

Section: Discussionmentioning

confidence: 99%

“…In the past decade, interest in diabetes mellitus and vitamin D metabolism has grown. Many epidemiological studies have found high prevalence of VDD in children with type 1 diabetes mellitus (TIDM), suggesting an association between the two (7)(8)(9)(10). Type 1 DM is an autoimmune disease with contribution from environmental insults in its causation (11).…”

Section: Introductionmentioning

confidence: 99%

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

Daga

Laway

Shah

et al. 2012

Arq Bras Endocrinol Metab

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OBJECTIVES: Vitamin D deficiency is common at all ages, and low levels of vitamin D have been associated with high incidence of type 1 diabetes. Similar results are not consistent for type 2 diabetes. The aim of the present study was to estimate vitamin D status in newly detected youth-onset diabetes in north India. SUBJECTS AND METHODS: This was a prospective case control study at a tertiary care hospital in north India. Seventy two newly detected youth-onset diabetes subjects (age < 25 years), and 41 age- and gender-matched healthy controls were studied. In addition to basic information and management regarding their diabetes, metabolic parameters and serum 25(OH)D were measured in both the groups. RESULTS: Vitamin D deficiency was seen in 91.1% of the subjects with diabetes, and 58.5% of the healthy controls. Mean ±SD 25(OH)D was significantly low, 7.88 ± 1.20 ng/mL in subjects with diabetes against 16.64 ± 7.83 ng/mL in controls. Sixty percent of cases had severe Vitamin D deficiency compared with 8.3% in controls. Levels of vitamin D did not correlate with clinical parameters, such as gender, body mass index; or with biochemical parameters, such as serum calcium, phosphorus, alkaline phosphatase, fasting plasma glucose, and HbA1C. CONCLUSION: Vitamin D deficiency is common in people with youth-onset diabetes.

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Significant Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus

Cited by 169 publications

References 19 publications

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Levels of 25(OH)D3, IL-2, and C-peptide in Children with Type 1 Diabetes Mellitus (T1DM) Receiving Vitamin D3 Supplementation

Status of Bone Mineral Density in Children with Type 1 Diabetes Mellitus and Its Related Factors

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

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