Significant reduction in bilirubin levels in a patient with Gilbert's Syndrome under isotretinoin treatment for acne vulgaris: A new area of use for isotretinoin?

Kurtipek, Gülcan Saylam; Sarı, Nihal; Akyürek, Fatma Tunçez

doi:10.1111/dth.12884

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…The authors noted isotretinoin could be continued safely without serious hepatic adverse effects. Interestingly, a reduction in bilirubin levels during isotretinoin therapy was observed on subsequent follow‐up of the patient (Saylam Kurtipek, Sarı, & Tuncez, ). Kurtipek et al also reported that low‐dose (20 mg/day) isotretinoin therapy can potentially reduce total and indirect bilirubin levels in acne patients.…”

Section: Safety Of Low‐dose Isotretinoinmentioning

confidence: 88%

Low dose of isotretinoin: A comprehensive review

Abdelmaksoud

Lotti

Anadolu

et al. 2020

Dermatologic Therapy

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Isotretinoin is a first‐generation retinoid initially approved for the treatment of severe cases of acne vulgaris (nodulocystic acne). Because of its broad anti‐inflammatory and immunomodulatory properties, it has been used beyond its initial approval in a myriad of other indications. Adverse effects of isotretinoin vary from xerosis to teratogenicity. Herein, we reviewed the literature, through date‐unlimited PubMed search, from inception till December 2019, using the following search terms: “low‐dose isotretinoin” and “dermatology,” “isotretinoin and safety,” “isotretinoin, off‐label uses,” “isotretinoin and male fertility,” “isotretinoin, iPLEDGE system,” aiming to deliver a therapeutic update relevant to clinical practice. All English‐language articles were considered with no limitation based on the articles' type. Low‐dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in the field of gastroenterology. We also highlight on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotretinoin.

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Section: Safety Of Low‐dose Isotretinoinmentioning

confidence: 88%

Low dose of isotretinoin: A comprehensive review

Abdelmaksoud

Lotti

Anadolu

et al. 2020

Dermatologic Therapy

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“…In general, the liver carries out several thousand biochemical functions, all of which are performed by enzymes. Changes in the levels of these enzymes are used to evaluate liver function (Saylam Kurtipek, Sarı, & Tuncez, ). Measuring AST and ALT enzymes is one of the most useful tests for the diagnosis of acute hepatocellular diseases, such as hepatitis.…”

Section: Introductionmentioning

confidence: 99%

The effect of silymarin on liver enzymes in patients taking isotretinoin: A randomized clinical trial

Mirnezami

Jafarimanesh

Rezagholizamenjany

et al. 2020

Dermatologic Therapy

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The aim of the present study was to investigate the effect of silymarin (Livergol) on liver enzymes in patients taking isotretinoin (Roaccutane). In this double‐blind clinical trial, 74 patients with acne and taking isotretinoin were randomly assigned into intervention (N = 37) and control (N = 37) groups. The intervention group received a 140 mg Livergol capsule per day for 30 days. The control group received a starch‐containing capsule as a placebo once a day for 30 days. Liver enzyme levels were measured before and after the intervention. The data were analyzed using chi‐square test, Independent t test, paired sample t test and analysis of covariance (ANCOVA). The results showed no statistically significant difference between the intervention and control groups at the beginning of study in levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) (p > .05). At the end of the study, a statistically significant difference was observed between the two groups in levels of AST and ALT (p < .05). Livergol prevented liver enzymes from increasing, so it can be used as an effective, low‐cost, and low‐complication treatment for the problem of increased levels of liver enzymes following the use of isotretinoin.

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