Significant Increase of Prostaglandin E‐Major Urinary Metabolite in Male Smokers: A Screening Study of Age and Gender Differences Using a Simple Radioimmunoassay

Okayasu, Isao; Ohnishi, Haruo; Sárándi, I.; Shojima, Junko; Komatsu, Junko; Oritsu, Masae; Sasabe, Masataka; Nanami, Kaori Okayasu; Matsuura, M.; Azumi, Jun-ichi; Ito, Satoru; Fujiwara, Mutsunori

doi:10.1002/jcla.21640

Cited by 33 publications

(40 citation statements)

References 29 publications

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“…On the hand it is not clear whether determination of RBCs count and all its indices concentration can be useful in diagnostic monitoring of patients suffered from allergic rhinitis who are encountered with cigarette smoking, Our results also revealed that immunity of male patients in some parts have more affected by smoking than female. Similar findings have reported by Hakim IA, et al and Okayasu I, et al in which some biomarkers were significantly higher in males than in females 26,27 .…”

Section: Resultssupporting

confidence: 91%

The Effect of Smoke Cigarette on Immune Responses of Allergic Rhinitis Patients

Moulaei¹,

Tabatabaei²,

Khazaei³

et al. 2014

Biosci., Biotechnol. Res. Asia

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Allergic rhinitis (AR) is the most widely distributed diseases of upper respiratory tract. The disease is involved many immunological activities and any changes in this system can increase the risk of allergic rhinitis. The disease is also affected by some environmental agents such as dust house, mites, pollens, animal danders and cigarette smoking. The aim of this study was to investigate the effect of cigarette smoking on different immune system of patients suffered from allergic rhinitis divided in two groups as cigarette and non cigarette smokers to find whether these patients are more sensitive to cigarette smoke than others and this may aggravate allergies. This analytic descriptive study was conducted on 632 allergic rhinitis patients aged between 17 to 69 years olds referred to the hospitals of Zahedan city from 2005 to 2012. Complete blood cell count such as WBCs, RBCs, lymphocytes, Hb, the amount of serum IgA, IgG, IgM, C3, C4 levels and total serum IgE of patients were measured using a commercial SRID and nephelometry methods. The significant differences in obtained results were evaluated by ÷2statistical test and SPSS software. The results indicated that low number of neutrophils, and low amount of IgA and IgM were found in smokers compared with nonsmokers. Increased number of WBCs, RBCs, lymphocytes and increased level of Hb, serum IgG, IgE, C3, C4, were found in smokers compared with nonsmokers. Significant correlation between all indices of smokers and nonsmokers individuals were observed (P value 0.01). Study results indicated that cigarette smoking is a risk factor for the development of allergic rhinitis and changing in variety immune responses, have a role in pathogenicity of disease.

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Section: Resultssupporting

confidence: 91%

The Effect of Smoke Cigarette on Immune Responses of Allergic Rhinitis Patients

Moulaei¹,

Tabatabaei²,

Khazaei³

et al. 2014

Biosci., Biotechnol. Res. Asia

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“…21 Researchers have also used high performance liquid chromatography, radio immunoassay and enzyme immunoassay for measuring markers of cigarette toxicity in body fluids. [22][23][24][25] Non-invasive techniques (such as Pulse Oximetry based on absorbance at particular wavelengths) are also commonly used for measuring carboxyhaemoglobin and carbon monoxide concentration apart from classical measurement of these analytes in blood by spectrophotometric techniques. 26,27 Metabolites use in detecting smoking status…”

Section: Quantitative Techniques Used For Measuring Cigarette Toxicitymentioning

confidence: 99%

Current research on cigarette toxicity: critical appraisal in view of clinical laboratory

Gyawali

Oguoma

2016

Int J Res Med Sci

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“…Okayasu et al [15] reported that PGE-MUM levels in normal healthy subjects (n = 797) showed sex-and agerelated differences. PGE-MUM levels in men were higher than those in women.…”

Section: Fluctuation Of Pge-mum Levels In Healthy Subjectsmentioning

confidence: 99%

“…The characteristics of this kit have been reported [6,15] . This treatment gives rise to a more stable compound for measurement.…”

Section: Pge-mum Assaymentioning

confidence: 99%

“…In blood, PGE2 is immediately metabolized by 15-hydroxy prostaglandin dehydrogenase (15-PGDH), which is present in the lung and colon, into 15-keto-PGE2. Next, in the liver and kidney, 15-keto-PGE2 is converted into 13,14-dihydro-15-keto PGE2 by the action of Δ13-reductase, followed by β-oxidation and ω-oxidation; this is finally converted to PGE-MUM (7α-hydroxy-5,11-diketotetranor-prosta-1,16-dioic acid) and excreted along with urine [15] .…”

Section: Uc Pathogenesis and The Synthesis And Metabolism Of Pge2mentioning

confidence: 99%

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Prostaglandin E-Major Urinary Metabolite as a Biomarker for Inflammation in Ulcerative Colitis: Prostaglandins Revisited

Arai¹,

Matsuura

et al. 2016

Digestion

Self Cite

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With the development of new therapeutic approaches, the ultimate goal of ulcerative colitis (UC) treatment is not only clinical remission but also mucosal healing. Successful mucosal healing has been associated with a dramatic risk reduction in UC recurrence and colitis-associated cancer development, which are the most critical complications of UC. However, invasive tests such as colonoscopy and biopsy are required to evaluate mucosal healing. Therefore, frequent examinations are unsuitable for UC patients. Mucosal inflammation of the colon and prostaglandin E2 production are assumed to be correlated; therefore, we considered that prostaglandin E-major urinary metabolite (PGE-MUM; 7-hydroxy-5,11-diketotetranor-prosta-1,16-dioic acid) may be a surrogate biomarker of UC activity. In this review, we propose that PGE-MUM levels reflect the colonoscopic and histological appearance of UC, suggesting that it is a more sensitive biomarker than those previously utilized for UC-related mucosal inflammation. According to the ‘organ-specific chronic inflammation-carcinoma sequence' theory, by measuring PGE-MUM periodically, it would be possible to control inflammation, with subsequent prevention of UC recurrence and colitis-associated cancer development. The measurement of urine samples for PGE-MUM - a simple, noninvasive method - can reduce the patient burden as well as medical costs, suggesting its potential for application in routine practice.

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Significant Increase of Prostaglandin E‐Major Urinary Metabolite in Male Smokers: A Screening Study of Age and Gender Differences Using a Simple Radioimmunoassay

Abstract: PGE-MUM increases in smokers, as suggested by possible inflammatory injury of pulmonary tissue. This RIA method for PGE-MUM may be thus a sensitive and reliable biomarker for current inflammation, different from serum CRP.

Cited by 33 publications

References 29 publications

The Effect of Smoke Cigarette on Immune Responses of Allergic Rhinitis Patients

The Effect of Smoke Cigarette on Immune Responses of Allergic Rhinitis Patients

Current research on cigarette toxicity: critical appraisal in view of clinical laboratory

Prostaglandin E-Major Urinary Metabolite as a Biomarker for Inflammation in Ulcerative Colitis: Prostaglandins Revisited

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