Prostaglandin E-Major Urinary Metabolite as a Biomarker for Inflammation in Ulcerative Colitis: Prostaglandins Revisited

Arai, Yoshinori; Matsuura, Tomokazu; Matsuura, M.; Fujiwara, Mutsunori; Okayasu, Isao; Ito, Satoru; Arihiro, Seiji

doi:10.1159/000441665

Cited by 30 publications

(25 citation statements)

References 37 publications

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“…Prostaglandin plays a pivotal role in allergic inflammation. Moreover, reducing the level of prostaglandin exerts a protective effect against IBD and may represent a future safe treatment for IBD [44][45][46]. Furthermore, treatment with natural products could attenuate colitis by downregulating the level of prostaglandin.…”

Section: Discussionmentioning

confidence: 99%

Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach

Huang

Chen

et al. 2020

BMC Complement Med Ther

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Background Inflammatory bowel disease (IBD) is a severe digestive system condition, characterized by chronic and relapsing inflammation of the gastrointestinal tract. Scutellaria baicalensis Georgi (Huangqin, HQ) and Paeonia lactiflora Pall (Baishao, BS) from a typical herbal synergic pair in traditional Chinese medicine (TCM) for IBD treatments. However, the mechanisms of action for the synergy are still unclear. Therefore, this paper aimed to predict the anti-IBD targets and the main active ingredients of the HQ-BS herbal pair. Methods A systems pharmacology approach was used to identify the bioactive compounds and to delineate the molecular targets and potential pathways of HQ-BS herbal pair. Then, the characteristics of the candidates were analyzed according to their oral bioavailability and drug-likeness indices. Finally, gene enrichment analysis with DAVID Bioinformatics Resources was performed to identify the potential pathways associated with the candidate targets. Results The results showed that, a total of 38 active compounds were obtained from HQ-BS herbal pair, and 54 targets associated with IBD were identified. Gene Ontology and pathway enrichment analysis yielded the top 20 significant results with 54 targets. Furthermore, the integrated IBD pathway revealed that the HQ-BS herbal pair probably acted in patients with IBD through multiple mechanisms of regulation of the nitric oxide biosynthetic process and anti-inflammatory effects. In addition, cell experiments were carried out to verify that the HQ-BS herbal pair and their Q-markers could attenuate the levels of nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated THP-1-derived macrophage inflammation. In particular, the crude materials exerted a much better anti-inflammatory effect than their Q-markers, which might be due to their synergistic effect. Conclusion This study provides novel insight into the molecular pathways involved in the mechanisms of the HQ-BS herbal pair acting on IBD.

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Section: Discussionmentioning

confidence: 99%

Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach

Huang

Chen

et al. 2020

BMC Complement Med Ther

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“…Research has shown that the occurrence of chronic ulcerative colitis is accompanied by the formation of immune complexes and cytokines, which is difficult to treat[ 47 ]. Of these cytokines, IL-8 can lead to chemotaxis of neutrophils, eosinophils, lymphocytes and other cells, and the release of media that can damage endothelial cells and related tissues and organs, leading to inflammation[ 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, abdominal pain was not significantly relieved after treatment in the control group, while abdominal pain was relieved in the experimental group. This suggests that neutrophil chemotactic factors are released through the activation of macrophages in patients with chronic ulcerative colitis, and both macrophages and neutrophils can increase IL-8 secretion, leading to inflammation[ 47 ]. After stellate ganglion block treatment, the inflammatory chemokine IL-8 was reduced in patients in the experimental group, chemotaxis was inhibited, and peripheral blood histamine only slightly increased; thus, reducing inflammation[ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of stellate ganglion block in chronic ulcerative colitis

Zhao¹,

Yang²,

Sun³

et al. 2017

WJG

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AIMTo investigate the efficacy and safety of stellate ganglion block for the treatment of patients with chronic ulcerative colitis.METHODSA total of 120 randomly selected patients with chronic ulcerative colitis treated in Cangzhou Central Hospital from January 2014 to January 2016 were included in this study. These patients were divided into two groups: control group (n = 30), patients received oral sulfasalazine treatment; experimental group (n = 90), patients received stellate ganglion block treatment. Clinical symptoms and disease activity in these two groups were compared before and after treatment using endoscopy. Blood was collected from patients on day 0, 10, 20 and 30 after treatment. Enzyme-linked immunosorbent assay was performed to determine interleukin-8 (IL-8) level. The changes in IL-8 level post-treatment in the two groups were compared using repeated measures analysis of variance.RESULTSAfter treatment, clinical symptoms and disease activity were shown to be alleviated by endoscopy in both the control and experimental groups. However, patients in the control group did not have obvious abdominal pain relief. In addition, the degree of pain relief in the experimental group was statistically better than that in the control group (P < 0.05). Ten days after treatment, IL-8 level was found to be significantly lower in the experimental group than in the control group, and the difference was statistically significant (P < 0.05). In addition, adverse events were significantly higher in the control group than in the experimental group, and the difference was statistically significant (χ2 = 33.215, P = 0.000).CONCLUSIONThe application of stellate ganglion block effectively improves treatment efficacy in chronic ulcerative colitis, relieves clinical symptoms in patients, and reduces the level of inflammatory factors. Furthermore, this approach also had a positive impact on the disease to a certain extent.

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“…[ 10 ] High concentrations of PGE2 in inflammatory sites prevents the absorption of electrolytes including sodium and chloride, which stimulates bowel motility. [ 11 ] Previous reports demonstrated PGE-MUM levels reflected disease activity in patients with UC [ 6 ] and CFIP. [ 12 ] Additionally, impaired uptake of PGE led to high concentrations of PGE-MUM in patients with CEAS.…”

Section: Discussionmentioning

confidence: 99%

“…[ 5 ] A previous report showed that PGE-MUM was elevated in patients with active ulcerative colitis (UC) and that the cutoff value for histological UC activity and remission was 17.0 μg/g Cre. [ 6 ] In patients with chronic fibrosing interstitial pneumonia (CFIP), PGE-MUM levels were also significantly higher than in controls. [ 7 ] These results suggest that PGE-MUM is a promising biomarker that might reflect disease activity.…”

Section: Introductionmentioning

confidence: 99%

Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients

Mizuno¹,

Wakui²,

Machida³

et al. 2017

Medicine

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Rationale:Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), which was reported to reflect the disease activity of ulcerative colitis and chronic fibrosing interstitial pneumonia. We recently experienced a case with elevated PGE-MUM at the time of diagnosis of MP and we investigated the potential of PGE-MUM as a biomarker.Patient concern:In this report we described 2 active mesenteric panniculitis patients with high PGE-MUM levels.Diagnoses:Mesenteric panniculitisInterventions:Both MP patients were measured the levels of PGE-MUM.Outcomes:Both MP patients exhibited high levels of PGE-MUM before treatment. In one, the levels were sensitively correlated with clinical symptoms and serological markers on steroids.Lessons:The study observations suggest the potential of PGE-MUM to reflect the disease activity of MP. To verify its use, more findings based on clinical studies should be accumulated.

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Prostaglandin E-Major Urinary Metabolite as a Biomarker for Inflammation in Ulcerative Colitis: Prostaglandins Revisited

Cited by 30 publications

References 37 publications

Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach

Herbal pair Huangqin-Baishao: mechanisms underlying inflammatory bowel disease by combined system pharmacology and cell experiment approach

Efficacy and safety of stellate ganglion block in chronic ulcerative colitis

Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients

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