Significant improvement in mild acne following a twice daily application for 6 weeks of an acidic cleansing product (pH 4)

Abels, Christoph; Reich, Hubert; Knie, Ulrich; Werdier, D.; Lemmnitz, Gunter

doi:10.1111/jocd.12086

Cited by 9 publications

(11 citation statements)

References 23 publications

(41 reference statements)

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“…An emollient with a pH of 4.8 altered skin barrier and microbes in infants at risk for developing atopic dermatitis . Skin care products adjusted to pH 4 have been used successfully in acne skin . These products improve the physiological microbial flora, skin barrier and lipid lamellae structure, reduce skin dryness and have been described to be more favorable compared with formulations with a pH of 5.8–6.0 .…”

Section: Reducing Skin Ph As a Therapeutic Tool In Wound Healing Skimentioning

confidence: 99%

“…105 Skin care products adjusted to pH 4 have been used successfully in acne skin. 106 These products improve the physiological microbial flora, skin barrier and lipid lamellae structure, reduce skin dryness and have been described to be more favorable compared with formulations with a pH of 5.8-6.0. 97,[107][108][109][110] Newborn and aged skin exhibit an increased SC pH, too.…”

Section: Reducing Skin Ph As a Therapeutic Tool In Wound Healing Skimentioning

confidence: 99%

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pH in nature, humans and skin

Proksch

2018

The Journal of Dermatology

377

273

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The pH plays an important physiological role in nature and humans. pH varies from 1 to 8 in human organs with tight regulation in blood and epithelia of barrier organs. The physiological pH of the stratum corneum is 4.1-5.8 and several mechanisms contribute to its formation: filaggrin degradation, fatty acid content, sodium-hydrogen exchanger (NHE1) activation and melanosome release. First, the acidic pH of the stratum corneum was considered to present an antimicrobial barrier preventing colonization (e.g. by Staphylococcus aureus and Malassezia). Later on, it was found that the pH influences skin barrier function, lipid synthesis and aggregation, epidermal differentiation and desquamation. Enzymes of ceramide metabolism (e.g. β-glucocerebrosidase or acid sphingomyelinase) as well as proteases (e.g. chymotryptic enzyme or cathepsin D linked to epidermal differentiation and desquamation) are regulated by the pH. Experimental disruption of the physical barrier leads to an increase of pH, returning to normal levels only after many hours. Inflammatory skin diseases and diseases with an involvement of the epidermis exhibit a disturbed skin barrier and an increased pH. This is known for atopic dermatitis, irritant contact dermatitis, ichthyosis, rosacea and acne, but also for aged and dry skin. Normalizing the pH by acidification through topical treatment helps to establish a physiological microbiota, to repair skin barrier, to induce epidermal differentiation and to reduce inflammation.

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Section: Reducing Skin Ph As a Therapeutic Tool In Wound Healing Skimentioning

confidence: 99%

Section: Reducing Skin Ph As a Therapeutic Tool In Wound Healing Skimentioning

confidence: 99%

pH in nature, humans and skin

Proksch

2018

The Journal of Dermatology

377

273

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“…We previously reported that a face gel wash and a micellar solution containing mandelic acid reduced acne symptoms [13]. In addition, Abels et al reported that twicedaily application of a topical glycolic acid-containing cleansing product (pH 4) for 6 weeks led to a significant improvement of mild acne [14]. However, the patients in our previous study were treated with wash-out cosmetics in addition to cream containing azelaic acid and sodium salicylate.…”

Section: Discussionmentioning

confidence: 61%

Evaluation of the efficacy and tolerability of mandelic acid-containing cosmetic formulations for acne skin care

Dębowska¹,

Kaszuba²,

Michalak³

et al. 2015

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Introduction. Acne vulgaris is a common, chronic skin disease that shows a characteristic clinical picture. Skin lesions occur primarily in the seborrheic areas of the body, i.e., the face, back, and chest. Mandelic acid yields very good results when used to treat excessive actinic keratosis (keratosis actinica), hyperpigmentation (lentigo solaris and melasma), and meshlike wrinkles, which are primarily caused by sun-induced aging of the skin. This therapy is well suited for the care of skin with acne vulgaris. Objective. To evaluate the efficacy of dermo-cosmetics containing 5% or 10% mandelic acid for the skin care of patients with acne vulgaris. Material and methods. An open study was carried out on 60 patients with papulo-pustular acne, who applied dermocosmetics to their skin for 2 months. Patients were divided into two subgroups of 30 patients each.One group was tested with a 5% mandelic acid containing cosmetic while the other group was tested with a 10% mandelic acid containing cosmetic. After the treatment was completed, acne severity was evaluated according to the Hellgren-Vincent scale. Results. Physical examinations performed during the study revealed a gradual improvement in the condition of the skin in both groups, with a reduction in the number of pustules, inflammatory nodules, and comedones. The proportion of patients in each group showing a reduction in disease severity according to the Hellgren-Vincent scale was similar. Conclusions. The results of the present study show that products containing 5% or 10% mandelic acid are both safe and effective for the treatment of acne. STRESZCZENIEWprowadzenie. Trądzik pospolity (acne vulgaris) jest częstą chorobą skóry o charakterystycznym klinicznie, przewlekłym przebiegu. Do-

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“…Ali and Yosipovitch emphasize that the creation of acidic skin pH is essential for management of inflammatory dermatoses, while clinicians should focus on the selection of topical agents compatible with the skin . Prior work has documented the effectiveness of acidifying emollients in lowering pH of skin surface . However, all of the investigated formulations contained AHAs, while only few studies focused on their safety, or they used subjective methods of skin safety investigations which are normally considered unreliable .…”

Section: Discussionmentioning

confidence: 99%

“…More recent studies show that SC acidification could be an effective strategy, even in management of the atopic march . Fortunately, SC acidification could normally be achieved by application of low pH topical formulations …”

Section: Introductionmentioning

confidence: 99%

A 10% Lactobionic acid‐containing moisturizer reduces skin surface pH without irritation—An in vivo/in vitro study

Tasić‐Kostov

Lukić

Savić

2019

J of Cosmetic Dermatology

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Summary Background/Objectives Stratum corneum acidification is a newer strategy in management of inflammatory dermatoses; acidifying emollients are normally used for that purpose. However, a decrease in pH of the skin is commonly connected to an increase in irritation. The aim of this study was to investigate whether lactobionic acid (LA), cosmeceutical active and "superacid" belonging to the class of alpha‐hydroxy acids (AHAs), could decrease pH of skin surface without irritation. Methods Safety profile of emulsion based on alkyl polyglucosides (APGs) sugar emulsifiers with 10% LA was evaluated in vitro (acute skin irritation test using cytotoxicity assay), and in vivo in safety study employing measurements of the relevant biophysical human skin parameters upon cessation of 24 hours occlusive treatment: transepidermal water loss (TEWL), stratum corneum hydration (SCH), and skin erythema index (EI). The effect on the pH of human skin surface was investigated by pH measurements prior and 1 hour after application of the emulsion with 10% LA. Results The pH of the skin was significantly reduced after application of LA‐containing emulsion. The results for in vitro skin irritation potential assessment were in line with the in vivo safety study, indicating a satisfactory safety profile of both APG‐based emulsion vehicle per se and emulsion with 10% LA. Conclusion Lactobionic acid (10%) in emulsion based on APGs reduces skin surface pH without irritation and skin barrier impairment; it could be proposed as an alternative to low‐molecular AHAs in acidifying emollients.

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Significant improvement in mild acne following a twice daily application for 6 weeks of an acidic cleansing product (pH 4)

Abstract: In this clinical trial, a topical cleansing product containing glycolic acid with pH 4 improved mild acne significantly following twice-daily application for 6 weeks as monotherapy.

Cited by 9 publications

References 23 publications

pH in nature, humans and skin

pH in nature, humans and skin

Evaluation of the efficacy and tolerability of mandelic acid-containing cosmetic formulations for acne skin care

A 10% Lactobionic acid‐containing moisturizer reduces skin surface pH without irritation—An in vivo/in vitro study

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