Significance of the Changes in the Circulating Lymphoid Cells in Hodgkin's Disease

Crowther, Derek; Fairley, G. Hamilton; Sewell, R. L.

doi:10.1136/bmj.2.5655.473

Cited by 71 publications

(17 citation statements)

References 8 publications

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“…Since we could exclude the possibility that normal T cells were affected by products of HD B cells, such as anti-T antibodies, it is reasonable to suppose that the reduction of spontaneous IgG production in vitro reflects differences in the regulatory ability of normal and HD T lymphocytes. This possibility was further supported by the observation that the addition of T (39), which spontaneously synthesize DNA (40,41) and show similarities with lymphocytes detectable under conditions of known antigenic challenge (42,43). It is also consistent with the demonstration of in vivo production of migration-inhibitory lymphokinelike substances (44 …”

Section: Resultssupporting

confidence: 69%

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Romagnani¹,

Prete²,

Maggi³

et al. 1983

J. Clin. Invest.

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A B S T R A C T The immunoglobulin-synthesizing activities of peripheral blood mononuclear cells from 57 untreated patients with Hodgkin's disease and 47 normal subjects were compared. Cumulative amounts of IgM and IgG synthesized and secreted by unstimulated and pokeweed mitogen-stimulated cells over a 7-d period were determined in a solid-phase radioimmunoassay. Synthesis of IgM in unstimulated cultures and of both IgM and IgG in cultures stimulated with pokeweed mitogen was markedly reduced in patients with Hodgkin's disease, whereas the mean level of the spontaneous IgG synthesis was enhanced. The degree and frequency of in vitro abnormalities were not influenced by disease stage or histology.Depression of pokeweed mitogen-induced immunoglobulin synthesis did not correlate with excessive number of monocytes and it was unaffected by removal of phagocytic cells or addition to the cultures of monocytes from normal individuals. On the other hand, monocytes isolated from blood of patients with Hodgkin's disease were even more effective than normal monocytes in supporting pokeweed mitogen-induced immunoglobulin synthesis by normal phagocyte-depleted mononuclear cells. Synthesis of both IgM and IgG induced by pokeweed mitogen remained subnormal after addition to patient B cell cultures of autologous irradiated T cells or allogeneic normal T lymphocytes. T cells from patients with Hodgkin's disease appeared at least as effective as normal T cells in helping pokeweed mitogen-induced immunoglobulin production by normal B cells. However, when normal T cells were co-cultured with B cells from patients with Hodgkin's disease, spontaneous IgG synthesis declined, whereas the addition of patient T cells

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Section: Resultssupporting

confidence: 69%

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Romagnani¹,

Prete²,

Maggi³

et al. 1983

J. Clin. Invest.

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“…It may be that nonspecific immunotherapeutic measures such as BCG (Mathe et al, 1969) (Crowther et al, 1969b). More recently, Swan and Knowelden (1971) have shown that the prognosis in Hodgkin's disease does appear to be correlated with the patient's peripheral blood lymphocyte count.…”

Section: Discussionmentioning

confidence: 99%

The Significance of Lymphocytic Infiltration in Neuroblastoma

Lauder¹,

Aherne²

1972

Br J Cancer

103

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Summary.-A study of the significance of lymphocytic infiltration was made in a retrospective series of 23 primary neuroblastomata. The degree of lymphocytic infiltration was estimated and scored in 5 categories. Non-parametric rank order statistical methods were used to establish quantitative correlations, particularly with the duration of survival. A significant positive correlation was found both in infancy and childhood. It was found, unexpectedly, that the presence of metastases did not invalidate the correlation between lymphocyte score and survival.

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“…Although the direct relationship shown in this report between spontaneous and PHA-induced DNA synthesis in Hodgkin's disease favors the former concept, the presence of "large lymphoid cells" engaged in DNA synthesis found in Hodgkin's blood (34) and the recent discovery of Hodgkin's disease tumor-associated antigens (35) provide a strong basis for the latter. It is conceivable that these two phenomena are related, and patients with pattern III may be at the end of a spectrum of patients with gradually increasing functional lymphocyte abnormality.…”

Section: Discussionmentioning

confidence: 69%

Quantitation of immunocompetence in Hodgkin's disease.

Faguet¹

1975

J. Clin. Invest.

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Significance of the Changes in the Circulating Lymphoid Cells in Hodgkin's Disease

Cited by 71 publications

References 8 publications

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

The Significance of Lymphocytic Infiltration in Neuroblastoma

Quantitation of immunocompetence in Hodgkin's disease.

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