The Significance of Lymphocytic Infiltration in Neuroblastoma

Lauder, I.; Aherne, W.

doi:10.1038/bjc.1972.43

Cited by 103 publications

(41 citation statements)

References 27 publications

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“…Similarly, antigens associated with transformation to the malignant state may be expressed (Laurence and Neville, 1972) and choriocarcinoma is neither more nor less likely than other tumours to have such antigens. It is interesting that similar cellular infiltrates to those seen in choriocarcinoma have also been described in other tumours, for example, in carcinoma of the stomach (Black, Opler and Speer, 1954), carcinoma of the breast (Berg, 1962;Black, Opler and Speer, 1956;Hamlin, 1968), malignant melanoma (Cochran, 1969) and neuroblastoma (Lauder and Aherne, 1972). Thirdly, since choriocarcinoma is a malignant allograft (Dowling, 1957;Hirsch, 1962) it may also exhibit individual-specific or transplantation antigens, inherited from the male parent of the antecedent conception.…”

Section: Discussionmentioning

confidence: 71%

Cellular Reaction in Trophoblastic Tumours

Elston¹,

Bagshawe²

1973

Br J Cancer

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Summary.-The presence of a mononuclear cell reaction to 41 gestational choriocarcinomata, 10 invasive moles and 13 malignant trophoblastic teratomata has been investigated. The intensity of the reaction was graded; there was a significantly better response to therapy and survival rate in those with a " severe " cellular reaction than in those with a " mild " reaction to gestational choriocarcinoma. The pathological and clinical features of invasive moles showed no relationship with the cellular reaction to the tumour. The cellular reaction to trophoblastic teratomata was generally poor but there was a marked cellular reaction to the tumour of one patient who has enjoyed a sustained remission.The relationship of cellular reaction and response to treatment with other histological and clinical features was examined. With the exception of a positive correlation between the degree of vascular invasion and response to treatment, none was found.It is suggested that an infiltrate of mononuclear cells in gestational choriocarcinoma is probably a response to the presence of tumour antigens. The infiltrate favourably affects the response to chemotherapeutic agents, suggesting that it contributes to tumour cell death and it may be interpreted as an immunological response directed at tumour rejection.

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Section: Discussionmentioning

confidence: 71%

Cellular Reaction in Trophoblastic Tumours

Elston¹,

Bagshawe²

1973

Br J Cancer

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“…The presence in some tumours of large numbers of lymphocytes has alreadv been mentioned and has been demonstrated by several groups of workers (Black et al, 1956;Berg, 1959;Lauder and Aherne, 1972). In the gastrointestinal tract lymphocyte infiltration may also reflect nonspecific factors such as ulceration and infection.…”

Section: Disc1ussionmentioning

confidence: 88%

“…Several studies have demonstrated that in a varietv of malignant neoplasms lvmphocytic infiltration of the tumour is associated with longer survival (Black, Opler and Speer, 1.956;Berg. 1959;Lauder and Aherne. 1972).…”

Section: Disc1ussionmentioning

confidence: 99%

Cellular Immunity, Peripheral Blood Lymphocyte Count and Pathological Staging of Tumours in the Gastrointestinal Tract

Bone¹,

Lauder²

1974

Br J Cancer

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Summary.-The peripheral blood lymphocyte count has been measured in 74 cases of histologically proven carcinoma of the gastrointestinal tract. The count has been correlated with the pathological stage of tumour spread and the patient's delayed hypersensitivity response to 2.4 dinitrochlorobenzene (DNCB). A statistically significant correlation was found between the peripheral blood lymphocyte count and the response to DNCB. There was linear association between the extent of spread of the tumours and the lymphocyte count. Those patients with low peripheral blood lymphocyte counts tended to have more advanced tumours and a poor response to DNCB. The possible causes of this lymphopenia are discussed.

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“…gastric cancer (Black et al 1954(Black et al , 1956(Black et al , 1971Cutler et al 1969), choriocarcinoma (Elston 1969), cutaneous malignant melanoma (Thompson 1972), neuroblastoma (Lauder and Aherne 1972), cervix carcinoma (Hamazaki 1968), esophageal carcinoma (Takahashi 1961) and pharyngeal carcinoma (Bennett et al 1971). Therefore, lymphocytic reaction in or around the tumor has been of great interest for patho logists.…”

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confidence: 99%