Cellular Reaction in Trophoblastic Tumours

Elston, C. W.; Bagshawe, K. D.

doi:10.1038/bjc.1973.144

Cited by 38 publications

(14 citation statements)

References 38 publications

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“…This has been reported in breast cancer (4), choriocarcinoma (5), neuroblastoma (6), and melanoma (7), among others. Also, macrophage phagocytosis of melanoma cells has been reported (8).…”

Section: Introductionmentioning

confidence: 55%

Mononuclear cell content of human solid tumors

Hersh

Mavligit

Gutterman

et al. 1976

Med. Pediatr. Oncol.

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The mononuclear cell content and mononuclear cell function of human solid tumors were determined. Twenty-eight primary, and 17 metastatic solid tumors, including 6 lymph node metastases, were obtained from 45 patients. Cells were released from the tumors by mincing, scraping, and sieving. Analysis of the cellular content was determined by light microscopy, and tumor lymphocyte function was determined by stimulation of blastogenesis with PHA, PWM, Con-A, MLC, and SLO. A median of 3.3 X 10(7) tumor cells with 12.5% viability was obtained per gram of tumor, and a median of 7.8 X 10(6) lymphocytes with a viability of 96% and 0.35 X 10(6) macrophages with a viability of 85% was also obtained per gram of tumor. Significant lymphocyte responses to various mitogens and antigens were obtained in 31-40% of the tumor lymphocyte preparations. From 9.4% to 23% had vigorous responses with a stimulation index greater than 10. Primary tumors contained significantly more lymphocytes than metastatic tumors; thus, the percent lymphocytes in primary tumors was 13.5% compared to 5% for metastatic tumors. In contrast, some of the lymphocyte responses were significantly greater for metastatic tumors than primary tumors. These data suggest that the direct study of lymphocytes infiltrating primary and metastatic tumors may be a useful approach to understanding tumor immunity in man.

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“…This has been reported in breast cancer (4), choriocarcinoma (5), neuroblastoma (6), and melanoma (7), among others. Also, macrophage phagocytosis of melanoma cells has been reported (8).…”

Section: Introductionmentioning

confidence: 55%

Mononuclear cell content of human solid tumors

Hersh

Mavligit

Gutterman

et al. 1976

Med. Pediatr. Oncol.

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“…It has been suggested that the infiltration of mononuclear cells in gestational choriocarcinoma is a response to tumour antigens (Elston and Bagshawe, 1973). Such a reaction could also reflect the histocompatibility differences between tumour and host, since the evidence presented in this paper favours the idea that trophoblastic tumours express HLA specificities.…”

Section: Cellular Reactionmentioning

confidence: 63%

Immunogenetics of trophoblastic tumours

Lawler¹

1976

Journal of Clinical Pathology

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“…Elston and Bagshawe [9] reported that an infiltrate of mononuclear cells in trophoblastic tumors was probably a response to the presence of tumor antigens. In this study, however, the amount of TIL recovered was greater in patients without recurrence than in those with recurrence within 2 years after complete resection.…”

Section: Discussionmentioning

confidence: 99%

Role of tumor‐infiltrating lymphocytes in the host defense mechanism against lung cancer

Yasumoto

Takeo

Yano

et al. 1988

Journal of Surgical Oncology

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Tumor-infiltrating lymphocytes (TIL) and tumor-associated macrophages (TAM) were recovered from 22 patients with primary lung cancer. The TIL did not exhibit any cytolytic activity against various target cells. The average percentage of TIL recovered was 6.7 +/- 1.3% in patients without recurrence, as compared to 3.6 +/- 0.6% in those with recurrence within 2 years after complete resection of lung cancer (P less than 0.05). The average cytostatic activity of TAM was 38.5 +/- 6.8% in patients without recurrence, although it was 25.2 +/- 4.6% in those with recurrence within 2 years after complete resection (P less than 0.1). The activity of macrophage activating factor (MAF) induced by TIL was also higher in patients showing no recurrence. A significant positive correlation was observed between MAF activity induced by TIL and the cytostatic activity of individual TAM. These results suggest that antitumor activity of TAM may be controlled by specifically sensitized TIL through lymphokines.

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Cellular Reaction in Trophoblastic Tumours

Cited by 38 publications

References 38 publications

Mononuclear cell content of human solid tumors

Mononuclear cell content of human solid tumors

Immunogenetics of trophoblastic tumours

Role of tumor‐infiltrating lymphocytes in the host defense mechanism against lung cancer

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